The Prevalence of Porcine Circovirus-like Viruses in China Presents New Challenges to the Diagnosis of Diarrhea-Associated Viruses. Comment on Yang et al. Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021. Viruses 2021, 13, 2282

Zeng, Meng; Ji, Chihai; Sun, Yi-Ming; Ma, Jingyun

doi:10.3390/v14050962

Cited by 1 publication

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“…Yang et al (2021) detected PCL virus in a dead sow with porcine epidemic diarrhea virus (PEDV) in Anhui Province. In addition to PEDV, pigs infected with PCL virus are also co-infected with viruses such as porcine circovirus type 2 (PCV-2), porcine parvovirus (PPV; Sun et al, 2021;Yang et al, 2021;Zeng et al, 2022). In this study, PCL virus was detected for the first time and in pregnant sows in Hunan Province, which greatly enriched the epidemiological information of PCL virus.…”

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confidence: 73%

Genetic characterization of four strains porcine circovirus-like viruses in pigs with diarrhea in Hunan Province of China

Zeng²,

Wei³

et al. 2023

Front. Microbiol.

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In this study, we detected a circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA virus [named Po-Circo-like (PCL) virus] in intestinal tissue and fecal samples of pigs. PCL virus contains a single-stranded DNA genome, and ORF1 encodes the Rep and not the typical capsid protein encoded in PCV. The Rep protein may be responsible for viral genome replication. In addition, PCL virus may be one of the pathogens causing diarrhea symptoms in pigs. We identified four strains of PCL virus in two different pig farms with severe diarrhea outbreaks in Hunan Province, China. The strains in this study share 85.7–99.7% nucleic acid identity and 84.7–100% amino acid identity with Rep of the reference strains. A multiple sequence alignment of these PCL viruses and Bo-Circo-like CH showed a identity of 93.2% for the Rep protein, and the nucleotide identity was 86.7–89.3%. Moreover, Bo-Circo-like CH and HN75, HN39-01, HN39-02 had similar stem-loop sequences. In conclusion, the present study is the first detailed report of the PCL virus in Hunan provinces, which is a potential new virus in pigs that might be involved in cross-species transmission. Further investigation is needed to determine the pathogenesis of this virus and its epidemiologic impact.

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