The prevalence of symptomatic knee osteoarthritis in China: Results from China Health and Retirement Longitudinal Study

Tang, Xiaoyan; Wang, Shuguang; Zhang, Y.; Niu, Jingbo; Tao, Ke; Lin, Jian

doi:10.1016/j.joca.2015.02.949

Cited by 95 publications

(124 citation statements)

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“…For the people over 60 years old, the incidence of OA reaches as high as 42.8%. 3 In the early stages, the treatment of OA focuses on pain relief and symptom control. 4,5 In the advanced stage, there will be activity disorders and even disability, and joint replacement surgery will be the only therapeutic option.…”

Section: Introductionmentioning

confidence: 99%

LncRNA PART‐1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR‐590‐3p sponge in osteoarthritis

Lü

et al. 2019

J Cellular Molecular Medi

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Osteoarthritis (OA) is a degenerative joint disease that commonly occurs in the elderly. This study focused on apoptosis and explored the modulating effects of long non‐coding (lncRNAs) prostate androgen‐regulated transcript‐1 (PART‐1) on chondrocytes apoptosis. In the present study, the PART‐1 expression level was down‐regulated in the OA cartilages. Silence of PART‐1 decreased the cell viability and promoted chondrocytes apoptosis. Overexpression of PART‐1 could reverse the effects induced by interleukin 1β (IL‐1β) stimulation, thus slowing down the apoptosis rate. MiR‐590‐3p was found to be the potential target, and RNA immunoprecipitation and luciferase activity assay confirmed the binding between PART‐1 and miR‐590‐3p. Moreover, miR‐590‐3p was down‐regulated by PART‐1 and was negatively associated with PART‐1. Transforming growth factor‐beta receptor type 2 (TGFBR2) was positively associated with PART‐1. Down‐regulation of PART‐1 decreased cell viability and induced cell apoptosis, which was partially reversed by miR‐590‐3p silence or TGFBR2 overexpression; while overexpression of PART‐1 increased the cell viability and decreased the caspase 3 activity and apoptotic rates, and the effects were partially attenuated by miR‐590‐3p overexpression or silence of TGFBR2 in IL‐1β‐stimulated chondrocytes. Knock‐down of PART‐1 down‐regulated both Smad3 and p‐Smad3 protein levels, which was reversed by miR‐590‐3p inhibition or TGFBR2 overexpression. Smad3 expression level was lower in the OA group than that in the normal group and was positively associated with the PART‐1 expression level. Collectively, the study revealed that lncRNA PART‐1 regulates the apoptosis of chondrocytes in OA by acting as a sponge for miR‐590‐3p, which subsequently regulates TGFBR2/Smad3 signalling.

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Section: Introductionmentioning

confidence: 99%

LncRNA PART‐1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR‐590‐3p sponge in osteoarthritis

Lü

et al. 2019

J Cellular Molecular Medi

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“…Previous study showed that about 120 million people in China are suffering from OA and more than half of them are over 60 years old. Besides, the incidence of OA in female is higher than that in male [2]. OA is a kind of aseptic inflammatory disease, and its pathogenesis is considered as a specific immune response.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Lycium barbarum polysaccharide alleviates IL-1β-evoked chondrogenic ATDC5 cell inflammatory injury through mediation of microRNA-124

Wang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Lycium barbarum polysaccharide (LBP) is a promising therapeutic drug in inflammationrelated injuries, nevertheless the mechanism of LBP's action is still elusive. The study is to explore the effect of LBP on IL-1b-evoked ATDC5 cell inflammatory injury. Methods: ATDC5 cells were administrated with 10 ng/mL interleukin (IL)-1b to establish an in vitro model of cartilage damage. After management, cell viability was tested through CCK8 assay. The proinflammatory cytokines and cyclooxygenase (Cox)-2 were assessed through ELISA, western blot and qRT-PCR. MiR-124 expression in ATDC5 cells was silenced by transfecting with miR-124 inhibitor, and the pro-inflammatory cytokines and Cox-2 were reassessed. NF-jB and JNK pathways were measured through western blot. Results: IL-1b stimulation accelerated the release of IL-1b, IL-6 and TNF-a, elevated Cox-2 expression. LBP significantly eased IL-1b-induced inflammation. MiR-124 expression was observed to enhance by LBP, and the impacts of LBP on ATDC5 cells were lightened via transfection with miR-124 inhibitor. NF-jB and JNK pathways were activated after IL-1b stimulation, nevertheless were inactivated by LBP administration. Besides, LBP-evoked the repression of NF-jB and JNK pathways were overturned by miR-124 inhibitor. Conclusions: Our study suggests that LBP protects ATDC5 cells from IL-1b-evoked injury through upregulating miR-124 via blocking NF-jB and JNK pathways.

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“…2 The incidence rate of OA is highest in the knee (knee osteoarthritis, KOA). 3 The elderly and women have a greater risk of developing OA. 4 With an increase in the aging population in China, KOA has become the most common and important joint disease and also one of the major causes of disability.…”

Section: Introductionmentioning

confidence: 99%

“…4 With an increase in the aging population in China, KOA has become the most common and important joint disease and also one of the major causes of disability. 3,[5][6][7][8][9] The disability rate is as high as 53%. According to the Global Burden of Disease 2010 study, 10 hip and knee OA was ranked as the 11th highest contributor to disability, with a worldwide KOA prevalence of 3.8%.…”

Section: Introductionmentioning

confidence: 99%

Effects of quadriceps functional exercise with isometric contraction in the treatment of knee osteoarthritis

Huang

Guo

et al. 2017

Int J of Rheum Dis

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The prevalence of symptomatic knee osteoarthritis in China: Results from China Health and Retirement Longitudinal Study

Abstract: Purpose: Vigorous physical activity is often considered a risk factor for knee and hip osteoarthritis (OA), but its effect on spinal OA is poorly

Cited by 95 publications

References 0 publications

LncRNA PART‐1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR‐590‐3p sponge in osteoarthritis

LncRNA PART‐1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR‐590‐3p sponge in osteoarthritis

RETRACTED ARTICLE: Lycium barbarum polysaccharide alleviates IL-1β-evoked chondrogenic ATDC5 cell inflammatory injury through mediation of microRNA-124

Effects of quadriceps functional exercise with isometric contraction in the treatment of knee osteoarthritis

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