The Preventive Effect of Vitamin C on Styrene-Induced Toxicity in Rat Liver and Kidney

Ahmadizadeh, Massumeh; Abdolkany, Ebrahim; Afravy, Maryam

doi:10.5812/jjhs.26849v2

Cited by 7 publications

(8 citation statements)

References 31 publications

(38 reference statements)

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“…[22] In previous studies, the toxic effect of styrene on the liver of animal models has been reported. [23] Some of the styrene hepatotoxic effects are related to its transformation by hepatic enzymes. Styrene is metabolized in the liver and transformed into styrene oxide that is a toxic and potentially carcinogenic metabolite.…”

Section: Discussionmentioning

confidence: 99%

Volatile organic compounds as a preventive health challenge in the petrochemical industries

2019

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Background:The aim of this study was to assess the effects of long-term exposure to VOCs on employees’ clinical parameters in one of the main petroleum centers in Iran.Methods:In this case-control study, 80 operational and administrative employees with 8–15 years of work experience were considered as the case and control groups. Liver function was evaluated by measuring serum alanine transaminase (ALT) activity and lipid profile was measured. Gas chromatography-mass spectrometry (GC-MS) was used to analyze the VOCs levels at the workplace.Results:There were increased levels of serum ALT (P = 0.003), triglycerides (P = 0.015), total cholesterol (P = 0.003), and LDL-C (P = 0.010) among the operational staffs compared to the administrative staffs. Assessment of the relationship between worksite pollutants and ALT levels revealed that there were significant positive relationship between benzene (r = 0.45, P = 0.004) and styrene (r = 0.37, P = 0.034) with increased ALT concentrations.Conclusions:VOC exposure could be contributed to reduced liver function and impaired lipid profile. Therefore, proper preventive strategies seem to be necessary for reducing hazardous exposure.

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Section: Discussionmentioning

confidence: 99%

Volatile organic compounds as a preventive health challenge in the petrochemical industries

2019

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“…All these changes were neutralized when Vitamin E acetate cosupplemented with L-thyroxine. There are reports that Vitamin E acts as an antioxidant and improve the histology of male rat liver and kidney following cadmium-induced toxicity [57]. Sajitha et al [58] also reported that administration of Vitamin E has protected the histopathological and biochemical alterations induced by lead (Pb) intoxication in female Sprague-Dawley albino rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin E Acetate Supplementation on Thyroid Hormone-Sensitive Organs Following Exogenous L- Thyroxine Treatment

Sinha

Chakraborty

Mondal

et al. 2018

Asian J Pharm Clin Res

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Objective: L-thyroxine is used for control and prevention of many thyroidal diseases, though it may cause damages in thyroid hormone-sensitive organs, namely, liver and kidney. Reports on the protective effects of any antioxidants in L-thyroxine induced oxidative stress are scanty. Thus, L-thyroxine induced oxidative stress and its prevention by Vitamin E supplementation have been studied in the present investigation.Methods: Adult, male Wister rats were divided into four groups of six animals each, and L-thyroxine (T4) (0.3 mg/kg body weight) was administered intraperitoneally in the treated group. Similarly, L-thyroxine (T4), at the above-mentioned dose, and Vitamin E acetate (100 mg/kg of body weight/ day orally) coadministered simultaneously (T4+VE) in the next group. Third group was administered only with Vitamin E, and the remaining group kept as control. Treatment continued regularly for 15 and 30 days. Animals were sacrificed after completion of treatment. Lipid peroxidation (LPO) level, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities were assayed in liver and kidney along with their histology. Obtained results were interpreted statistically against their respective control groups.Results: Body weight was significantly decreased, and relative kidney weight was increased after L-thyroxine administration as compared to control (p<0.05). LPO level, SOD and catalase activities were significantly enhanced in L-thyroxine treated groups, whereas GPx activity was decreased. However, LPO level and the activities of those enzymes along with body weight and organ weights were almost restored their normal in L-thyroxine and Vitamin E coadministered group treated for 15 days and 30 days, respectively.Conclusion: Exogenously administered L-thyroxine causes oxidative stress in liver and kidney that in turn generates reactive oxygen species resulting cell damages. Vitamin E acetate supplementation reduces these adverse effects on liver and kidney and thus acts as a beneficial health management agent.

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“…Styrene monomer has been reported to be carcinogenic [7] and can cause various forms of damages to many tissues including the liver and kidneys [8], neuronal cells [9], and cochlear [10,11]. Although styrene monomer has been reported to markedly affect many tissues, little is known regarding its toxicity in skeletal muscle tissue.…”

Section: Introductionmentioning

confidence: 99%

Styrene Oxide Caused Cell Cycle Arrest and Abolished Myogenic Differentiation of C2C12 Myoblasts

Surinlert

Kongthong

Watthanard

et al. 2020

Journal of Toxicology

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Contaminations of chemicals in foods and drinks are raising public concerns. Among these, styrene, a monomer for plastic production, receives increasing interest due to its ability to leach from the packaging and contaminate in foods and drinks causing many health problems. The present study was designed to investigate the effects of styrene monomer (STR) and its metabolite styrene oxide (STO) on C2C12 myoblast proliferation and differentiation. Based on an MTT assay, both STR and STO showed no cytotoxic effect at 10–100 μM. However, at 50–100 μM STO, but not STR, significantly inhibited cell proliferation. The STO-treated cells were accumulated in S-phase of cell cycles as revealed by flow cytometry. The antioxidant enzyme (catalase and superoxide dismutase) activities and the gene expressing these enzymes of the arrested cells were decreased and ultimately led to nuclear condensation and expression of apoptotic markers such as cleaved caspase-3 and-9, but not cleaved caspase-8. In addition, STO significantly suppressed myogenic differentiation by decreasing both the number and size of differentiated myotubes. Biochemical analysis showed attenuations of total protein synthesis and myosin heavy chain (MHC) protein expression. In conclusion, a metabolite of styrene, STO, leached from plastic packaging of foods and beverages suppressed both myoblast proliferation and differentiation, which would affect skeletal muscle development and regeneration.

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The Preventive Effect of Vitamin C on Styrene-Induced Toxicity in Rat Liver and Kidney

Cited by 7 publications

References 31 publications

Volatile organic compounds as a preventive health challenge in the petrochemical industries

Volatile organic compounds as a preventive health challenge in the petrochemical industries

Effect of Vitamin E Acetate Supplementation on Thyroid Hormone-Sensitive Organs Following Exogenous L- Thyroxine Treatment

Styrene Oxide Caused Cell Cycle Arrest and Abolished Myogenic Differentiation of C2C12 Myoblasts

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