The Prevention of Peritoneal Adhesions by Papain

Ochsner, Alton; Storck, Ambrose H.

doi:10.1097/00000658-193610440-00022

Cited by 15 publications

(2 citation statements)

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“…As a popular folk remedy, papain was used to reduce pain, inflammation, infection, swelling, diarrhea, and allergies, in addition to improving digestion. It is also known for its wound healing properties [12], antibacterial activity [13], and exhibits inhibitory effects on platelet activation [14], monocyte-platelet aggregate formation [15], strongyloidiasis [16], atherosclerosis [17] and peritoneal adhesion [18]. However, its effect on obesity has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation

Kang

Cominguez

et al. 2021

IJMS

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Papain is a proteolytic enzyme present in the leaves, fruits, roots, and latex of the Carica papaya (papaya) plant. Although it exhibits a wide range of activities, there are no reports on the anti-obesity effects of papain. This study examined the anti-obesity effect and obesity-involved anti-inflammatory mechanism of papain in in vivo and in vitro models using high-fat diet (HFD)-induced obese mice and 3T3-L1 preadipocytes. Oral administration of papain reduced HFD-induced weight of the body, liver, and adipose tissues of mice. Papain also reduced hepatic lipid accumulation and adipocyte size. Moreover, serum total cholesterol and triglyceride levels were markedly reduced in papain-treated mice. In addition, papain inhibited the differentiation of preadipocytes and oil accumulation in 3T3-L1 preadipocytes and rat primary preadipocytes. Mechanistically, papain significantly downregulated the protein levels of key adipogenesis regulators and reversed the expression of pro-inflammatory cytokines and adipokines in HFD-induced obese mice and 3T3-L1 preadipocytes. Papain also markedly enhanced activation of the AMP-activated protein kinase pathway in both models. Collectively, these results suggest that papain exerts anti-obesity effects in HFD-induced mice and 3T3-L1 preadipocytes by regulating levels of adipogenic factors involved in lipid metabolism and inflammation; thus, it could be useful in the prevention and treatment of obesity.

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Section: Introductionmentioning

confidence: 99%

Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation

Kang

Cominguez

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…4 In 37 of these cases subsequent operations were performed, thereby allowing observation as to the effectiveness of the solution of papain which had been instilled at a previous operation. In this series it was used prophylactically, or to prevent the reforma¬ tion of adhesions, in 231 cases.…”

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confidence: 99%