The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction

Arafa, Mohamed; Eid, Hala; Elbadry, Ahmed; Ezz-Eldine, K; Shamloul, Rany

doi:10.1038/sj.ijir.3901518

Cited by 108 publications

(75 citation statements)

References 15 publications

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“…The presence of penile plaques and recent penile curvature were similarly reported by diabetic patients with PD in previous studies [38,39]. Diabetes aggravates the pathogenesis of PD.…”

Section: Discussionsupporting

confidence: 65%

Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt

Salama¹

2013

AJMBR

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Objectives: To document the prevalence of self-reported sexual dysfunctions (SDs) in diabetic type 2 (DM2) men attending the andrology clinic in the Alexandria University hospital. Methods: A retrospective analysis of clinical case records of 276 consecutive DM2 and 100 consecutive non-diabetic (controls) men who reported SDs directly to the andrology clinic was done. Results: The majority of the patients and controls had light manual occupation, low education level and no history of smoking. No patient reported history of alcohol intake. Erectile dysfunction (ED) was frequent in the DM2 patients and the only complaint in 54.7%. The remaining patients had more than one (compound) complaint. ED (42.7%), premature ejaculation (22.1%) and low libido (11.7%) were the most frequent SDs in these compound complaints. They often joined together in the patients. Less frequently reported SDs were anejaculation (7.2%), penile curvature (4.4%), small-sized penis (2.5%) and penile plaques (0.7%). Penile pain and delayed and painful ejaculations were the rarest reported SDs. Conclusion: DM2 men consulting the andrology clinic may present with several different sexual complaints although ED is the most frequent among these. All diabetic men, therefore, should be asked carefully about the probable existence of any variety of SDs during their medical evaluation.

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“…The presence of penile plaques and recent penile curvature were similarly reported by diabetic patients with PD in previous studies [38,39]. Diabetes aggravates the pathogenesis of PD.…”

Section: Discussionsupporting

confidence: 65%

Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt

Salama¹

2013

AJMBR

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“…Arafa et al reported a high proportion (20.3%) of 206 diabetic men with ED as also having PD, identifying diabetes as a potential PD risk factor. 11 …”

Section: Prevalence and Significancementioning

confidence: 99%

“…The impact of alcohol use in PD is unclear, with one study supporting an association, 16 and another, larger study failing to show a relationship. 18 Possible associations with diabetes, hypertension, and/or other cardiovascular conditions have been suggested, 11,16 but other studies have failed to corroborate these findings. 17,18 …”

Section: Etiology and Modifiable Risk Factorsmentioning

confidence: 99%

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

Bilgutay

Pastuszak

2015

Curr Sex Health Rep

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Peyronie’s Disease (PD) is a superficial fibrosing disorder of the penis resulting in plaque formation and penile deformity. Once considered rare, PD has more recently been found in up to 13% of men, and can negatively affect sexual and psychosocial function of both patients and their partners. While the etiology of PD is unclear, it is thought to result from an inciting traumatic event followed by aberrant fibrosis or dysregulated wound healing. The evaluation of men presenting with PD includes a detailed history and physical exam, focusing on the penis in both the flaccid and erect states. PD is often associated with erectile dysfunction (ED), as well as several other comorbidities. Laboratory testing is not needed to diagnose PD, although given the associations between PD and systemic diseases including hypogonadism, diabetes, and cardiovascular disease, screening and work-up for these conditions in men with PD may be warranted. Treatment modalities for PD are diverse and include oral, topical, intralesional, mechanical, and surgical therapies. Oral, topical, and mechanical therapies generally have little evidence supporting their efficacy. Several intralesional therapies, including interferon α2b and collagenase Clostridium hystiolyticum have demonstrated efficacy in the treatment of PD. Surgical treatment, indicated in men with significant, stable deformity, includes plication of the tunica albuginea, plaque incision/excision and grafting, and placement of inflatable penile prosthesis (IPP) with or without additional maneuvers to achieve desired results, and has high success rates.

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“…Peyronie's disease, which may be associated with sexual dysfunction, is more common in diabetes, with a higher incidence related to a longer duration of diabetes and poor glycaemic control. 37 …”

Section: Diabetes and Other Sexual Dysfunctionsmentioning

confidence: 99%

Erectile dysfunction, diabetes and cardiovascular risk

Hackett

2016

Br J Diabetes

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Erectile dysfunction (ED) occurs in up to 75% of men with type 2 diabetes (T2DM) and has a complex pathogenesis owing to a combination of microvascular, macrovascular, endocrine and neuropathic disease. ED is established as an independent marker for the development of coronary artery disease (CAD) occurring on average 3 -5 years before the onset of CAD. Thus, timely detection of ED offers an opportunity for early intervention, thereby reducing morbidity associated with CAD. The average UK male, however, suffers for 3 years before discussing symptoms of ED with a healthcare professional. The National Institute for Health and Care Excellence (NICE) recommends an annual review of ED symptoms in susceptible patients with T2DM with an appropriate discussion of management options. Screening questions regarding ED were introduced in the 2013 Quality Outcome Framework but were removed by NHS England in 2014 on grounds of 'simplification'. Response to treatment strategies for ED is poor in diabetes, and poor glycaemic control, long duration of disease and severity of complications is predictive of a poor treatment response. The concomitant presence of hypogonadism in over 40% of men with T2DM also makes ED difficult to treat in this group. Further, ED and severe hypogonadism have been shown to independently predict mortality in T2DM. Treatment for ED is more likely to be effective if given early, although complex regimens may be required. Br J Diabetes 2016;16:52-57

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The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction

Cited by 108 publications

References 15 publications

Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt

Sexual Dysfunctions as Self-Reported by Diabetic- Type-2 Men: An Andrology Clinic-Based Study in Alexandria, Egypt

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

Erectile dysfunction, diabetes and cardiovascular risk

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