The prevalence of rectal carriage of Klebsiella pneumoniae amongst diabetic patients and their clinical relevance in Taiwan: A five-year prospective study

Huang, Yu-Tsung; Jiang, Ju-Ying; Hsu, Meng-Shiuan; Hsu, Hsin-Sui; Liao, Chun-Hsing; Hsueh, Po-Ren

doi:10.1016/j.jmii.2017.05.009

Cited by 18 publications

(5 citation statements)

References 27 publications

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“…The exact reason for this difference remains unknown. Intestinal carriage of virulent serotypes has been reported in Taiwan, Hong Kong, Singapore, and Korea (Siu et al, 2011;Chung et al, 2013;Huang et al, 2018). A recent study of samples from Madagascar, Cambodia, and Senegal showed a very different pattern of KP carriage (Huynh et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Multicenter Surveillance of Capsular Serotypes, Virulence Genes, and Antimicrobial Susceptibilities of Klebsiella pneumoniae Causing Bacteremia in Taiwan, 2017–2019

2022

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We conducted a longitudinal epidemiological surveillance of hypervirulent Klebsiella pneumoniae (hvKP) in Taiwan. Bacteremic KP isolates collected from 16 hospitals in Taiwan between 2017 and 2019 were collected, and the virulent serotypes (K1, K2, K20, K54, and K57), antimicrobial susceptibilities, and virulence genes of these isolates were investigated. During the 3-year period, 1,310 bacteremic KP isolates were collected, of which 27.5% belonged to virulent serotypes, including K1 (n = 162), K2 (n = 74), K57 (n = 56), K54 (n = 41), and K20 (n = 27). K1 was the most prevalent capsular serotype, with an annual prevalence of 11–15%, and was equally distributed across the four geographic areas. The prevalence of K2 declined significantly in 2019. According to wzi-K typing results, 87% of K1 isolates were classified as wzi-1. Among K2 isolates, wzi-72 (55.4%) and wzi-2 (41.9%) were the most common, whereas wzi-206 was the most prevalent (48.2%) among K57 isolates, followed by wzi-77 (25.0%). Wzi-115 accounted for 85.4% of the K54 isolates, whereas wzi-95 accounted for 92.6% of K20 isolates. rmpA was present in 99.4% of K1, 98.6% of K2, 89.3% of K57, 78.0% of K54, and 84.0% of K20 isolates. rmpA2 was present in 100% of K1 and 98.6% of K2 isolates but was only present in 64.3% of K57, 58.5% of K54, and 74.1% of K20 isolates. K1 remains the dominant hvKP serotype and is associated with most virulence genes in Taiwan. Further studies are required to elucidate the significance of other virulent serotypes.

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Section: Discussionmentioning

confidence: 99%

Multicenter Surveillance of Capsular Serotypes, Virulence Genes, and Antimicrobial Susceptibilities of Klebsiella pneumoniae Causing Bacteremia in Taiwan, 2017–2019

2022

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“…[9] In addition, the majority of diabetic patients exhibit speci c vascular lesions, resulting in reduced blood ow velocity and impeding the mobilization and movement of white blood cells, consequently rendering diabetic patients at high risk for BLA. [10] The average size of the PLA was 40.82 cm²±34.93 cm². The maximum diameter of the PLA at admission indicates a long hospital stay and poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Li,

Sheng

2024

Preprint

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Aims: PLA (pyogenic liver abscess) has become a common disease, but the percentage of positive cultures of PLA is low. This study summarizes methods for empirically guiding the administration of PLA even without culture results. Method: The clinical data, clinical characteristics, drug resistance, and liver abscess culture results of 398 patients with PLA were recorded and analyzed retrospectively. Results: For the new findings, there was a significant correlation between KP (Klebsiella pneumoniae) and a high incidence of right lobe of PLA,(P<0.001); There was significant correlation between E.coli(Escherichia coli) and a high incidence of left lobe of PLA.༈P<0.001༉ Conclusions: In patients with PLA whose abscess lesion was located in the right liver, KP was the first consideration, and a third-generation cephalosporin or third-generation cephalosporin/enzyme inhibitor was started. When the abscess is located in the left liver, the presence of E. coli should be considered, and treatment with third-generation cephalosporin/enzyme inhibitors or carbapenems should be started. When the abscess is located in the caudate liver, the pathogenic bacteria may be Streptococcus. Metronidazole and ampicillin are not recommended as first-line anti-infective agents for PLA.

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“…Previous European studies have shown that Klebsiella pneumoniae and E. coli were the species most frequently responsible for ESBL secretion [3], especially K. pneumoniae, part of the natural intestinal microflora, but regarded as an opportunistic pathogen [4,5]. The colonization of biological tissues by K. pneumoniae frequently causes a large variety of diseases [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of Oregano and Lavender Essential Oils

et al. 2021

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Folk medicine uses wild herbs, especially from the Lamiaceae family, such as oregano and lavender, in the treatment of many diseases. In the present study, we investigated the antibacterial activity of the essential oils of Origanum glandulosum Desf. and Lavandula dentata L. against multidrug-resistant Klebsiella pneumoniae strains. The chemical composition of essential oils and their effect on the ultrastructure of the tested bacteria and on the release of cellular components that absorb at 260 nm were studied. Furthermore, the cytotoxicity and the production of reactive oxygen species in human lymphocytes treated with essential oils were evaluated. Thymol (33.2%) was the major constituent in O. glandulosum, and β-pinene (17.3%) was the major constituent in L. dentata. We observed ultrastructural damage in bacteria and increased release of cellular material. Furthermore, ROS production in human lymphocytes treated with essential oils was lower than in untreated lymphocytes and no cytotoxicity was observed. Therefore, the essential oils of lavender and oregano could be used as a source of natural antibacterial and antioxidant agents with potential pharmacological applications.

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The prevalence of rectal carriage of Klebsiella pneumoniae amongst diabetic patients and their clinical relevance in Taiwan: A five-year prospective study

Cited by 18 publications

References 27 publications

Multicenter Surveillance of Capsular Serotypes, Virulence Genes, and Antimicrobial Susceptibilities of Klebsiella pneumoniae Causing Bacteremia in Taiwan, 2017–2019

Multicenter Surveillance of Capsular Serotypes, Virulence Genes, and Antimicrobial Susceptibilities of Klebsiella pneumoniae Causing Bacteremia in Taiwan, 2017–2019

A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Chemical Composition and Biological Activities of Oregano and Lavender Essential Oils

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