The Prevention of Neurogenetic Disease

Rosenberg, Roger N.; Iannaccone, Susan T.

doi:10.1001/archneur.1995.00540280038016

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…particular, MMP-9 and MMP-2 are the key enzymes involved in the degradation of type IV collagen and the ECM (7), and are mainly associated with tumor invasion, degradation of the blood-brain barrier, neuro-degenerative processes, and angiogenesis in gliomas (8,9). MMP-9 and MMP-2 have structural and catalytic similarities.…”

Section: Isothiocyanates Inhibit the Invasion And Migration Of C6 Glimentioning

confidence: 99%

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

et al. 2015

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Isothiocyanates (ITCs) derived from cruciferous vegetables, including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane (SFN), exhibit preventative effects against various types of cancers. Yet, the inhibitory effects of ITCs on C6 glioma cell invasion and migration have not been reported. Thus, we aimed to analyze ITC-regulated MMP-9 activation, a crucial enzyme of cancer metastasis that degrades the extracellular matrix, in C6 glioma cells to investigate the inhibitory effects on cancer invasion and migration by ITCs. In the present study, we found that ITCs specifically suppressed PMA-induced MMP-9 secretion and protein expression. The inhibitory effects of ITCs on PMA-induced MMP-9 expression were found to be associated with the inhibition of MMP-9 transcription levels through suppression of nuclear translocation of NF-κB and activator protein-1 (AP-1). It was also confirmed that ITCs decreased MMP-9-mediated signaling such as FAK and JNK, whereas they had no effect on the phosphorylation of ERK and p38. Moreover, wound-healing and Τranswell invasion assays showed that ITCs inhibited the migration and invasion of C6 glioma cells. These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK/JNK-mediated MMP-9 expression.

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Section: Isothiocyanates Inhibit the Invasion And Migration Of C6 Glimentioning

confidence: 99%

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

et al. 2015

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“…For example, the mean age of those at risk ranged from 26.2 years in the study by Giordani et al (1995), to 41.1 years of age in the study by Foroud et al (1995), with the mean ages of most participants being in the early 30's (e.g. Hahn-Barma et al, 1998;Lundervold & Reinvang, 1995;Rosenberg et al, 1995;Strauss & Brandt, 1990).…”

Section: Limitationsmentioning

confidence: 85%

“…There is typically a decline in Performance IQ in HD (Butters et al, 1978;Wilson & Garron, 1979). Similarly, Rosenberg et al (1995) found that the HD-group performed below standardised norms on tests of concentration, which Rosenberg and colleagues put down to stress, related to the testing situation. The results of the present study support these findings.…”

Section: Control Groups In Previous Studiesmentioning

confidence: 93%

“…HD is the first neuropsychiatric disease for which predictive testing programmes was made available (Farmer & Owen, 1996). As such it has become the model for other neurogenetic predictive testing programmes (Rosenberg & Iannaccone, 1995). All international programmes, including South Africa's, follow the guidelines set out for molecular genetics testing recommended by the International Huntington Association, and revised by the World Federation of Neurology Research Group on Huntington's Chorea (see Benjamin et al, 1994 and Guidelines for the molecular genetics predictive test in Huntington's disease, 1994aHuntington's disease, , 1994b.…”

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confidence: 99%

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Predictive Testing for Huntington's Disease: How Does it Impact on Cognitive Performance?

Lucas

Turnbull

Berk

et al. 2002

South African Journal of Psychology

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The discovery of a polymorphic DNA marker for Huntington's Disease (HD) in 1983, and the specific gene responsible in 1993, led to predictive testing programmes out of which came research into whether or not cognitive impairment was present presymptomatically in those at risk for HD. The results of these studies have been conflicting and inconclusive. Methodoiogical limitations have probably contributed to the differing findings. The present study attempted to expand upon previous studies by analysing the data in a more comprehensive manner, and with additional control conditions. In this study, 26 individuals, at risk but presymptomatic, for HD were recruited from the Johannesburg Predictive Testing Programme and administered a battery of psychological tests prior to molecular analysis. Of this HD group, 11 were subsequently positive for the gene (the HD+ group) and 15 were negative (HD- group). A carefully chosen control group, (matched for age, sex, and education - Control Group 1) and a group of individuals experiencing a life threatening medical illness (without CNS involvement - Control Group 2) were administered the same battery of psychological tests. Four-way Analysis of Variance between the HD+, HD-, and Control groups was conducted to detect specific differences between the groups. The results indicated that the HD+ group showed mild impairment for declarative memory function. However, it would appear that undergoing the psychological evaluation itself impacted upon the test performance of both the HD+ and HD- groups.

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“…More modern studies of diatheses have focused on genetic vulnerabilities that predispose individuals to disease (Falconer, 1965). The discoveries of genetic markers for some types of breast cancer (Newman & Liu, 1998), Parkinson's disease (Gasser et al, 1998) and for Huntington's disease and neurofibromatosis (Rosenberg & Iannaccone, 1995) are examples of this trend. The presence of a genetic marker does not necessarily mean there is an underlying biological predisposition, but it is one of the closest measurements, other than specific gene typing, currently available for assessing genetic predisposition.…”

Section: History Of the Modelmentioning

confidence: 99%

Personality and pain: Summary and future perspectives.

Clark¹,

Weisberg²

2000

Personality Characteristics of Patients With Pain.

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The preceding chapters of this text review the history of personality investigation in chronic pain; personality measures currently in use in the chronic pain population; and promising new instruments to help guide clinicians toward early, accurate diagnosis of personality traits and disorders. A major goal of early, accurate diagnosis is providing clinicians with increased knowledge about how patients' personality function is or is not related to their pain, thereby helping to optimize treatment outcomes. Ultimately, understanding an individual's personality characteristics or disorders should increase early detection of those at risk for developing chronic, debilitating pain, allowing intervention on as many dimensions as possible during the acute and subacute phases of pain as a way to prevent the progression to chronicity.In this chapter, we summarize the advantages of personality assessment and some of the best instruments to use, including a recently developed method of assessing personality pathology from a trait dimensional perspective-the Schedule for Nonadaptive and Adaptive Personality (SNAP). We also present a model of personality disorders in chronic pain recently introduced in the literature-the diathesis-stress model (Weisberg & Keefe, 1997). This model provides a testable hypothesis for the observation that many chronic pain patients have comorbid personality disorders, the presence of which they, their families, and their friends deny before the onset of pain. The Diathesis-Stress ModelA diathesis-stress model of personality disorders in chronic pain has been proposed (Weisberg & Keefe, 1997) to explain the discrepancy between the rates of those disorders in the general population and in the chronic pain population. The model posits that personality disorders develop as an interaction between underlying personality predispositions (or diatheses) and the extreme stress of pain and its physical, psychological, and social consequences. In this model, disorder is a consequence of acute and subacute pain, and it also can perpetuate chronic, disabling pain. The summary here provides a theoretical rationale for such a model to be tested for its heuristic and predictive value, and it provides information to help clinicians assess personality function in the context of long-standing traits and current stressors.It is well-established that personality disorders are highly prevalent in patients with chronic pain (Gatchel, Garofalo, Ellis,

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The Prevention of Neurogenetic Disease

Cited by 9 publications

References 46 publications

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression

Predictive Testing for Huntington's Disease: How Does it Impact on Cognitive Performance?

Personality and pain: Summary and future perspectives.

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