The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis

Azadvari, Mohaddeseh; Mirmosayyeb, Omid; Hosseini, Maryam; Vaheb, Saeed; Razavi, Seyede Zahra Emami

doi:10.1007/s10072-022-05871-w

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…A retrospective cohort study in 1,232 patients with MS and 12,320 matched controls showed more common primary hip fragility fractures in the MS cohort compared with the matched cohort ( 41 ). A recent systematic review and meta-analysis of 35 studies identified the pooled prevalence of osteoporosis to be 17% in 13,906 patients with MS ( 42 ). Another comprehensive systematic review and meta-analysis of 86 studies in the world including 103,334,579 people suggested the prevalence of osteoporosis to be 18.3% ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

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Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

Gao

et al. 2022

Front. Neurol.

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Multiple sclerosis (MS) is a neurodegenerative disorder and an autoimmune disease. Until now, observational studies have indicated the association of bone mineral density (BMD) and fracture with the risk of MS. However, these studies indicated inconsistent findings. Until now, genome-wide association studies (GWAS) have been conducted in BMD, fracture, and MS, which provide large-scale datasets to investigate the causal association of BMD and fracture with the risk of MS using the Mendelian randomization (MR) study. Here, we performed an MR study to clarify the causal association between BMD/fracture and the risk of MS using large-scale publicly available GWAS datasets from BMD, fracture, and MS. We first evaluated the bidirectional causal effects of BMD and MS. The main analysis method inverse-variance weighted (IVW) showed no significant causal effect of BMD on the risk of MS (β = 0.058, and p = 1.98E-01), and MS on the risk of BMD (β = −0.001, and p = 7.83E-01). We then evaluated the bidirectional causal effects of fracture and MS. However, we only identified a significant causal effect of fracture on the risk of MS using IVW (β = −0.375, p = 0.002), but no significant causal effect of MS on the risk of the fracture using IVW (β = 0.011, p = 2.39E-01). Therefore, our main analysis method IVW only found a significant causal effect of fracture on MS using the threshold for the statistically significant association p < 0.05/4 = 0.0125. Meanwhile, multivariable MR analyses showed that the causal effect of fracture on MS was independent of smoking, drinking, and obesity, but dependent on BMD. In summary, our MR analysis demonstrates that genetically increased fracture may reduce the risk of MS. Our findings should be further verified and the underlying mechanisms should be further evaluated by future studies.

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Section: Discussionmentioning

confidence: 99%

“…of osteoporosis to be 17% in 13,906 patients with MS (42). Another comprehensive systematic review and meta-analysis of 86 studies in the world including 103,334,579 people suggested the prevalence of osteoporosis to be 18.3% (43).…”

Section: Figurementioning

confidence: 99%

Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

Gao

et al. 2022

Front. Neurol.

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“…In our study, EG increased the seconds spent in the wall squat position (p ≤0.01). In addition, improving lower limb function results in beter postural control and a safer and faster gait: the TUG is a widely validated test in elderly populations or those with nerve impairments because it gives us important information on static and dynamic balance control during walking ability often impaired in individuals with neurodegenerative diseases30,31 and in our study, unlike the control group, the exercise group finished the test after the 8 weeks in fewer seconds (p ≤0.01) thus improving performance.Osteoporosis is common in MS patients because this progressive bone disease is enhanced by the decreasing of bone mechanical loading and the prolonged disability32 . Therefore, we decided to investigate if HIIT was able to affect bone remodeling and metabolism markers.…”

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confidence: 99%

High-Intensity Interval Training improves bone remodeling, lipid profile, and physical function in multiple sclerosis patients

Amato,

Proia,

Alioto

et al. 2024

Preprint

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Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease due to an autoimmune chronic inflammatory response and the etiology is currently not completely understood. Is already known that physical activity plays an essential role in improving quality of life, especially in neuropathological conditions. The study aimed to investigate the possible benefits of high-intensity interval training (HIIT) in bone and lipid metabolism markers, and neuromotor abilities in MS patients. 130 participants were recruited; 16 subjects with MS met the inclusion criteria and were included in the data analysis. The patients were randomly assigned to two groups: a control group (CG) (34,88 ± 4,45 yrs) that didn’t perform any physical activity and the Exercise group (EG) (36,20 ± 7,80 yrs) that performed HIIT protocol. The training program was conducted remotely by clinical kinesiology. It was performed three times a week for 8 weeks. At the beginning (T0) and the end of the study (T1) were performed Bioimpedance analysis, coordination skills tests, and bone and lipid markers analysis. After 8 weeks of training the wall squat (s) (T0= 27.18±4.21; T1= 41.68±5.38, p ≤0.01) and Time Up and Go test (s) (T0= 7.65±0.43; T1= 6.34±0.38 p ≤0.01) performances improved; lipid markers analysis showed a decrease in Total (mg/dl) (T0= 187.22±15.73; T1= 173.44±13.03, p≤0.05) and LDL (mg/dl) (T0=108±21.08; T1= 95.02±17.99, p<0.05) cholesterol levels. Additionally, the levels of osteocalcin (µg/L), a marker of bone formation increased (T0= 20.88±4.22; T1=23.66±6.24, p<0.05) 25-OH Vitamin D (µg/L) improved after 8 weeks (T0=21.11±7.11; T1=27.66±7.59, p<0.05). High-intensity interval training had an effect on lower limb strength and gait control, improved bone formation, and lipid management, in multiple sclerosis patients.

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Management of Osteoporosis, Fracture and Falls in People with Multiple Sclerosis: Systematic Review of Guidelines

Grech,

Laurence,

Ebeling

et al. 2023

Calcif Tissue Int

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The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis

Cited by 8 publications

References 43 publications

Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

High-Intensity Interval Training improves bone remodeling, lipid profile, and physical function in multiple sclerosis patients

Management of Osteoporosis, Fracture and Falls in People with Multiple Sclerosis: Systematic Review of Guidelines

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