The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review

Kleykamp, Bethea A.; Ferguson, McKenzie C; McNicol, Ewan D; Bixho, Ida; Arnold, Lesley M.; Edwards, Robert R.; Fillingim, Roger B.; Grol-Prokopczyk, Hanna; Turk, Dennis C.; Dworkin, Robert H.

doi:10.1016/j.semarthrit.2020.10.006

Cited by 109 publications

(97 citation statements)

References 51 publications

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“…Notably, MFP and FM did not differ significantly regarding the number of comorbidities they presented with. Self-reported somatic symptoms disorder and depression differed the most between MYA, MFP, and FM, which coincides with similar previous research in patients with and without widespread pain [ 15 , 22 , 37 , 38 ]. For instance, previous findings show that 88.9% with FM and 28.5–76.6% with TMD (unknown sub-diagnosis) presented with moderate to severe somatic symptoms [ 39 , 40 ].…”

Section: Discussionsupporting

confidence: 91%

Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia

Barjandi

Hedenberg-Magnusson

Velly

et al. 2021

JCM

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The impact of comorbidities in fibromyalgia (FM) and temporomandibular disorders (TMD) have been well documented, but whether TMD sub-diagnoses myalgia (MYA) and myofascial pain with referral (MFP) differ regarding comorbidity is unclear. We aimed to elucidate this by studying the presence and associations of comorbidities in FM, MFP and MYA. An extended version of the Diagnostic Criteria for TMD axis II questionnaire was used to examine demographics, pain and comorbidities in 81 patients with FM, 80 with MYA, and 81 with MFP. Patients with MFP and FM reported a higher percentage of irritable bowel syndrome (IBS), depression, anxiety, somatic symptoms, perceived stress, and insomnia compared to MYA. Patients with FM had more IBS, depression, and somatic symptom disorder versus MFP. After adjusting for confounding variables, participants with anxiety, somatic symptoms disorder, pain catastrophizing, and perceived stress, as well as a greater number of comorbidities, were more likely to have MFP than MYA, whereas FM participants were more associated with IBS, somatic symptoms and insomnia compared to MFP. The number of comorbidities was significantly associated with widespread pain but not pain duration, body mass index or being on sick leave. In conclusion, patients with MFP were more similar to those with FM regarding comorbidity and should be differentiated from MYA in clinical settings and pain management.

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Section: Discussionsupporting

confidence: 91%

Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia

Barjandi

Hedenberg-Magnusson

Velly

et al. 2021

JCM

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show abstract

“…This study examined the mediating role of depressive symptoms in the relationship between pain intensity and four domains of objective physical performance. The prevalence of depressive symptoms found in this study was within previously reported ranges (Kleykamp et al, 2021). Pain, a central component to FM, is associated with reduced physical function among the FM population (Dailey et al, 2016; Torma et al, 2013).…”

Section: Discussionsupporting

confidence: 90%

Pain intensity and physical performance among individuals with fibromyalgia in mid-to-late life: The influence of depressive symptoms

2021

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This study investigated the mediating role of depressive symptoms among 147 middle-aged and older adults with FM in the relationship between pain intensity and 4 objective measures of physical performance: Fullerton Advanced Balance scale (FAB), 6-Minute Walk Test (6MWT), 30-Second Chair Stand (30SCS), and 8-Foot Up and Go Test (8FUPGT). Asymptotic mediation analyses revealed that depressive symptoms fully mediated the relationship between pain intensity and FAB (95% CI [−0.40, −0.10]) and 8FUPGT (CI [0.02, 0.11]) and partially mediated the relationship to 6MWT (CI [−9.15, −2.20]) and 30SCS (CI [−0.29, −0.06]). Findings support the evaluation of co-morbid depression in FM.

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“…However, comorbidities have not been well investigated in chronic pain conditions, except for psychiatric ones. Recently, it has been reported that there is an association between rheumatic and psychiatric disorders with fibromyalgia [28] as well as between psychiatric and chronic pain comorbidities with fibromyalgia [29]. However, to our knowledge there is a lack of studies regarding somatic comorbidities and the total number of pharmacological medications in pain disorders, including fibromyalgia.…”

Section: Discussionmentioning

confidence: 99%

Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection

Bilevičiūtė-Ljungar

Norrefalk

Borg

2022

JCM

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The global pandemic of SARS-CoV-2 has affected several hundred million people, and many infected people have suffered from a milder initial infection but have never fully recovered. This observational study investigates the pain burden in sufferers of post-COVID-19 syndrome after a milder initial infection. One hundred post-COVID-19 patients filled out questionnaires regarding sociodemographic data, previous comorbidities, present pharmacological treatment, pain intensity and pain localisation. Health-related quality of life, fatigue, emotional status, and insomnia were measured by validated questionnaires. Multiple post-COVID-19 symptoms, including post-exertional malaise, were evaluated by a symptom questionnaire. Among the 100 participants (mean age 44.5 years), 82% were women, 61% had higher education, and 56% were working full or part time. Nine participants reported previous pain or inflammatory conditions. Among the most painful sites were the head/face, chest, lower extremities, and migrating sites. Generalised pain was self-reported by 75 participants and was estimated in 50 participants. Diagnosis of fibromyalgia according to the 2016 criteria was suspected in 40 participants. Subgroup analyses indicated that comorbidities might play a role in the development of pain. In conclusion, a major part of sufferers from post-COVID-19 syndrome develop pain, and in addition to its many disabling symptoms, there is an urgent need for pain management in post-COVID-19 syndrome.

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The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review

Cited by 109 publications

References 51 publications

Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia

Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia

Pain intensity and physical performance among individuals with fibromyalgia in mid-to-late life: The influence of depressive symptoms

Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection

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