The Prevalence of Resistant Hypertension Among Type 2 Diabetic Patients Attending the National Center for Diabetes, Endocrinology, and Genetics

Mohammad, Abeer; Abujbara, Mousa; Alshraideh, Jafar Alasad; Jaddou, Hashem; Ajlouni, Kamel

doi:10.14740/jem448e

Cited by 4 publications

(4 citation statements)

References 21 publications

(50 reference statements)

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“…An increased body mass index as indicated by overweight and obesity was another important finding which was associated with suboptimal BP control where the prevalence was 56.6% and 63.2%, respectively. This was similar to the findings in Jordan where the prevalence of overweight and obesity was 52.5% and 28.8%, respectively [19].…”

Section: Discussionsupporting

confidence: 91%

“…Uncontrolled blood sugar as shown by HBA1C was 68.2% which can be explained by poor adherence to medication. Elevated cholesterol was found in 50.3%; these findings are almost the same with that of the study done in Jordan (HBA1C (52.5%) and cholesterol (54.9%)) [ 19 ]. Inactivity and consumption of saturated fats in meat and cooking oils are the major factors contributing to dyslipidaemia.…”

Section: Discussionsupporting

confidence: 86%

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Suboptimal Blood Pressure Control, Associated Factors, and Choice of Antihypertensive Drugs among Type 2 Diabetic Patients at KCMC, Tanzania

Mbwete

Kilonzo

Shao

et al. 2020

Journal of Diabetes Research

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Background. Hypertension (HTN) can be present in up to two-thirds of patients living with diabetes mellitus (DM). It is a risk factor for the development of diabetes as well as complications like coronary artery disease (CAD), nephropathy, retinopathy, and neuropathy. Hypertension is treatable, and the degree to which it is controlled determines the risk of development of cardiovascular diseases and other complications in a given individual patient. Even though antihypertensive drugs are available and issued to hypertensive diabetic patients, the rate of control of HTN is often inadequate. The aim of this study was to assess the prevalence of suboptimal blood pressure (BP) control, its associated factors, and the choice of antihypertensive drugs among type 2 DM patients at Kilimanjaro Christian Medical Centre (KCMC). Methods. A hospital-based cross-sectional study was conducted at the KCMC diabetes clinic from October 2018 to March 2019 among type 2 DM patients with HTN based on the inclusion criteria. Data were collected using structured questionnaires, and written informed consent was obtained. Suboptimal BP was defined as BP levels≥140/90 mmHg according to the American Diabetes Association guideline published in 2018. Data analysis was done using the Statistical Package for the Social Sciences (SPSS) version 25. Chi-square analysis was done to identify the independent predictors of BP control, and a p value of <0.05 was considered to be statistically significant. Results. The data of 161 participants was analysed; the mean age was 63.9±20.2 years, with the majority being females (67.1%). Despite all participants being on different classes of antihypertensives, 57.8% had suboptimal BP control. Among the participants with good BP control, 52.7% were on angiotensin-converting enzyme inhibitors (ACE-I). Poor diabetes control was observed in 50.1% participants as indicated by elevated glycated haemoglobin. Conclusion. This study demonstrated that BP control in type 2 DM patients was suboptimal in more than half of the participants. The study showed that the use of ACE-I or angiotensin II receptor blockers (ARBs) in the majority of DM patients has a good impact in the control of blood pressure. The early initiation of ACE-I or ARBs among the diabetic patients will improve the optimal BP control.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Suboptimal Blood Pressure Control, Associated Factors, and Choice of Antihypertensive Drugs among Type 2 Diabetic Patients at KCMC, Tanzania

Mbwete

Kilonzo

Shao

et al. 2020

Journal of Diabetes Research

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“…This percentage is remarkably less than our population, in which 43.07% of resistant hypertension patients had IHD. On the other hand, Mohammad A et al reported that 54.6% (77/141) of resistant hypertension patients had IHD [11]. Our data resource could explain our results since most data were from a cardiac center.…”

Section: Discussionmentioning

confidence: 48%

“…Our study's prevalence of resistant hypertension in patients with T2DM was consistent with other studies. Solini A et al reported a prevalence of 17% in Italy [10], and Mohammad A et al reported a prevalence of 16% in Jordan [11]. These articles reported a significant association between resistant hypertension and T2DM.…”

Section: Discussionmentioning

confidence: 99%

Resistant Hypertension in Patients With Type-2 Diabetes Mellitus: A Single-Center, Cross-Sectional Study

Binaqeel¹,

Filimban²,

Bafageeh³

et al. 2022

Cureus

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BackgroundThe prevalence of resistant hypertension in Saudi patients with type-2 diabetes mellitus (T2DM) has not been previously estimated. Therefore, our objective was to assess the prevalence and characteristics of resistant hypertensive patients with T2DM at King Abdulaziz Medical City, Jeddah, Saudi Arabia. MethodsThis cross-sectional study included patients with hypertension and T2DM who presented to our center in 2018. We examined 1960 patients with T2DM during the study period; 809 were hypertensives. We compared T2DM patients with controlled hypertension versus resistant hypertension. ResultsThe prevalence of resistant hypertension in patients with T2DM was 137/809 (16.93%). The mean age was 66.38±10.80 years, and females presented 56% of the study population (n= 451). Obstructive sleep apnea (OSA; OR: 2.60 [1.15-5.87]; P=0.02) and ischemic heart disease (IHD; OR: 3.01 [2.04-4.45]; P˂0.001) were significantly associated with resistant hypertension. The most common medications used with resistant hypertension were calcium channel blockers (CCBs; 89.05%), β-blockers (76.64%), and angiotensin-2 receptor blockers (ARBs; 62.77%). ConclusionsResistant hypertension in patients with T2DM is common in Saudi Arabia. Resistant hypertension could be associated with OSA and IHD. Further studies are required to evaluate the temporal relationship between resistant hypertension and risk factors.

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Prevalence of hypertension among type 2 diabetes mellitus patients in Ethiopia: a systematic review and meta-analysis

Haile

Mariye

Tadesse

et al. 2022

International Health

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Background Hypertension among diabetic patients is a worldwide public health challenge and a leading modifiable risk factor for other cardiovascular diseases and death. This study aimed to estimate the prevalence of hypertension among diabetic patients in Ethiopia. Methods The studies were selected using PubMed, Embase, Health InterNetwork Access to Research Initiative and Cochrane Library databases and Google searches. Two independent authors carried out the data extraction using a predetermined and structured method of data collection. R version 3.5.3 and RStudio version 1.2.5003 were used for analysing the data. To assess possible publication bias, funnel plot test methods were used. The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses were used to publish the results. This study was registered in the Prospective Register Systematic Reviews (CRD42020170649). Results A total of 218 articles were identified but only 6 six full-text abstract papers were included in this systematic review and meta-analysis. The random effects model analysis showed that the pooled prevalence of hypertension among type 2 diabetes mellitus (DM) patients in Ethiopia was 55% (95% confidence interval [CI] 49 to 61). The subgroup analysis of the pooled prevalence of hypertension among type 2 DM patients in the Oromia and Southern regions was 51% (95% CI 42 to 59) and 58% (95% CI 54 to 63), respectively. The pooled prevalence of hypertension among type 2 DM patients was higher among urban residents (60% [95% CI 54 to 67] and 52% [95% CI 41 to 63] among urban and rural residents, respectively). Conclusions This study showed a high pooled prevalence of hypertension among type 2 DM patients in Ethiopia. Appropriate preventive measures should be implemented to reduce the burden of hypertension among DM patients in Ethiopia.

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The Prevalence of Resistant Hypertension Among Type 2 Diabetic Patients Attending the National Center for Diabetes, Endocrinology, and Genetics

Cited by 4 publications

References 21 publications

Suboptimal Blood Pressure Control, Associated Factors, and Choice of Antihypertensive Drugs among Type 2 Diabetic Patients at KCMC, Tanzania

Suboptimal Blood Pressure Control, Associated Factors, and Choice of Antihypertensive Drugs among Type 2 Diabetic Patients at KCMC, Tanzania

Resistant Hypertension in Patients With Type-2 Diabetes Mellitus: A Single-Center, Cross-Sectional Study

Prevalence of hypertension among type 2 diabetes mellitus patients in Ethiopia: a systematic review and meta-analysis

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