The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model

Akçan, Alper; Sözüer, Erdoğan; Küçük, Can; Yılmaz, Namık; Denız, Kemal

doi:10.1016/j.surg.2008.04.012

Cited by 8 publications

(7 citation statements)

References 54 publications

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“…Neither one of the present authors (MD) nor others (27)(28)(29)(30) have been able to identify molecular biologic evidence of an impact of modified hyaluronic acid and carboxymethylcellulose on mRNA expression of tissue plasminogen activator (28), collagen I, transforming growth factor beta (28), matrix metalloproteinase I (28), tissue plasminogen activator activity (28), vascular endothelial growth factor expression (29), or polymorphonuclear neutrophil (PMN) phagocytosis. Similarly, there does not appear to be a change in the rate of PMN apoptosis/necrosis, production of cytokines (tumor necrosis factor-alpha, interleukin-1a, interleukin-6, interleukin-8, interleukin-1 receptor antagonist), or PMN elastase in response to the use of this product (30).…”

Section: Discussionmentioning

confidence: 93%

Gynecologic use of Sepraspray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study

Fossum

Silverberg

Miller³

et al. 2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 93%

Gynecologic use of Sepraspray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study

Fossum

Silverberg

Miller³

et al. 2011

Fertility and Sterility

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“…The intra-abdominal administration of antiadhesive barriers, such as a bioresorbable membrane consisting of sodium hyaluronate, polyethylene glycol, fibrin sealant, oxidized regenerated cellulose, expanded polytetrafluoroethylene, and carboxymethylcellulose, may reduce postoperative adhesions, as demonstrated by some animal models and clinical studies [1, 4–6]. Some of these agents have been shown to reduce the number and quality of adhesions, but none are universally effective and their modes of action are poorly understood [8, 17]. …”

Section: Discussionmentioning

confidence: 99%

The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats: Experimental Study

Başbuğ

Bülbüller

Camcı

et al. 2011

Gastroenterology Research and Practice

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Aims. This study determined the effects of a single dose of bevacizumab, an antiangiogenic recombinant monoclonal antibody that specifically targets vascular endothelial growth factor (VEGF), on adhesion formation in the rat cecal abrasion model. Methodology. Thirty female Wistar albino rats (200–224 g) were divided into three groups. All rats underwent laparotomy at which time cecal wall abrasion and abdominal wall injuries were induced. Group I (control) underwent only the abrasion procedure; Groups II and III received saline or bevacizumab intraperitoneally, respectively, following the abrasion. The rats were killed on postoperative day 7, and the severity of adhesions was evaluated, together with histopathological fibrosis parameters and immunohistochemical staining to identify the VEGF receptor. Results. The mean adhesion severity score in Groups I–III was 2.5 ± 0.52, 2.4 ± 0.69, and 0.7 ± 0.82, respectively; the score in Group III was significantly lower than that in Groups I (P < 0.001) and II (P < 0.001). In the histopathological evaluation, the mean fibrosis score in Group III was significantly lower that the scores in Groups I (P < 0.001) and II (P < 0.001). VEGF staining of the adhesion areas in Group III was significantly lower than that in Groups I (P < 0.001) and II (P < 0.001). Conclusion. Bevacizumab decreases adhesion formation following laparotomy in rats by blocking VEGF receptor occupancy.

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“…Prevention of fibrin formation with pharmacological agents, such as corticosteroids, heparin or tissue plasminogen activator, sodium hyaluronate, urokinase, application of anti-adhesive film modified chitosan (Murata et al, 2006;Singer et al, 1996b); 3. Reduction of the contact between organs and intraabdominal contents by using biodegradable barriers such as sodium hyaluronate (SHA), seprafilm, seprafilm antiadhesion film (Akyildiz et al, 2008); 4. Use of various biologically active substances such as intraoperative use of biological polysaccharide flushing liquid.…”

Section: Introductionmentioning

confidence: 99%

“…Some of them are only effective in the short term. Some have no impact on inflammation activity, while others have severe detrimental impacts (Akyildiz et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine for intestinal adhesion: A meta-analysis of randomized controlled trials

Su¹,

Li²,

Yang³

et al. 2017

J. Med. Plants Res.

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For many years, traditional Chinese medicine (TCM) has been used to treat patients with intestinal adhesion. However, no meta-analysis has been previously conducted to investigate the benefits of TCM therapy in patients with such disorder. This paper aims to summarize the beneficial effects of applying TCM as an adjuvant in patients with intestinal adhesion through conducting a meta-analysis. Until October 2016, seven databases have been retrieved to conduct randomized controlled trials (RCTs) and investigate the effects of applying TCM as an adjuvant treatment in patients with the mentioned disorder. The risk of bias has been assessed according to Cochrane Handbook guidelines. 24 of the 169 potentially relevant trials met the inclusion criteria. However, their methodological qualities were low. The application of TCM as an adjuvant was associated with a significantly lower incidence of intestinal adhesion, as well as higher total effective rate. Compared with the controls as adjuvant treatment, TCM therapy promoted incision healing and reduced the recovery time of borborygmus, anal exhaust time and first defecation time as well as gastrointestinal decompression duration. However, the pooled data for the studies showed there was no difference in blood plasma fibrinogen (FIB). This meta-analysis suggests that TCM therapy appears to cause additional beneficial effects in patients with intestinal adhesion. However, available studies are not adequate to draw a conclusion on the efficacy of TCM due to the methodological flaws of the included trials. Hopefully this work will provide useful experience for further studies; better designed trials are needed to confirm the findings in this study.

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The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model

Cited by 8 publications

References 54 publications

Gynecologic use of Sepraspray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study

Gynecologic use of Sepraspray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study

The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats: Experimental Study

Traditional Chinese medicine for intestinal adhesion: A meta-analysis of randomized controlled trials

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