The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

Tong, H. Tammy; Isenring, Elisabeth; Yates, Patsy

doi:10.1007/s00520-008-0472-7

Cited by 149 publications

(131 citation statements)

References 23 publications

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“…Especially fatigue, oral dryness and pain at rest seemed to affect EI negatively. The findings were consistent with our hypothesis and are in accordance with studies suggesting that patients with weight loss experience symptoms that may affect their EI [29,26]. To our knowledge, this is the first direct comparison between actual EI intake and symptom intensity in patients with PC.…”

Section: Discussionsupporting

confidence: 92%

“…The QLQ-PAN26 includes 26 items covering symptoms related to PC and its treatment (pancreatic pain, dietary changes, altered bowel habits, indigestion, flatulence, oral dryness, taste changes, cachexia and jaundice) as well as emotional problems (body image, fear of future health, healthcare satisfaction and sexuality) [23]. For this study we only used the eight items/scales covering symptoms most likely to influence dietary intake; pancreatic pain, dietary changes, altered bowel habits, indigestion, flatulence, oral dryness, taste changes and cachexia [25,26]. All items have the following four-answer categories, "not at all," "a little," "quite a bit," or "very much" that were converted to 0-100 scales according to the EORTC methodology [27].…”

Section: Symptom Assessmentmentioning

confidence: 99%

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Symptoms in advanced pancreatic cancer are of importance for energy intake

Bye

Jordhøy

Skjegstad

et al. 2012

Support Care Cancer

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Purpose: Cancer cachexia and low energy intake (EI) probably contribute to weight loss in advanced pancreatic cancer (PC). However, little is known about the actual EI in this disease. Aims were to assess EI, weight loss and symptoms during the disease course and investigate associations between symptoms and EI.Methods: Thirty-nine patients (21 males) with advanced PC were consecutively included and followed every 4 weeks until the end of life. A 24-hour dietary recall was used to assess EI. The Edmonton Symptom Assessment System (ESAS) and the PC-specific health-related quality of life questionnaire (QLQ-PAN26) were used for symptom assessment. Conclusion:In this study several symptoms influenced EI negatively. Low EI did not completely explain weight loss in this patient group, but careful monitoring and early follow-up of symptoms may be important interventions to reduce weight loss in advanced PC.

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Section: Discussionsupporting

confidence: 92%

Section: Symptom Assessmentmentioning

confidence: 99%

Symptoms in advanced pancreatic cancer are of importance for energy intake

Bye

Jordhøy

Skjegstad

et al. 2012

Support Care Cancer

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“…The radiation reaction is also prone to cause damage of the salivary glands, reduce salivation, saliva become viscous, and the patient can have chewing and swallowing difficulties. Radiation damage may improve over months and some may never return to the level prior to treatment (24). During the course of treatment, patients also appear nausea and vomiting, anorexic, with full bilge, diarrhea, catarrh, stomatitis, pain and other symptoms (25).…”

Section: Discussionmentioning

confidence: 99%

Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial

Kang

Huang

et al. 2016

Molecular and Clinical Oncology

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Abstract. Head and neck malignant tumors have numerous locations of the disease. After patients receive radiotherapy, their nutritional status is very poor, thus the curative effect is unsatisfactory. The aims of the present study were to investigate and analyze the nutritional status of patients with head and neck cancer undergoing radiotherapy (RT) in order to provide positive nutrition intervention for assisting the radiotherapy effect. A total of 40 patients with head and neck cancer were selected using a method of subjective global assessment (SGA) to assess nutritional status, including calorie intake and energy expenditure. In a randomized, controlled study, 20 patients received intensive dietary counseling and nutritional therapy (G1) and 20 received regular dietary as controls (G0) preradiotherapy and postradiotherapy. The primary endpoint was calorie intake and energy expenditure. The secondary endpoint was SGA rating with nutritional therapy. At the end of RT, energy intake showed a net increase in G1 (1,691±301 kcal) compared with that in G0 (1,066±312 kcal) (P<0.05); energy expenditure increased in G1 (1,673±279 kcal) compared with G0 (1,490±298 kcal) (P<0.05). The prevalence of severe malnutrition following radiotherapy was significantly different between the two study groups (10 patients in G0 and 4 patients in G1; P<0.05). The number of the normal malnutrition patients postRT in G0 decreased from 4 to 2 and conversely, in G1 it increased from 3 to 6 (P<0.05). In conclusion, patients with head and neck cancer were most malnutritioned, which impacted on clinical outcome. Timely nutritional intervention can effectively prevent weight loss and muscle wasting.Additionally, it may improve quality of life by decreasing the frequency of severe malnutrition.

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“…1 Some studies have reported that nutritional risk tends to worsen during the course of admission and has been associated with increased morbidity and mortality, prolonged hospital stay and increased health-care costs in the patients with cancer. 1,2 The value of nutritional support for patients with cancer is to improve the clinical outcomes. 3 Our multicenter prospective cohort study has showed that of the patients at nutritional risk, the complication rate was significantly lower in the nutritional-support group than in the no-support group, and multivariate analysis showed nutritional support was a protective factor for complications in at-risk patients when adjusted for confounders.…”

Section: Introductionmentioning

confidence: 99%

A multicentre study to implement nutritional risk screening and evaluate clinical outcome and quality of life in patients with cancer

Kang

Zhou

2013

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: To implement nutritional risk screening and evaluate the relationship of nutritional risk to complication rate and quality of life in patients with cancer. SUBJECTS/METHODS: A total of 687 patients with cancer from two teaching hospitals in China were consecutively enrolled. Data were collected on the nutritional risk screening, application of nutritional support, complication and quality of life. RESULTS: The prevalence of nutritional risk at admission among the total, younger and elderly patients was 45.6%, 38.7% and 58.0%, respectively. There was a significant increase in the prevalence from admission to 2 weeks after admission in all patients (P ¼ 0.011). The prevalence in those patients X70 years was significantly higher than that in the younger ones (Po0.001). The highest prevalence of nutritional risk was in pancreas cancer (81.8%). Only 46.7% of at-risk patients received nutritional support and the average PN:EN ratio was 7.0:1. Complications were noted in 29.0% of all patients and were significantly more frequent in 'at-risk' patients (Po0.001). Among the scales of quality of life (SF-36), the scores of physical functioning (Po0.001), role-physical (Po0.001), bodily pain (P ¼ 0.012), energy/fatigue (Po0.001) and general health (Po0.001) were significant lower in the patients at risk. CONCLUSIONS: A large proportion of cancer inpatients were at nutritional risk and tended to worsen during the course of admission, which has been associated with increased complication rate and lower scores of quality of life. The application of PN and EN was inappropriate in patients with cancer in China.

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The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

Cited by 149 publications

References 23 publications

Symptoms in advanced pancreatic cancer are of importance for energy intake

Symptoms in advanced pancreatic cancer are of importance for energy intake

Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial

A multicentre study to implement nutritional risk screening and evaluate clinical outcome and quality of life in patients with cancer

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