The prevalence of syphilis in HIV-seropositive patients: a retrospective study at the regional hospital in Agadir, Morocco

Bourouache, M.; Mimouni, R.; Nejmeddine, Mohamed; Chadli, Smail; Benlmeliani, Fatima; Sardi, Jamila; Malmoussi, M; Ouagari, Zineb; Basbassi, Maryam El; Aghrouch, Mohamed

doi:10.11604/pamj.2019.33.252.15781

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…It is encouraging that the reported prevalence of syphilis in this study is similar to the prevalence of syphilis among PLHIV reported in Ethiopia [ 23 ]. Although the prevalence of syphilis in our study may have been overestimated due to the limitations of the test kits in reacting to non-treponemal infections, studies in other African countries such as Nigeria (14.0%), Ghana (14.8%), Morocco (16.4%), Chad (14.0%), and Tanzania (9.6%) reported a higher prevalence [ 8 – 10 , 24 – 26 ]. The disparities in these findings may be due to the different composition of the study populations and differences in the methods applied for the detection of syphilis or perhaps may reflect the variations in the risky behavioral practices across the African region.…”

Section: Discussionmentioning

confidence: 59%

“…However, the global effort to eliminate syphilis as a major public health problem by 2030 is hampered by several challenges facing the health system in low-income countries [ 7 ]. Consequently, many studies in low-income countries have shown high rates of syphilis among PLHIV, reinforcing the need for robust syphilis screening programs in sub-Saharan Africa [ 8 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Sero-prevalence of syphilis infection among people living with HIV in Sierra Leone: a cross-sectional nationwide hospital-based study

Jiba,

Lakoh,

Wang

et al. 2023

BMC Infect Dis

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Background Globally, there were an estimated 7.1 million new syphilis infections in 2020, with more than 30% of these new infections reported in African countries such as Sierra Leone. Despite this, there is no HIV-specific syphilis screening program in Sierra Leone. Thus, data are needed to inform public health practice. In this study, we aimed to determine the prevalence of syphilis seropositivity and factors associated with syphilis seropositivity among people living with HIV (PLHIV). Methods A cross-sectional study was conducted at 10 health facilities in Sierra Leone, among adults with HIV, aged 18 years or older, from September 2022 to January 2023. Parameters of interest were collected including age, sex, marriage, antiretroviral therapy (ART) regimen, HIV viral load, duration of ART treatment, and hospital level of care. The syphilis antibody was detected by a rapid test based on immunochromatography assay. Data were analyzed using R-software version 4.2.3 (R Core Team, Vienna, Austria). Pearson’s χ2 test, Fisher’s exact test and Kruskal–Wallis H test were applied to assess the differences in syphilis seropositivity between groups as appropriate. Univariate logistic regression and multivariate logistic regression analysis was used to assess factors associated with syphilis seropositivity. The level of statistical significance was set at P < 0.05. Results Of the 3082 PLHIV individuals in our study, 2294 (74.4%) were female and 2867 (93.0%) were receiving ART. With a median age of 36 years, 211 (6.8%, 95% CI 6.0–7.7) were positive for syphilis. The prevalence of syphilis was highest in people aged 60 years and over (21.1%, 95%CI 14.7–29.2), followed by people aged 50–60 years (15.5%, 95%CI 11.9–19.9) and in the widowed population (11.9%, 95%CI 8.9–15.8). There were no differences in syphilis seropositivity between gender, ART status, ART regimen, duration of ART, HIV viral load and hospital level of care. Older age (50–60 years: adjusted OR 3.49, 95%CI 2.09–5.85 P < 0.001; 60–100 years: adjusted OR 4.28, 95%CI 2.21–8.17, P < 0.001) was an independent predictor of seropositive syphilis. Conclusions We observed a high prevalence of syphilis among PLHIV. Older people and widowed population have higher syphilis seropositivity. Older age was an independent predictor of syphilis positivity. Therefore, we call for the integration of syphilis screening, treatment and prevention in HIV services.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Sero-prevalence of syphilis infection among people living with HIV in Sierra Leone: a cross-sectional nationwide hospital-based study

Jiba,

Lakoh,

Wang

et al. 2023

BMC Infect Dis

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“…Despite The World Health Organization’s strategic goal of reducing syphilis incidence by 90% by 2030, 5 this goal is a long way off today, given the data from some at-risk groups. 6,18,19…”

Section: Discussionmentioning

confidence: 99%

“…Despite The World Health Organization's strategic goal of reducing syphilis incidence by 90% by 2030, 5 this goal is a long way off today, given the data from some atrisk groups. 6,18,19 Early diagnosis and treatment of syphilis are very effective strategies for prevention and control of the disease at both the individual and community levels. 20 However, the clinical diagnosis of syphilis can be challenging and misdiagnosis is common because the infection can mimic many other diseases.…”

Section: Discussionmentioning

confidence: 99%

Syphilis and dentists: The data about knowledge and awareness of clinicians in Turkey

Meseli

Pelit

2023

Int J STD AIDS

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Background: Syphilis may give pathognomonic signs in oral cavity. In order to emerge an awareness about dentists’ role in syphilis management, it was aimed to obtain the data from them about their knowledge. Methods: This survey-based, cross-sectional study was conducted with 709 dentists practicing in Turkey. Participants answered 16 statements about syphilis “Transmission Routes,” “Extra-oral Clinical Features,” “Oral Findings,” and “Diagnosis & Treatment” with options yes/no/I do not know. Moreover, they responded to two 5-point Likert type questions about their comfort level and frequency of taking sexual anamnesis. The statistical significance was set at p ≤ .05. Results: The mean age (years) and female/male ratio of the participants were 35.7 ± 10.2 and 449/260, respectively. The average of the correct answers in the survey was 10.38 ± 3.3. “Transmission Routes” had the highest ratio (50.6%) in terms of all questions in a single category that were answered correctly among groups. Dentists practicing at faculties had the highest number of correct answers ( p = .003). The total number of correct answers and the number of correct answers in each category were positively related to both the level of comfort and the frequency of taking patient’s sexual anamnesis (Oral Findings p = .002; others p ≤ .001). Conclusions: The results of this study indicate that dentists practicing in Turkey lack a significant level of knowledge about syphilis. This highlights the need for further training and education programs for dentists in Turkey.

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“…Shows comparison with different studies[8,[21][22][23][24].Also, a 23% HIV-syphilis co-prevalence rate were seen in a populationbased study in HIV positive Andhra Pradesh, India[25].Bourouache M et al, reported in their study that syphilis was prevalent in 16.42% in Morocco[26].Haule A et al, reported a prevalence of syphilis in HIV-infected patients of 9.6% in Tanzania[27]. Santos AM et al, reported a prevalence of 18.4% among HIV-infected patients in Brazil[28].Khan S et al, reported a prevalence of 6.5% syphilis among the HIV-positive individuals screened for syphilis in South India between…”

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confidence: 84%

Seroprevalence of Syphilis, Human Immunodeficiency Virus and its Co-infection in Patients Attending an ICTC at a Tertiary Care Hospital in Villupuram, Tamil Nadu, India

Kavitha¹,

Deepa²,

Balapriya³

2023

NJLM

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Introduction: Human Immunodeficiency Virus (HIV) and syphilis co-infection is common and affects similar age groups. The presence of syphilis infection increases the chances of transmission of HIV. Syphilis has a negative impact on HIV infection, resulting in increasing viral loads and decreasing Cluster of Differentiation 4 (CD4) cell counts during syphilis infection. Aim: To determine the seroprevalence of syphilis, quantify HIV-Syphilis co-infection in patients attending an Integrated Counseling and Testing Centre (ICTC) centre. Materials and Methods: This cross-sectional study was conducted at the Department of Microbiology, Government Villupuram Medical College, Tamil Nadu, India, for a period of four months from March 2021 to June 2021. All consecutive adult patients attending ICTC during the study period for voluntary testing or referred from antenatal clinic or Sexually Transmitted Disease (STD) clinic were included. Patients who were on treatment or follow-up of syphilis were excluded. Pretest counselling session was given and consent was taken for HIV testing. The HIV antibody tests were performed and interpreted according to the National AIDS Control Programme (NACO) guidelines. Rapid Plasma Reagin test (RPR) screening was done. Positive cases were subjected to Treponema pallidum Haemagglutination Assay (TPHA) and Syphilis Rapid Immunochromatographic Test (RICT). The results were analysed with the data systematically entered in Microsoft Excel format and p-value was calculated by Fisher’s- exact test using epi infoTM software. Results: Among the 400 patients attending the ICTC who were included in the study, six patients had a reactive HIV test. The overall HIV positivity was 1.5% (6/400). The RPR test was positive in 7/400 patients (1.75%). Among the seven patients with RPR positivity, five patients were positive by TPHA and Syphilis RICT. Biological False Positivity (BFP) rate in RPR against TPHA was 28%. Thus the frequency of syphilis among the study population by the confirmatory test TPHA was 1.25%. Among the five confirmed cases of syphilis, four patients were males (80%) and one patient was female gender (20%). Four of the five patients were in the 28-37 year old age group (80%) and one patient was in the 38-47 year age group (20%). The frequency of syphilis was 16.67% among HIV positives (17%) and 1.02% among HIV negatives biological false positivity by RPR was observed in 29% of the cases. Conclusion: HIV and Syphilis co-infection is common and Specific Treponemal tests could contribute to reducing errors due to false positivity by non specific tests like RPR which can be used as a screening test in microbiology laboratories.

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The prevalence of syphilis in HIV-seropositive patients: a retrospective study at the regional hospital in Agadir, Morocco

Cited by 5 publications

References 39 publications

Sero-prevalence of syphilis infection among people living with HIV in Sierra Leone: a cross-sectional nationwide hospital-based study

Sero-prevalence of syphilis infection among people living with HIV in Sierra Leone: a cross-sectional nationwide hospital-based study

Syphilis and dentists: The data about knowledge and awareness of clinicians in Turkey

Seroprevalence of Syphilis, Human Immunodeficiency Virus and its Co-infection in Patients Attending an ICTC at a Tertiary Care Hospital in Villupuram, Tamil Nadu, India

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