The preventative effect of of Ro5-4864 (peripheral benzodiazepine receptor agonist) on spinal epidural fibrosis after laminectomy in a rat model

Keskin, Emrah; Can, Emine Yılmaz; Aydın, Hasan Ali; Işık, Emre; Özgen, Utku; Şimşek, Kenan; Cengil, Osman; Başar, Cansu; Kalaycı, Murat

doi:10.1080/01616412.2021.1949689

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…especially after microdiscectomy operation, epidural fibrosis rates and methods to reduce these numbers can be found in a large number of articles for example, in the experimental study conducted by Keskin et al [21] in rats, it was noticed that the use of berberine in vivo significantly reduced epidural fibrosis. Similarly, Dayanır et al [22] addressed the same issue through ozone, while many different research teams have studied the effects of systemic or local use of different molecules and pharmaceutical agents on epidural fibrosis [23,24]. In our series, when comparing flavum-preserving surgery with standard surgery, no comparison has been made radiologically regarding the development of epidural fibrosis.…”

Section: Discussionmentioning

confidence: 89%

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

ALPERGİN,

ZAİMOĞLU,

ÖZPİŞKİN

et al. 2024

Pam Tıp Derg

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Objectives: The aim of this study is to evaluate the use of flavum-preserving surgeries in lumbar disc herniation surgery, compare their clinical outcomes with standard microdiscectomy techniques, and demonstrate the transflaval microdiscectomy technique. Material and Methods: Between 2020 and 2023, a total of 48 patients who underwent transflaval microdiscectomy and 48 patients who underwent standard microdiscectomy at a single center were included in the study. Epidemiologic characteristics of the groups were described, and preoperative and postoperative visual analoge scale scores for leg pain (LPVAS) and back pain (BPVAS) were retrospectively analyzed. Results: There is no significant difference between the groups in preoperative mean LPVAS scores (p=0,474) and there is no significant difference between the groups in postoperative mean LPVAS scores (p=0,598). There is no significant difference between the groups in preoperative mean BPVAS scores (p=0,608). However there is a significant difference between the groups in postoperative mean BPVAS scores (p

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Section: Discussionmentioning

confidence: 89%

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

ALPERGİN,

ZAİMOĞLU,

ÖZPİŞKİN

et al. 2024

Pam Tıp Derg

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“…TSPO can also effectively bind with different ligands as a receptors, endogenous ligands include diazepam binding inhibitor (DBI), porphyrins, etc., (Kołodziejczyk, 2015). Exogenous ligands including 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3isoquinolinecarboxamide (PKlll95) and 4 -chlorodiazepam (R05-4864) (Keskin et al, 2021;Yusuying et al, 2021) can bind to TSPO receptor can modulate its diverse physiological function, such as modulation of neurosteroid synthesis, etc. TSPO is an important component of the steroid synthesis (Selvaraj et al, 2015).…”

Section: Translocation Protein 18 Kdamentioning

confidence: 99%

Research Progress on the Role of Microglia Membrane Proteins or Receptors in Neuroinflammation and Degeneration

Zhao

Ren

et al. 2022

Front. Cell. Neurosci.

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Microglia are intrinsic immune cells of the central nervous system and play a dual role (pro-inflammatory and anti-inflammatory) in the homeostasis of the nervous system. Neuroinflammation mediated by microglia serves as an important stage of ischemic hypoxic brain injury, cerebral hemorrhage disease, neurodegeneration and neurotumor of the nervous system and is present through the whole course of these diseases. Microglial membrane protein or receptor is the basis of mediating microglia to play the inflammatory role and they have been found to be upregulated by recognizing associated ligands or sensing changes in the nervous system microenvironment. They can then allosterically activate the downstream signal transduction and produce a series of complex cascade reactions that can activate microglia, promote microglia chemotactic migration and stimulate the release of proinflammatory factor such as TNF-α, IL-β to effectively damage the nervous system and cause apoptosis of neurons. In this paper, several representative membrane proteins or receptors present on the surface of microglia are systematically reviewed and information about their structures, functions and specific roles in one or more neurological diseases. And on this basis, some prospects for the treatment of novel coronavirus neurological complications are presented.

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Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects

et al. 2022

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The preventative effect of of Ro5-4864 (peripheral benzodiazepine receptor agonist) on spinal epidural fibrosis after laminectomy in a rat model

Cited by 5 publications

References 44 publications

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

Research Progress on the Role of Microglia Membrane Proteins or Receptors in Neuroinflammation and Degeneration

Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects

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