The preventive effect of cellulose from Pleurotus eryngii on fatty liver of hyperlipidemic rats

Huang, Jia Fu; Ou, Yi Xin; Li, Xiu Min; Lin, Zhiyong; Leng, Bo; Xue, Yu; Su, Yi; Pan, Yi

doi:10.4066/biomedicalresearch.29-17-2500

Cited by 1 publication

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the NC group, livers in the HF group were significantly larger, and showed yellowish-brown, blunt edges and irregular adipose tissue deposition under capsules with greasy sections, and the HF group also displayed severe steatosis, enlarged hepatocytes with many large lipid droplets in the endochylema, a narrowed hepatic sinus resulting from compression, and disordered hepatic cords. All of the above symptoms were consistent with studies performed by Xing and Huang et al (Hsieh et al, 2012;Huang et al, 2016;Xing et al, 2004). Following 4 weeks of treatment with P. eryngii chitin, serum ALT and AST levels were significantly reduced, hepatic SOD enzymatic activity was significantly improved, and the liver index and MDA content in the liver were decreased.…”

Section: Discussionsupporting

confidence: 91%

“…Chitin in nature is a rare basic polysaccharide with a positive charge, typically found in the shells of insects and aquatic crustaceans, fungal cell walls, and algae; it is nontoxic, hydrophilic, bio-soluble, biodegradable, and has antibacterial characteristics (Jiang, 1996). Chitin has been reported to reduce caloric intake and accumulation of triglycerides in the liver, and lower serum lipid levels (Huang et al, 2016;Neyrinck et al, 2011;Zacour et al, 1992). Chitin exerts lipids-modifying effects mainly through regulation of cholesterol biosynthesis, metabolism, and efflux (Yang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic effects of chitin from Pleurotus eryngii on high-fat diet induced obesity in rats

Huang¹,

Wu²,

Lin³

et al. 2020

Acta Sci Pol Technol Aliment

View full text Add to dashboard Cite

Background. Recent shifts in lifestyles and diets have caused the incidence of obesity to increase rapidly, resulting in a serious threat to modern human health. There is a growing interest the use of plant or fungi derived supplements as a safe and effective means to treat obesity. In recent times, edible-medicinal fungi have garnered attention as therapeutics owing to their biocompatibility and effectiveness. Attempts to determine the therapeutic effects of these fungi have become a prime focus in drug discovery programs. Therefore, this study aimed to determine the anti-obesity effects of P. eryngii chitin in rats with obesity induced by administration of a high fat diet. Material and methods. To investigate the therapeutic effects of chitin from Pleurotus eryngii on high fat diet-induce obesity, we treated obese rats with different concentrations of chitin from P. eryngii for 4 weeks, using Lipitor as positive control. The living condition, food intake, body weight, perirenal adipose tissue, periepididymal adipose tissue, adipose tissue coefficient, serum lipid levels, including total cholesterol (TC), total glyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were measured, and levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), themalonaldehyde (MDA), and superoxide dismutase (SOD) activity in liver were determined. The rats were also monitored for pathological changes in the liver and aorta. Results. These studies indicated that administration of chitin from P. eryngii could significantly decrease obese rat food utilization rates and accumulation of adipose tissue in the body, thus preventing development of increased body weight. The treatment also significantly reduced serum lipid levels, including levels of TC, TG and LDL-C. Treatment with P. eryngii-derived chitin also enhanced ALT and AST enzymatic activity, enhanced SOD enzymatic activity, and reduced the MDA content of the liver, as well as significantly reducing the liver index and alleviating liver steatosis and aortic atherosclerosis resulting from obesity. Conclusion. In conclusion, chitin from P. eryngii had therapeutic effects on hyperlipidemia, fatty liver, and aortic atherosclerosis resulting from obesity in rats.

show abstract

Section: Discussionsupporting

confidence: 91%