The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages

Abstract

The prevalence of thrombophilia was higher in our study group than in the general population. Furthermore, treatment with enoxaparin might improve the rate of live births in women with or without evidence of thrombophilia, especially in women with ≥4 miscarriages.

Extensive serum biomarker analysis in the prethrombotic state of recurrent spontaneous abortion

“…(B) Histogram of customized array data. 7 differentially expressed proteins are shown by histogram in the PSRSA, NRSA and NC groups. * P < .05 vs NRSA or NC groups…”

“…In this array, each antibody was printed in four duplicates, and the locations of the serum proteins in the NC, PSRSA and NRSA groups are noted in coloured boxes. (B) Histogram of customized array data 7 . differentially expressed proteins are shown by histogram in the PSRSA, NRSA and NC groups.…”

“…Acquired PTS is comprised mainly by antiphospholipid antibody syndrome (APS) and various diseases or conditions, such as tumours and long‐term immobilization that cause blood hypercoagulability. The general prevalence of PTS in the general population is 3% ~ 8%, and in a study of women with recurrent spontaneous abortion, after excluding other causes, the prevalence of the PTS reached 78% 7 . Hereditary PTS factors affect 3% to 11% of the population 8 .…”

“…The general prevalence of PTS in the general population is 3% ~ 8%, and in a study of women with recurrent spontaneous abortion, after excluding other causes, the prevalence of the PTS reached 78%. 7 Hereditary PTS factors affect 3% to 11% of the population. 8 Mitic et al 9 reported that inherited thrombophilia was found in 36% of the study subjects.…”

Heparin Use in Pregnant Women Diagnosed With Thrombophilia: Obstetric Outcomes

“…Thus, despite several conflicting outcomes found in the literature, the current data support the use of heparin by pregnant patients with adverse perinatal outcome and history of thrombophilia. Assumingly, the anticoagulant properties of heparin help mitigating thrombosis in placental microvasculature and present anti-inflammatory action resulting from adhesion protein blockage, from trophoblast differentiation promotion and from reduced binding between antiphospholipid autoantibodies and trophoblastic cells [8,[14][15][16][17][18]. According to a recent study focused on assessing pregnancy progression rate in women with acquired thrombophilia, the early-onset of heparin use has increased ongoing pregnancy rates (81.2% vs. 60.9%, P=0.040), although it did not reduce late complications [19].…”