The prevalence of Toxoplasma antibody in patients with various ocular diseases in central Japan

Goto, Kaori; Kurita, Masayuki; Masuhara, Nami; Iijima, Yasuhito; Saeki, Kozo; Ohno, Shigeaki

doi:10.1007/bf00184857

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…HTLV-I seroprevalences of 35.4-44.8% were found in patients with uveitis of unknown etiology in Southwestern Japan, much higher than HTLV-I prevalence in the local population (Mochizuki et al, 1992). In studies of other areas lower seropositivity was found (Goto et al, 1994;Pinheiro et al, 1996;Yamamoto et al, 1999).…”

Section: Uveitis Arthritis and Other Autoimmune Diseasesmentioning

confidence: 97%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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Section: Uveitis Arthritis and Other Autoimmune Diseasesmentioning

confidence: 97%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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Clinical characteristics and computed tomography findings of pulmonary toxoplasmosis after hematopoietic stem cell transplantation

et al. 2016

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The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function. In our institution, we identified nine cases of toxoplasmosis, representing incidences of 2.2 and 19.6 % among all HSCT recipients and seropositive HSCT recipients, respectively. Of the patients with toxoplasmosis, six had pulmonary toxoplasmosis. Chest computed tomography (CT) findings revealed centrilobular, patchy ground-glass opacities (n = 3), diffuse ground-glass opacities (n = 2), ground-glass opacities with septal thickening (n = 1), and marked pleural effusion (n = 1). All cases died, except for one with suspected pulmonary toxoplasmosis who was diagnosed by a polymerase chain reaction assay 2 days after the onset of symptoms. In pulmonary toxoplasmosis, CT findings are non-specific and may mimic pulmonary congestion, atypical pneumonia, viral pneumonitis, and bronchopneumonia. Early diagnosis and treatment is crucial for overcoming this serious infectious complication. Pulmonary toxoplasmosis should be considered during differential diagnosis in a recipient with otherwise unexplained signs of infection and CT findings with ground-glass opacities, regardless of the distribution.

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An age-adjusted seroprevalence study of Toxoplasma antibody in a Malaysian ophthalmology unit

Singh

Khang

Andiappan

et al. 2012

Transactions of the Royal Society of Tropical Medicine and Hygi

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Toxoplasma gondii is a public health risk in developing countries, especially those located in the tropics. Widespread infection may inflict a substantial burden on state resources, as patients can develop severe neurological defects and ocular diseases that result in lifelong loss of economic independence. We tested sera for IgG antibody from 493 eye patients in Malaysia. Overall age-adjusted seroprevalence was estimated to be 25% (95% CI: [21%, 29%]). We found approximately equal age-adjusted seroprevalence in Chinese (31%; 95% CI: [25%, 38%]) and Malays (29%; 95% CI: [21%, 36%]), followed by Indians (19%; 95% CI: [13%, 25%]). A logistic regression of the odds for T. gondii seroprevalence against age, gender, ethnicity and the occurrence of six types of ocular diseases showed that only age and ethnicity were significant predictors. The odds for T. gondii seroprevalence were 2.7 (95% CI for OR: [1.9, 4.0]) times higher for a patient twice as old as the other, with ethnicity held constant. In Malays, we estimated the odds for T. gondii seroprevalence to be 2.9 (95% CI for OR: [1.8, 4.5]) times higher compared to non-Malays, with age held constant. Previous studies of T. gondii seroprevalence in Malaysia did not explicitly adjust for age, rendering comparisons difficult. Our study highlights the need to adopt a more rigorous epidemiological approach in monitoring T. gondii seroprevalence in Malaysia.

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The prevalence of Toxoplasma antibody in patients with various ocular diseases in central Japan

Abstract: This result suggests that Toxoplasma infection could play some role in the development of a type of macular degenerative lesion.

Cited by 5 publications

References 22 publications

Global epidemiology of HTLV-I infection and associated diseases

Global epidemiology of HTLV-I infection and associated diseases

Clinical characteristics and computed tomography findings of pulmonary toxoplasmosis after hematopoietic stem cell transplantation

An age-adjusted seroprevalence study of Toxoplasma antibody in a Malaysian ophthalmology unit

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