The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency

Kang, Min Jae; Kim, Jae Hyun; Lee, Sun Hee; Lee, Young Ah; Shin, Choong Ho; Yang, Sei Won

doi:10.1507/endocrj.k11e-034

Cited by 22 publications

(25 citation statements)

References 37 publications

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“…Compared to other authors [8, 27], however, the prevalence in this study was low. Kang et al [27] found TART in 64.6% of 48 patients aged 10.6–27.1 years, who had 82.4% of 17-OHP dosages above 10 ng/mL; this percentage was higher than that found in this study in the 6 years before ultrasonography (41.7%).…”

Section: Discussioncontrasting

confidence: 98%

“…Kang et al [27] found TART in 64.6% of 48 patients aged 10.6–27.1 years, who had 82.4% of 17-OHP dosages above 10 ng/mL; this percentage was higher than that found in this study in the 6 years before ultrasonography (41.7%). Possibly, the difference occurred because our group had a better control of the treatment.…”

Section: Discussioncontrasting

confidence: 70%

“…Regarding the 17-OHP levels considered by the literature as an acceptable disease control [26, 27], the patients were divided into 2 other groups: Group 17-OHP < 10 ng/mL (G < 10) and Group 17-OHP ≥ 10 ng/mL (G ≥ 10) according to the median of this parameter in the considered period.…”

Section: Methodsmentioning

confidence: 99%

“…Mean prescribed doses of glucocorticoids were calculated for each period and converted into hydrocortisone equivalents as following: 0.75 mg dexamethasone = 5 mg prednisone = 20 mg hydrocortisone [17, 27, 28]. …”

Section: Methodsmentioning

confidence: 99%

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Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

et al. 2018

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Background: Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males. Aims: To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development. Methods: This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages. Data on prescribed glucocorticoid dose and serum levels of 17- hydroxyprogesterone (17-OHP), androstenedione (Andro), ACTH, renin, and LH were obtained from medical records. Results: Thirty-eight males were evaluated. The mean age on ultrasonography was 15.2 ± 6.7 (3–27) years. Nine patients (23.7%) had TART, 4 of them were prepubertal and the youngest was 5 years old. No association was found between TART and 21-OHD phenotype, glucocorticoid dose, or 17-OHP, ACTH, LH, renin, and inhibin B levels measured in the 6 preceding years. However, 50% of the patients who presented increased Andro 2 years prior to the evaluation had TART (p = 0.018, OR = 8.00 [95% CI: 1.42–44.92]), whereas in the normal Andro group only 16.7% had tumors. Conclusion: This study showed that TART can occur in prepubertal patients and that disease control could be a factor associated with its development. Therefore, we suggest investigating TART development early in childhood, mainly in poorly controlled 21-OHD patients.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussioncontrasting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

et al. 2018

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“…Частота ТАRТ при ВДКН зависит от когорты пациентов, метода выявления опухоли и варьирует от 0 до 94% [20], в среднем со-ставляя 20-60% [15,[21][22][23]. Основное внимание уделяют развитию ТАRТ у взрослых пациентов.…”

Section: результаты и обсуждениеunclassified

The development of ectopic testicular adrenal rest tissue (TART) in the children and adolescents presenting with congenital adrenal cortical dysfunction

Чугунов

Soldatova

Vorontsov

et al. 2015

Probl Endokrinol (Mosk)

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We have evaluated the prevalence of the ectopic testicular adrenal rest tissue (TART) among 71 patients at the age varying from 1 to 19 years and compared the visualization techniques (ultrasound examination, MRI) employed to diagnose TART. This condition was revealed in 14.1% of the patients (10/71). One of them presented with the simple virile (SV) form of the disease and 9 with the salt-wasting one. Most cases of TART (9 of the ten) were diagnosed with the help of the ultrasound technique whereas MRI allowed to determine the size of the neoplasms. The study has demonstrated the relationship between TART and 17-OH and PRA (plasma rennin activity) levels at the time of their measurement. Moreover, the relationship between the number of measurements and the PRA level during the last year has been documented. It is concluded that TART most frequently develops in the children given the poorly controlled treatment; the insufficiency of both gluco- and mineralocorticoids is a predetermining but not the sole risk factor of the condition being considered.

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Anatomy of the Testis and Staging of its Cancers: Implications for Diagnosis

Berney

Ulbright

2015

Genitourinary Pathology

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The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency

Cited by 22 publications

References 37 publications

Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

The development of ectopic testicular adrenal rest tissue (TART) in the children and adolescents presenting with congenital adrenal cortical dysfunction

Anatomy of the Testis and Staging of its Cancers: Implications for Diagnosis

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