The Prevention of Acth-Induced Sodium Retention by the Use of Potassium Salts: A Quantitative Study

Liddle, Grant W.; Bennett, Leslie L.; Forsham, Peter H.

doi:10.1172/jci102846

Cited by 25 publications

(7 citation statements)

References 7 publications

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“…In spite of the slight, but persistent, loss of sodium in the experiments where a bladder catheter was used, the natriuresis which followed an intraruminal load of K salts was similar to that observed in the earlier experiments without bladder catheterization. A similar effect has been reported by Berliner, Kennedy & Orloff (1951) in dogs; by Liddle, Bennett & Forsham (1953) in man, and by Anderson & Pickering (1962) in cattle. Berliner et al (1951) postulated a competition between hydrogen and potassium ions for some component of the ion exchange mechanism by which both are secreted in the distal tubule.…”

Section: Discussionsupporting

confidence: 86%

“…This explanation appears to require maximum sodium loss to be coincident with maximum potassium loss which was not observed in our experiments. Liddle et al (1953) added to the above explanation the possibility of displacement of body Na+ by K+ as a mechanism producing the natriuretic effect of potassium salts. It is possible that Na+ could be displaced by K+ from the rumen as has been suggested by Dobson, Scott & Bruce (1966) to explain a loss of sodium which they observed in sheep subjected to a change in diet.…”

Section: Discussionmentioning

confidence: 99%

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Renal excretion of potassium in the sheep

Dewhurst¹,

Harrison²,

Keynes³

1968

The Journal of Physiology

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SUMMARY1. Observations were made on the daily intake and excretion of potassium and sodium in sheep housed in metabolism cages and fed once daily.2. The diet of chaffed hay and crushed oats provided 400-600 m-moles K and 50-60 m-moles Na daily. About 90 % of the K was excreted in the urine, and over 90 % of the Na was found in the faeces.3. In two groups of three experiments on each of three sheep, the urinary responses to intra-ruminal dosing just before feeding of (i) 1 1. distilled water, (ii) 1 1. 0-25 N-KCl, and (iii) 1 1. 0 125 N-NaCl, were studied. In the first group, urine was collected via the urine/faeces separator of the metabolism cage, whereas for part of the experiments in the second group it was collected by an indwelling bladder catheter.4. In a third group of experiments with the same sheep, the effects on urinary excretion of K and Na of intra-ruminal dosing with (i) 1 1. distilled water, (ii) 1 1. 0-25 N-K acetate, and (iii) 11. 0-25 N-Na acetate were investigated. During part of these experiments urine was again collected via an indwelling bladder catheter. With chloride, 82 % of the additional potassium was excreted in urine in the 24 hr after dosing, but with acetate only 65 %. For sodium, the corresponding figures were 12-40 % with chloride and 43 % with acetate.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Renal excretion of potassium in the sheep

Dewhurst¹,

Harrison²,

Keynes³

1968

The Journal of Physiology

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“…Anderson & Pickering (1962) noted a rise in Na excretion in response to intravenous K infusion in the cow. A similar effect has been reported in response to intravenous K infusion in the dog (Berliner, Kennedy & Orloff, 1951) and to oral K in man (Liddle, Bennett & Forsham, 1953). In our experiments increased K excretion induced by K administration per fistulam was also accompanied by Na excretion.…”

Section: Psupporting

confidence: 91%

Proceedings of the Physiological Society, 15 July 1966; Cambridge Meeting: Demonstrations

1966

The Journal of Physiology

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“…Laragh and Capeci (26) also observed no appreciable change in Na excretion during KCl administration to dogs. These results may reflect a difference in the response of dog and man to K administration, since several observers (2,3,27) have reported a natriuresis during K administration to human subj ects.…”

Section: Discussionmentioning

confidence: 89%

The Effects of Alterations of Plasma Sodium and Potassium Concentration on Aldosterone Secretion*

Davis¹,

Urquhart²,

Higgins³

1963

J. Clin. Invest.

198

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Mlany studies have been conducted on the relation of electrolytes to the control of aldosterone secretion. It was reported by Luetscher and Axelrad (1) and confirmed by others (2-4) that a low Na intake augments the rate of urinary aldosterone excretion in normal man. Also, it has been clearly established that chronic Na depletion increases aldosterone secretion in sheep (5, 6), dogs (7,8), and rats (9). On the other hand, the relation of K intake to aldosterone production has never been settled. Several investigators (2, 3, 10) have reported that K loading leads to hyperaldosteronuria; the response was observed only in the presence of a low Na intake or was greater with a reduced intake of salt. In contrast, Hernando and associates (4) failed to find an increase in urinary aldosterone output during K loading even in the presence of a superimposed low Na intake.The influence of hyperkalemia and of hyponatremia has also been a controversial issue. Laragh and Stoerk (10) were first to report that a high plasma K concentration increases aldosterone secretion. Later, Moran. Rosenberg, and Zimmerman (11) presented data which suggested that intravenous infusion of KCl into intact dogs increased aldosterone secretion, but Gann, Cruz, Casper. and Bartter (12) were unable to confirm this finding. Denton, Goding, and Wright (5) provided evidence that a low Na and high K concentration in plasma perfusing an isolated adrenal stimulates aldosterone production in sheep; also, some of their more recent findings (6) suggest that this directional alteration in either ion alone augments aldosterone secretion. * Preliminary report was made at the meeting of the Federation of American Societies for Experimental Biology, April, 1962. The present observations were undertaken to determine the separate influences of 1) a decrease in plasma Na concentration and 2) an elevation in the plasma K level on aldosterone secretion. As emphasized previously (13,14), it is frequently important for acute studies in laparotomized dogs to be conducted in hypophysectomized animals because of the influence of ACTH which is present in increased amounts in stressed animals. Studies were first conducted on the effects of intravenous infusion of a K salt on aldosterone secretion in hypophysectomized dogs. Subsequently, the influence of acute bilateral nephrectomy on the hypersecretion of aldosterone induced by hyperkalemia was determined. The possible direct effect of either a low plasma Na or a high plasma K concentration on the adrenal cortex was examined by producing local alterations in these ions in arterial blood perfusing isolated adrenals. Finally, the physiological significance of alterations in K intake on aldosterone production was investigated by studying the response to a high K intake. The plasma K concentration and the rate of urinary aldosterone excretion were observed for several hours following the daily meal during which a progressive elevation in the plasma K concentration occurred during the high K diet. MATERIALS AND METHODSIittra...

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The Prevention of Acth-Induced Sodium Retention by the Use of Potassium Salts: A Quantitative Study

Cited by 25 publications

References 7 publications

Renal excretion of potassium in the sheep

Renal excretion of potassium in the sheep

Proceedings of the Physiological Society, 15 July 1966; Cambridge Meeting: Demonstrations

The Effects of Alterations of Plasma Sodium and Potassium Concentration on Aldosterone Secretion*

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