The prevalence of “novel” food allergens worldwide: a systematic review

Moonesinghe, Harriet; Kilburn, Sally; MacKenzie, Heather; Venter, Carina; Lee, Kellyn; Dean, Tara

doi:10.1186/2045-7022-5-s3-p9

Cited by 2 publications

(2 citation statements)

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“…MCA disorders (largely as allergic-type diseases and more complex presentations now termed "MCAS") are prevalent, judging merely by the known 10-50% global prevalence of allergy (e.g. [37][38][39][40][41][42][43]). This figure unsurprisingly is congruent with not only some of the higher estimates of prevalence for MCAS [11,44,45] but also (given that chronic multisystem inflammation is, more than any other clinical feature, the sine qua non of MCAS) estimates for prevalence of the spectrum of chronic inflammatory diseases [43,46,47].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of mast cell activation syndrome: a global “consensus-2”

Ackerley²,

et al. 2020

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The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of “mast cell activation syndrome” (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a “consensus” (re-termed here as “consensus-1”). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as “consensus-2”), resembling “consensus-1” in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by “consensus-2” criteria has potential to be problematic, but underdiagnosis by “consensus-1” criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of mast cell activation syndrome: a global “consensus-2”

Ackerley²,

et al. 2020

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“…Sesame and mustard seeds are among the 14 most prevalent allergens in the EU, but not in the US [61]. In Europe, prevalence data indicates sesame and mustard seed allergies are geographically disproportionate: high in some areas (France and Spain), much lower in others (Germany and the Nordic countries) and unknown in Eastern Europe [62]. Mustard and sesame seeds are often hidden in commercial foods, making scrutiny of labels required at all times.…”

Section: Avoidance Diet: Towards Personalized Nutrition Advicementioning

confidence: 99%

Personalized Nutrition Approach in Food Allergy: Is It Prime Time Yet?

et al. 2019

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The prevalence of food allergy appears to be steadily increasing in infants and young children. One of the major challenges of modern clinical nutrition is the implementation of individualized nutritional recommendations. The management of food allergy (FA) has seen major changes in recent years. While strict allergen avoidance is still the key treatment principle, it is increasingly clear that the avoidance diet should be tailored according to the patient FA phenotype. Furthermore, new insights into the gut microbiome and immune system explain the rising interest in tolerance induction and immunomodulation by microbiota-targeted dietary intervention. This review article focuses on the nutritional management of IgE mediated food allergy, mainly focusing on different aspects of the avoidance diet. A personalized approach to managing the food allergic individual is becoming more feasible as we are learning more about diagnostic modalities and allergic phenotypes. However, some unmet needs should be addressed to fully attain this goal.

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The prevalence of “novel” food allergens worldwide: a systematic review

Cited by 2 publications

References 0 publications

Diagnosis of mast cell activation syndrome: a global “consensus-2”

Diagnosis of mast cell activation syndrome: a global “consensus-2”

Personalized Nutrition Approach in Food Allergy: Is It Prime Time Yet?

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