The prevalence of neutropenia and association with infections in patients with systemic lupus erythematosus: a Swedish single-center study conducted over 14 years

Saleh, Muna; Sjöwall, Johanna; Bendtsen, Marcus; Sjöwall, Christopher

doi:10.1007/s00296-024-05566-9

Cited by 3 publications

References 56 publications

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Emergencies in inflammatory rheumatic diseases

Auyezkhankyzy,

Izekenova,

Kocyigit

2024

Rheumatol Int

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Inflammatory rheumatic diseases (IRDs), encompassing a broad spectrum of chronic disorders, typically necessitate prolonged therapeutic intervention. Nevertheless, these diseases can sometimes manifest as severe emergencies requiring prompt and extensive medical intervention. Urgent intervention is essential for effectively recognizing and managing these situations, as they have the potential to be life-threatening and can result in severe morbidity and mortality. Emergencies in IRDs can occur with different frequencies and manifestations, including nervous system issues, severe infections, thrombosis-emboli, renal crises, gastrointestinal issues, and cardiovascular events. The fact that these events can occur across different IRDs underscores the necessity for heightened awareness and readiness among healthcare professionals. The pathophysiologic mechanisms that cause rheumatic emergencies are complex and involve multiple factors. These emergencies frequently arise due to the interplay between the inflammatory characteristics of rheumatic diseases and different systemic triggers. Early detection and treatment can have a substantial impact on an individual’s prognosis in cases of severe and life-threatening disorders that require prompt recognition. Rapid decision-making and urgent care are required to effectively address rheumatic emergencies, as well as the implementation of a diagnostic flowchart. This article provides an overview of the emergencies linked to IRDs, classifying and assessing them individually. This article aims to enhance healthcare professionals’ knowledge and awareness of critical situations by examining current recommendations and pathophysiological information. Implementing standardized diagnostic and treatment methods, providing patient education, and conducting continuing research into the underlying mechanisms are essential for enhancing the management of these critical situations and improving patient outcomes.

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Emergencies in inflammatory rheumatic diseases

Auyezkhankyzy,

Izekenova,

Kocyigit

2024

Rheumatol Int

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“The Association of the IL-1RA (rs315952) Cytokine Gene Polymorphism and Susceptibility to Systemic Lupus Erythematosus: A Meta-analysis”

Carlos,

Gabriel,

Gatbunton

2024

Preprint

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Through a general retrospective analysis of the IL-1RAmspa11,100 (rs315952) cytokine gene polymorphism's genotypes and alleles, the T/T genotype, along with the individual T allele, shows significant associations with the risk of Systemic Lupus Erythematosus (SLE). Meanwhile, the C/C and C/T genotypes, as well as the individual C allele, exhibited no significant associations. These results imply that having a homozygous genotype for the T allele increases the likelihood of SLE occurrence, while having a single C allele may induce a protective effect against the disease. To obtain these results, the researchers employed the analysis of six selected case-control and cross-sectional studies on healthy individuals SLE patients diagnosed through PCR tests. Forest plot construction was done to assess potential overlapping confidence intervals among the qualified studies. To identify the degree of heterogeneity among the papers, the odds ratio and the total confidence intervals, with the confidence interval set at 95%, were acquired through fixed and random effects models. Genotype and allele analyses with I2 statistics higher than 40% led to the funnel plot construction for outlier detection. Currently, the underlying processes that led to these genes' and alleles' varying outcomes to SLE risk remain elusive. Meanwhile, the subjects' IL-1RA haplotypes may undermine these findings, along with the need for environmental consideration and the potential alteration of the gene and its corresponding alleles due to epigenetics. However, these findings still remain a possible starting point or reference for future studies.

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Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults

Chen,

Cao,

Guo

et al. 2024

J Int Med Res

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Objective To explore the relationship between leukocyte count and renal function in patients with lupus nephritis (LN). Methods We performed a retrospective cross-sectional study of 100 patients with LN admitted to the Department of Nephrology between 1 January 2015 and 30 December 2023. Based on tertile of leukocyte count, they were allocated to Low, Medium, or High groups. The demographic, clinical, and pathologic characteristics of the groups were compared and the relationship between leukocyte count and renal function was analyzed using multiple linear regression analysis. Results After adjustment for age, albumin, 24-hour proteinuria, serum complement factor 3, hemoglobin, blood pressure, systemic lupus erythematosus disease activity index score, and histologic parameters, a linear relationship was identified between leukocyte count and renal function (regression coefficient −2.852; 95% confidence interval: −5.161, −0.543). Therefore, for every 1 × 109/L increase in leukocyte count, the estimated glomerular filtration rate would decrease by 2.85 mL/minute. Conclusion There is an independent linear relationship between leukocyte count and renal function. Leukocyte recruitment into the kidney is a critical step in the progression of LN, and as the leukocyte count increases, renal function gradually declines. Leukocyte count may represent a sensitive biomarker of the progression and prognosis of LN.

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The prevalence of neutropenia and association with infections in patients with systemic lupus erythematosus: a Swedish single-center study conducted over 14 years

Cited by 3 publications

References 56 publications

Emergencies in inflammatory rheumatic diseases

Emergencies in inflammatory rheumatic diseases

“The Association of the IL-1RA (rs315952) Cytokine Gene Polymorphism and Susceptibility to Systemic Lupus Erythematosus: A Meta-analysis”

Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults

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