PURPOSE This pilot study aimed to determine whether raw milk reduces lactose malabsorption and/or lactose intolerance symptoms relative to pasteurized milk.
METHODSWe performed a crossover trial involving 16 adults with self-reported lactose intolerance and lactose malabsorption confirmed by hydrogen (H 2 ) breath testing. Participants underwent 3, 8-day milk phases (raw vs 2 controls: pasteurized, soy) in randomized order separated by 1-week washout periods. On days 1 and 8 of each phase, milk consumption was 473 mL (16 oz); on days 2 to 7, milk dosage increased daily by 118 mL (4 oz), beginning with 118 mL (4 oz) on day 2 and reaching 710 mL (24 oz) on day 7. Outcomes were area under the breath H 2 curve (AUC ∆H 2 ) and self-reported symptom severity (visual analog scales: flatulence/gas, audible bowel sounds, abdominal cramping, diarrhea).RESULTS AUC ∆H 2 (mean ± standard error of the mean) was higher for raw vs pasteurized on day 1 (113 ± 21 vs 71 ± 12 ppm·min·10 -2 , respectively, P = .01) but not day 8 (72 ± 14 vs 74 ± 15 ppm·min·10 -2 , respectively, P = .9). Symptom severities were not different for raw vs pasteurized on day 7 with the highest dosage (P >.7). AUC ∆H 2 and symptom severities were higher for both dairy milks compared with soy milk.CONCLUSIONS Raw milk failed to reduce lactose malabsorption or lactose intolerance symptoms compared with pasteurized milk among adults positive for lactose malabsorption. These results do not support widespread anecdotal claims that raw milk reduces the symptoms of lactose intolerance.
INTRODUCTIONL actose malabsorption is an extremely common condition worldwide, and its incidence increases with age and varies between ethnicities. 1,2 Bacteria in the colon ferment undigested lactose into short-chain fatty acids, hydrogen, methane, and carbon dioxide, resulting in such symptoms as bloating, abdominal pain, and/or diarrhea after ingestion of lactose. 1 National Institutes of Health (NIH) consensus development panel defined lactose intolerance as a clinical syndrome characterized by the onset of gastrointestinal symptoms following a lactose challenge, 3 whereas true lactose malabsorption is identified through a hydrogen breath test (HBT). Many people with lactose malabsorption do not report clinical lactose intolerance. 4,5 Conversely, many individuals with perceived lactose intolerance do not experience malabsorption. 6 Because of inconsistent definitions in previous studies, the true prevalence of lactose intolerance is unknown.
7Strategies to reduce unpleasant gastrointestinal symptoms associated with lactose intolerance include (1) choosing lactose-free or reduced-lactose dairy foods, [8][9][10][11] (2) choosing fermented dairy foods, 11-13 (3) combining lactose intake with a meal, [14][15][16] (4) taking lactase enzyme tablets, 10,11,17 (5) consuming probiotics, 11,[18][19][20] (6) colonic adaptation, [21][22] and (7)
135NIH highlighted the need for further studies evaluating the effectiveness of interventions addressing lactose intolerance. 3,7 Rece...