The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese

Jia, Jianping; Zhou, Aihong; Wei, Cuibai; Jia, X.; Wang, Fen; Li, Fang; Wu, Xiaoguang; Mok, Vincent; Gauthier, Serge; Tang, Miaoling; Chu, Lan; Zhou, You-long; Zhou, Chunkui; Cui, Yong; Wang, Qi; Wang, Weishan; Yin, Peng; Hu, Nan; Zuo, Xianbo; Song, Haiqing; Qin, Wei; Wu, Liyong; Li, Dan; Jia, Longfei; Song, Juexian; Han, Ying; Xing, Yi; Yang, Peijie; Li, Yuemei; Qiao, Yuchen; Tang, Yi; Lv, Jihui; Dong, Xingtong

doi:10.1016/j.jalz.2013.09.008

Cited by 163 publications

(133 citation statements)

References 43 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…However, most studies on this subject were cross-sectional, and the incidence of MCI has never been estimated before in Asian countries [22,23]. To our knowledge, this is the first study from an Asian country to report the incidence of MCI in an elderly population.…”

Section: Discussionmentioning

confidence: 99%

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Bae

Kim

Han

et al. 2014

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD. © 2014 S. Karger AG, Basel

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Bae

Kim

Han

et al. 2014

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…One strength of our study is that prevalences were compared between rural and urban communities in a city using an exhaustive survey with a sufficiently high participation rate. Many previous epidemiologic studies compared prevalences between rural and urban populations of different geographical regions [8,18,19], which may have reflected regional differences rather than rural-urban differences. The present study was designed to overcome this methodological limitation.…”

Section: Discussionmentioning

confidence: 99%

Rural–urban differences in the prevalence of cognitive impairment in independent community-dwelling elderly residents of Ojiya city, Niigata Prefecture, Japan

Nakamura

Kitamura

Watanabe

et al. 2016

Environ Health Prev Med

View full text Add to dashboard Cite

show abstract

“…It affects the individual's ability to function independently. With the aging of Chinese population, dementia and mild cognitive impairment (MCI) become a significant public health problem, the prevalence is increasing, now representing 5.14% for dementia and 20.8% for MCI, indicating that approximately 5.9 million and 23.9 million Chinese aged 65 years and older with dementia and MCI are currently living in China respectively (1,2). This underlines the importance of risk factors assessment and early intervention of cognitive function in China.…”

Section: Introductionmentioning

confidence: 99%

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Yin

Chei

et al. 2016

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Objectives-The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly.Design-A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models. Conflict of interestThe authors declare that there are no conflicts of interests. Ethical standardsThe authors declare that all the experiments of this study complied with the current laws of China in which they were performed. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptSetting-Community-based setting in eight longevity areas in China.Subjects-A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study. Measurements-Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score≤23.Results-There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62-0.84) for TC, 0.81(0.70-0.94) for LDL-C and 0.81(0.70-0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years).Conclusions-These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.

show abstract

The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese

Abstract: The prevalence of MCI in elderly Chinese is higher in rural than in urban areas. Vascular-related MCI (MCI-CVD and MCI-VRF) was most common.

Cited by 163 publications

References 43 publications

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Rural–urban differences in the prevalence of cognitive impairment in independent community-dwelling elderly residents of Ojiya city, Niigata Prefecture, Japan

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Contact Info

Product

Resources

About