The Prevention of Gestational Diabetes

Abstract

The negative impact of the gestational diabetes on the maternal and fetal health is well known and this impact is closely related to gestational age at which the diagnosis is done. Therefore, the use of therapeutic options able to prevent or delay the gestational diabetes occurrence has a positive impact on maternal and neonatal outcomes.Physical activity and dietary advice represent the first choice and they are the most studied as well. They represent a non-pharmacological option and have a positive impact on insulin resistance although they do not seem to prevent the gestational diabetes onset.The preconceptional use of metformin in women with polycystic ovary syndrome protects the pancreatic beta cell reserve preventing or delaying the occurrence of gestational diabetes. However, there are also doubts on the drug safety in pregnancy since it completely crosses the placenta.From this point of view, the inositol could represent an excellent alternative.Its role as insulin sensitizing agent is well documented on improving both the hormonal and reproductive parameters. However, the studies on its preconceptional use in preventing gestational diabetes are too limited though the first results are extremely encouraging.

Multipollutant, longitudinal analysis of the association between urinary tungsten and incident diabetes in a rural population

“…For example, chromium, another group six transition metal with a high melting point, is involved with the metabolism of glucose and insulin. 53,54 Furthermore, there could be sex-differences underlying the mechanisms relating urinary W to diabetes. For example, one study observed that the effect of W on bone homeostasis in mice was sex-dependent.…”

Evaluation of the Content of Micro- and Macroelements in Raspberries Depending on the Species, Cultivar Variety, and Geographical Environment

“…Studies on Cr deficiency indicate that chromium is an essential element involved in the action of insulin [67]. There is increasing evidence that Cr supplementation, especially in higher doses and in the form of free chromium, may improve insulin and glucose sensitivity in type 1 and 2 diabetes [70,71]. The 'Bristol' variety of black raspberry seems to be important in the prevention and treatment of metabolic diseases due to the high content of chromium, zinc and manganese, the deficiency of which is associated, among others, with the development of diabetes.…”

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“…Shilajit contains many trace elements including, chromium, potassium, magnesium, zinc, copper, iron, and many others (Mishra et al, 2019). Shilajit contains chromium, which is very important in carbohydrate and lipid metabolism and is recommended to be taken by diabetic patients; it increases insulin binding to its receptors; thus, it increases insulin sensitivity (Anderson, 2000). Taking a mixture of 12 herbs twice a day for 13 days in 10 diabetic patients, including Shilajit, significantly reduced the accumulative hemoglobin HbA1C (Pal & Shrivastav, 2020).…”