The Prevalence of Intestinal Parasites Is Not Greater Among Individuals With Irritable Bowel Syndrome: A Population-based Case-control Study

Krogsgaard, Laura Rindom; Engsbro, Anne Line; Stensvold, Christen Rune; Nielsen, Henrik Vedel; Bytzer, Peter

doi:10.1016/j.cgh.2014.07.065

Cited by 124 publications

(106 citation statements)

References 27 publications

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“…Although this is a relatively small sample-set and the study particpants comprised both related and unrelated individuals (and therefore are not a randomly sampled population), our data indicates that the prevalence rate of Blastocystis in the US region of Boulder, Colorado, is much lower than that the ~25%-55% carriage rates reported from other industrialised countries such as those in Europe (Bart et al, 2013;Krogsgaard et al, 2015;Scanlan et al, 2014).…”

Section: Discussioncontrasting

confidence: 40%

“…However, there is considerable variation in prevalence rates between different populations; for example, recent reports have given positive prevalence rates of anywhere between ~24-100% for different populations living in Europe, the Middle East, India and Africa (AbuOdeh et al, 2016;Alfellani et al, 2013;Bart et al, 2013;El Safadi et al, 2014;Krogsgaard et al, 2015;Pandey et al, 2015;Scanlan and Stensvold, 2013;Scanlan et al, 2014). With respect to Blastocystis transmission to humans, three distinct modes of transmission have been proposed (Tan, …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Scanlan

Knight

Song

et al. 2016

Infection, Genetics and Evolution

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Section: Discussioncontrasting

confidence: 40%

Section: Introductionmentioning

confidence: 99%

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Scanlan

Knight

Song

et al. 2016

Infection, Genetics and Evolution

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“…Our results are in contrast with a study from the west of Iran (23) and other studies from Turkey, India, France, and Mexico which showed a higher prevalence of Blastocystis infection in IBS population compared to the control group (2,6,24,25), but similar to those reported studies from Thailand and Denmark (26,27). A notable feature of the current study is that the control group was selected from healthy people without GI symptoms, which it can be extended to the whole community in Ahvaz.…”

Section: Discussioncontrasting

confidence: 57%

“…In recent years, many researches have been performed to elucidate the possible role of Blastocystis in health or disease. In many studies it was linked to bowel diseases (27,(37)(38)(39), but recent studies show that this organism might have an important role in human health and could be considered as a gastrointestinal health marker (5).…”

Section: Discussionmentioning

confidence: 99%

Comparative Prevalence of Blastocystis in Patients with the Irritable Bowel Syndrome and Healthy Individuals: A Case Control Study

Beiromvand

Hashemi

Arjmand

et al. 2017

Jundishapur J Microbiol

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Background: Blastocystis is one of the most common anaerobic protozoa found in the intestinal tract of humans and various animals, with a worldwide distribution. The parasite has been linked to the pathogenesis of the irritable bowel syndrome (IBS), previously. Objectives: The aim of this study was to evaluate the prevalence of Blastocystis in IBS patients compared to healthy individuals. Methods: The collected feces from 152 patients with Gastrointestinal (GI) symptoms, and 130 healthy volunteers from Ahvaz, southwest Iran, were examined using the direct saline smear, Lugol's iodine staining, and inoculated in a Jones' medium for Blastocystis detection. The DNA was extracted from all culture-positive samples, and then the polymerase chain reaction (PCR) was performed by the SSU-rDNA gene. Results: Blastocystis was identified in 18 (6.4%) samples, including two (1.3%) of the IBS patients and 16 (12.3%) of the control group by microscopy. Stool culture was positive in 15 with IBS, one without IBS, and 40 control samples. From these, the expected 600 bp fragments of the SSU-rDNA gene were identified in 15 (27.3%) cases and 40 (72.7%) controls. Subtypes (STs) 1, 2, and 3 were identified from the 54 successfully sequenced samples. Subtype 3 was the most common ST with the frequency of 46.3%, followed by ST2, 37% and ST1, 16.7% in the case and control groups. The highest frequency of Blastocystis STs (27.8%) was identified in the age group of 31-40 years and the lowest was found in the age groups of under 10 years and over 81 years. Conclusions:The findings of the current study showed that Blastocystis was more common in the control group compared to the IBS patients. Therefore, our findings highlight the contrast between Blastocystis infection and GI disorders. Furthermore, these results support the hypothesis that Blastocystis could be a GI health marker.

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“…30 Detection of Blastocystis by PCR has been associated with higher microbiota diversity and lower abundance of Enterobacteriaceae, and has inconsistently been associated with irritable bowel syndrome (IBS). [31][32][33] However, the literature on this topic is inconsistent.…”

Section: Limitations Of Screening Asymptomatic Donorsmentioning

confidence: 99%

Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review

et al. 2017

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Fecal microbiota transplantation is best understood as an effective and inexpensive therapy for recurrent Clostridium difficile infection but fecal donor selection and screening should be periodically revised. Here, we review current recommendations for selection and screening of fecal donors for fecal microbiota transplantation. We recommend considering diabetes mellitus, prior cardiovascular events, and clinical healthcare exposure as fecal donor exclusion criteria until more is known about the association of these conditions with the human gut microbiome. We review the non-bacterial members of the human gut microbiome, associations of the gut microbiome with colorectal malignancies, the human gut resistome and how these may impact future donor screening recommendations. Collaboration between clinicians, clinical laboratory scientists, industry and regulatory agencies will be critically important for continued improvement in donor selection and screening.

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The Prevalence of Intestinal Parasites Is Not Greater Among Individuals With Irritable Bowel Syndrome: A Population-based Case-control Study

Cited by 124 publications

References 27 publications

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Comparative Prevalence of Blastocystis in Patients with the Irritable Bowel Syndrome and Healthy Individuals: A Case Control Study

Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review

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