The prevalence of sessile serrated lesion in the colorectum and its relationship to synchronous colorectal advanced neoplasia: a systemic review and meta-analysis

Shiu, Sz‐Iuan; Kashida, Hiroshi; Komeda, Yoriaki

doi:10.1097/meg.0000000000002062

Cited by 6 publications

(10 citation statements)

References 39 publications

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“…Regarding ethnicity, the present study is the first, to our knowledge, to investigate the prevalence of serrated polyps in the Asian population. Meta-analyses of the non-IBD population have reported that the prevalence of serrated polyps in Western countries was higher than those in Eastern countries [33,34]. The possible reason for the similar proportions of serrated polyps in patients with UC between the present study and previous studies is differences in the study periods.…”

Section: Plos Onesupporting

confidence: 53%

Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biological characteristics

et al. 2023

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Background Serrated polyps have recently been reported in patients with ulcerative colitis (UC); however, their prevalence and detailed characteristics remain unclear. Methods The prevalence and clinicopathological and biological characteristics of serrated polyps in patients with UC were retrospectively examined in a single tertiary inflammatory bowel disease center in Japan from 2000 to 2020. Results Among 2035 patients with UC who underwent total colonoscopy, 252 neoplasms, including 36 serrated polyps (26 in colitis-affected segments, 10 in colitis-unaffected segments), were identified in 187 patients with UC. The proportion of serrated polyps was 1.8% (36/2035). Serrated polyps in colitis-affected segments were common with extensive colitis (88%), history of persistent active colitis (58%), and long UC duration (12.1 years). Serrated polyps in colitis-affected segments were more common in men (88%). Of the 26 serrated polyps in colitis-affected segments, 15, 6, and 5 were categorized as sessile serrated lesion-like dysplasia, traditional serrated adenoma-like dysplasia, and serrated dysplasia not otherwise specified, respectively. Sessile serrated lesion-like dysplasia was common in the proximal colon (67%) and with BRAF mutation (62%), whereas traditional serrated adenoma-like dysplasia and serrated dysplasia not otherwise specified were common in the distal colon (100% and 80%, respectively) and with KRAS mutations (100% and 75%, respectively). Conclusions Serrated polyps comprised 14% of the neoplasias in patients with UC. Serrated polyps in colitis-affected segments were common in men with extensive and longstanding colitis, suggesting chronic inflammation in the development of serrated polyps in patients with UC.

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Section: Plos Onesupporting

confidence: 53%

Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biological characteristics

et al. 2023

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“…S SLS ARE MOST frequently found proximal to the splenic flexure. 25 Shiu et al 26 reported that the prevalence of SSLs was only 2.7%. SSLs with advanced histology are rarer, and the frequencies of SSL with dysplasia and invasive carcinoma were reported to range from 1% to 14% and from 0.2% to 1.0%, respectively.…”

Section: Clinicopathological Characteristics Of Sslsmentioning

confidence: 99%

“…SSLs are most frequently found proximal to the splenic flexure 25 . Shiu et al 26 . reported that the prevalence of SSLs was only 2.7%.…”

Section: Clinicopathological Characteristics Of Sslsmentioning

confidence: 99%

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management

Murakami

Kurosawa

Fukushima

et al. 2022

Digestive Endoscopy

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The 2019 World Health Organization (WHO) Classification of Tumours of the Digestive System (5th edition) introduced the term "sessile serrated lesion" (SSL) to replace the term "sessile serrated adenoma/polyp" (SSA/P). SSLs are early precursor lesions in the serrated neoplasia pathway that result in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a CpG island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potential. The 2019 WHO classification noted that dysplasia arising in an SSL most likely is an advanced polyp, regardless of the morphologic grade of the dysplasia. Detecting SSLs with or without dysplasia is critical; however, detection of SSLs is challenging, and their identification by endoscopists and pathologists is inconsistent. Furthermore, indications for their endoscopic treatment have not been established. Moreover, SSLs are considered to contribute to the development of postcolonoscopy colorectal cancers. Herein, the clinicopathological and endoscopic characteristics of SSLs, including features determined using white light and image-enhanced endoscopy, therapeutic indications, therapeutic methods, and surveillance are reviewed based on the literature. This information may lead to more intensive research to improve detection, diagnosis, and rates of complete resection of these lesions and reduce post-colonoscopy colorectal cancer rates.

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“…The test images were composed of 20 LST‐NG (size range 10–55 mm), 10 depressed (IIc) lesions (3–13 mm), 10 large SSLs (10–25 mm), five polypoid lesions (3–10 mm), and 15 had no lesions. Among FDLs, we included LST‐NG more than the other types, considering the actual prevalence of each FDL 3,27,28 . With the black arrows on the outside of the image, each image was virtually divided into three areas (upper, middle, and lower) for readers to help understand the main area of the detected lesion in the image (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Among FDLs, we included LST-NG more than the other types, considering the actual prevalence of each FDL. 3,27,28 With the black arrows on the outside of the image, each image was virtually divided into three areas (upper, middle, and lower) for readers to help understand the main area of the detected lesion in the image (Fig. 2).…”

Section: Selection Of the Test Imagesmentioning

confidence: 99%

Efficacy of international web‐based educational intervention in the detection of high‐risk flat and depressed colorectal lesions higher (CATCH project) with a video: Randomized trial

Iwatate

Hirata

Francisco

et al. 2022

Digestive Endoscopy

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Objectives: Three subcategories of high-risk flat and depressed lesions (FDLs), laterally spreading tumors nongranular type (LST-NG), depressed lesions, and large sessile serrated lesions (SSLs), are highly attributable to postcolonoscopy colorectal cancer (CRC). Efficient and organized educational programs on detecting high-risk FDLs are lacking. We aimed to explore whether a web-based educational intervention with training on FIND clues (fold deformation, intensive stool/mucus attachment, no vessel visibility, and demarcated reddish area) may improve the ability to detect high-risk FDLs.Methods: This was an international web-based randomized control trial that enrolled non-expert endoscopists in 13 Asian countries. The participants were randomized into either education or non-education group. All participants took the pre-test and post-test to read 60 endoscopic images (40 high-risk FDLs, five polypoid, 15 no lesions) and answered whether there was a lesion. Only the education group received a self-education program (video and training questions and answers) between the tests. The primary outcome was a detection rate of high-risk FDLs.Results: In total, 284 participants were randomized. After excluding non-responders, the final data analyses were based on 139 participants in the education group and 130 in the noneducation group. The detection rate of high-risk FDLs in the education group significantly improved by 14.7% (66.6-81.3%) compared with À0.8% (70.8-70.0%) in the non-education group. Similarly, the detection rate of LST-NG, depressed lesions, and large SSLs significantly increased only in the education group by 12.7%, 12.0%, and 21.6%, respectively.

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The prevalence of sessile serrated lesion in the colorectum and its relationship to synchronous colorectal advanced neoplasia: a systemic review and meta-analysis

Cited by 6 publications

References 39 publications

Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biological characteristics

Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biological characteristics

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management

Efficacy of international web‐based educational intervention in the detection of high‐risk flat and depressed colorectal lesions higher (CATCH project) with a video: Randomized trial

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