The prevalence of leucocyte alloantibodies in blood donors from South China

Xia, Wenjie; Ye, X.; Xu, Xiuzhang; Chen, D.; Deng, Jing; Chen, Y.; Ding, Haoqiang; Shao, Yuan; Wang, J.; Liu, J.; Li, H.; Huang, Yi‐Zhi; Fu, Yongshui

doi:10.1111/tme.12276

Cited by 10 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16,17 So far, this could be demonstrated only in small cohorts of a few hundred donors. [17][18][19][20] HNA antibody testing is a major hurdle, as there is currently no high-throughput screening technology available.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Granulocyte antibodies in male blood donors: can they trigger transfusion‐related acute lung injury?

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…Consequently, HNA and HLA Class I and II antibodies have been detected also in male donors . So far, this could be demonstrated only in small cohorts of a few hundred donors …”

mentioning

confidence: 99%

Granulocyte antibodies in male blood donors: can they trigger transfusion‐related acute lung injury?

et al. 2018

View full text Add to dashboard Cite

show abstract

“…HNA- 1b1c ( FCGR3B*03 ) or HNA-1b1d ( FCGR3B*02 ). Recently the FCGR3B*01 316G>A and the FCGR3B*02 244A>G variants were found and named FCGR3B*04 and FCGR3B*05 , respectively (table 1) [7,22,23,24,25,26]. Variation in expression of the HNA-1 alleles is possible.…”

Section: Pathologymentioning

confidence: 99%

“…One remarkable difference compared with the Caucasian population is the complete absence of the HNA-1c allele. Only a very limited number of studies have been performed on the allele frequencies in the African population [20,21,22]. …”

Section: Pathologymentioning

confidence: 99%

Neonatal Alloimmune Neutropenia

Porcelijn

Haas

2018

Transfus Med Hemother

View full text Add to dashboard Cite

Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and fetal/neonatal alloimmune thrombocytopenia (FNAIT). A limited number of prospective screening studies showed that granulocyte-specific antibodies were detectable in 0.35-1.1% of random postnatal maternal samples and that the incidence of NAIN was below 0.1%. Symptoms vary from none to mild skin infections, omphalitis or more severe infections like pneumonia, sepsis, and meningitis. Treatment of neonatal infection with antibiotics and granulocyte-colony stimulating factor is advised.

show abstract

“…Существует ограниченное количество проспективных скрининговых исследований по выявлению анти-HNA аллоантител [5,6]. Сведения о частоте аллоантител к HNA у доноров крови и её компонентов в Российской Федерации отсутствуют.…”

unclassified

Frequency and specificity of alloantibodies to HNA system antigens in donors of blood and blood components

et al. 2020

View full text Add to dashboard Cite

Aim. To study the rate of human neutrophil antigens (HNA) alloimmunization in donors of blood and blood components. Methods. The study included blood samples of 1,127 donors who donated blood and its components in the Russian Scientific and Research Institute of Hematology and Transfusiology, Saint Petersburg, 635 male and 492 female. 36.18% of female donors were aged between 18 and 30 (n=178) and 63.82% were aged between 30 and 60 (n=314). The medical histories of all donors did not contain the records about the transfusion of blood components. Screening and identification of HNA alloantibodies were performed using the flow cytometric granulocyte immunofluorescence test with monoclonal antibodies CD16-PE, CD45-PC7, CD19-APC, Goat F(ab')2 Anti-Human IgG-FITC and the panel of donor neutrophils with detected HNA genotypes. Results. The frequency of HNA alloantibodies in blood donors was 0.35% (n=4). No HNA alloantibodies were found in the male donors. Alloantibodies were detected only in female blood donors aged between 30 and 60. HNA antibody frequency in female donors was 0.81%. It were detected anti-HNA-1a, anti-HNA-3b and anti-HNA-4b antibodies of the IgG immunoglobulin class. In one donor, the specificity of antibodies could not be established. To establish whether detected antibodies in immunized donors were alloantibodies, HNA genotypes were determined. Сonclusion. HNA alloantibodies occur with low frequency and are determined in 0.35% of blood donors. Alloantibodies were detected only in female donors and were directed against HNA-1a, HNA-3b and HNA-4b. The frequency of HNA antibodies in female donors was 0.81%. HNA genotyping confirmed that detected antibodies were alloantibodies.

show abstract

The prevalence of leucocyte alloantibodies in blood donors from South China

Cited by 10 publications

References 21 publications

Granulocyte antibodies in male blood donors: can they trigger transfusion‐related acute lung injury?

Granulocyte antibodies in male blood donors: can they trigger transfusion‐related acute lung injury?

Neonatal Alloimmune Neutropenia

Frequency and specificity of alloantibodies to HNA system antigens in donors of blood and blood components

Contact Info

Product

Resources

About