The Prevalence of Ischemic Heart Disease in Hypertensive Patients Presenting Aortic Valve Sclerosis: PP.2.58

Abstract

telomere length than aortic segments. On the other hand, telomere length was shorter in aortic tissues which presented atherosclerotic lesions compared to corresponding tissues without atherosclerotic lesions. There was a negative correlation between pulse pressure and telomere length only in atherosclerotic tissues. In conclusion, the present data suggest an in situ regulation of telomere length in different arterial tissues with or without atheroma. These results also suggest tissue regulation of telomere size by local factors likely related to oxidative stress responses.Objective: Hypertension is associated with increased oxidative stress, which may have an impact on further cardiovascular risk. There are only a few and controversial data on the effect of beta-blockers on oxidative stress. The aim of the present study was to evaluate the effects of nebivolol (NEB) and metoprolol (MET) succinate on oxidative stress in hypertension. Design and Method:In a double-blind study 80 mild to moderate essential hypertension patients (mean age 47 AE 10 years; 41 male, 39 female) were randomized to receive either MET succinate 50-100 mg or NEB 5 mg once daily for 1 year. Peripheral blood pressure (BP), plasma oxidized low-density lipoprotein (oxLDL), total cholesterol, LDL-cholesterol, HDL-cholesterol, glucose, urine excretion of 8-iso PGF-2a adjusted to urine creatinine were measured at baseline and after 1 year of treatment.