The prevalence of serum magnesium and iron deficiency anaemia among Sudanese women in early pregnancy: a cross-sectional study

Eltayeb, Reem; Rayis, Duria A.; Sharif, Manal E.; Ahmed, Abdul; Elhardello, Osama

doi:10.1093/trstmh/try109

Cited by 19 publications

(23 citation statements)

References 28 publications

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“…In addition, the dietary pattern (traditional vs. modern pattern) was analyzed in elderly subjects, and a positive association was found between the traditional dietary pattern and anemia with the influence of serum Mg 2+ [ 142 ]. A cross-sectional study with 180 pregnant women (up to 14 weeks of gestation) from Khartoum in Sudan, showed that 65.0% and 57.2% had anemia and Mg 2+ deficiency, respectively, and that low levels of serum ferritin and Mg 2+ were associated with anemia [ 49 ]. On the other hand, Mg 2+ supplementation seems to increase the hemoglobin levels and counts of erythrocytes [ 50 ].…”

Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue.

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Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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“…In these studies, magnesium de ciency was determined using cut-offs between 0.76 mmol/L and 0.85 mmol/L [23,24,2,25]. High rates of hypomagnesemia have been reported in pregnant women in India (43.6%) and Sudan (57.2%); both studies used a cut-off of 0.74 mmol/L [26,27]. The results of the present study con rm the general observations that pregnant women, women receiving oral contraceptives, postmenopausal women and women with osteoporosis are at a particular risk of hypomagnesemia [16,9,17].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Comorbidities Associated With Magnesium Deficiency in Pregnant Women and Women With Hormone-related Conditions: Analysis of a Large Real-world Dataset

Orlova¹,

Dikke

Pickering

et al. 2020

Preprint

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Purpose An accumulating body of literature indicates that magnesium deficiency is associated with a number of hormone-related conditions (HRC) in women, and epidemiological studies are needed to assess its prevalence and risk factors. Here, we present a secondary analysis of data pooled from four large observational studies that assessed magnesium deficiency among pregnant women and women with HRC across the Russian Federation. Methods The main objective of this analysis was to estimate the prevalence of magnesium deficiency in this population and to describe risk factors and comorbidities associated with low serum magnesium. Univariate logistic regression analysis was performed to identify the risk factors and comorbid conditions associated with an increased risk of low serum magnesium level. Results A total of 983 pregnant women and 9444 women with HRC were eligible for analysis. Prevalence of hypomagnesemia (magnesium serum level cut-off < 0.66 mmol/L/<0.8 mmol/L) was 34.0%/78.9% in pregnant women and 21.4%/54.8% in women with HRC. The highest prevalence of magnesium deficiency was observed for osteoporosis and climacteric syndrome. Risk factors included diastolic blood pressure, previous pregnancy complications, infections and edema for pregnant women, and age, body mass index, and various comorbidities for women with HRC. Conclusions These results confirm the importance of magnesium in various aspects of women’s health and support the use of magnesium supplementation in populations at risk.

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“…In these studies, magnesium de ciency was determined using cut-offs between 0.76 mmol/L and 0.85 mmol/L [2,[23][24][25]. High rates of hypomagnesemia have been reported in pregnant women in India (43.6%) and Sudan (57.2%); both studies used a cut-off of 0.74 mmol/L [26,27]. The results of the present study con rm the general observations that pregnant women, women receiving oral contraceptives, postmenopausal women and women with osteoporosis are at a particular risk of hypomagnesemia [9,16,17].…”

Section: Discussionmentioning

confidence: 99%

Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset

Orlova¹,

Dikke

Pickering

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundAn accumulating body of literature indicates that magnesium deficiency is associated with a number of hormone-related conditions (HRC) in women, and epidemiological studies are needed to assess its prevalence and risk factors. Here, we present a secondary analysis of data pooled from four large observational studies that assessed magnesium deficiency among pregnant women and women with HRC across the Russian Federation.MethodsThe main objective of this analysis was to estimate the prevalence of magnesium deficiency in this population and to describe risk factors and comorbidities associated with low serum magnesium. Univariate logistic regression analysis was performed to identify the risk factors and comorbid conditions associated with an increased risk of low serum magnesium level.ResultsA total of 983 pregnant women and 9444 women with HRC were eligible for analysis. Prevalence of hypomagnesemia (magnesium serum level cut-off <0.66 mmol/L/<0.8 mmol/L) was 34.0%/78.9% in pregnant women and 21.4%/54.8% in women with HRC. The highest prevalence of magnesium deficiency was observed for osteoporosis and climacteric syndrome. Risk factors included diastolic blood pressure, previous pregnancy complications, infections and edema for pregnant women, and age, body mass index, and various comorbidities for women with HRC.ConclusionsThese results confirm the high prevalence of hypomagnesemia in pregnant women and women with HRC and underline the importance of routine screening, since risk factors are mostly non-specific.

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The prevalence of serum magnesium and iron deficiency anaemia among Sudanese women in early pregnancy: a cross-sectional study

Cited by 19 publications

References 28 publications

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Risk Factors and Comorbidities Associated With Magnesium Deficiency in Pregnant Women and Women With Hormone-related Conditions: Analysis of a Large Real-world Dataset

Risk factors and comorbidities associated with magnesium deficiency in pregnant women and women with hormone-related conditions: Analysis of a large real-world dataset

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