The preventive effects of asperuloside administration on dextran sodium sulfate-induced ulcerative colitis in mice

Abstract

However, there are no reports regarding the effects of asperuloside on ulcerative colitis. In this study, we examined the effects of asperuloside on a DSS-induced ulcerative colitis mouse model.

Chronic administration of Eucommia leaf extract (ELE) and asperuloside(ASP), the major component of ELE, prevents adipocyte hypertrophy in white adipose tissues

“…Obesity is characterized as hypertrophy and proliferation of adipocytes in white adipose tissue (WAT) [1,2]. Eucommia leaf extract (ELE) has been reported to have various bioactive properties [3][4][5][6][7][8][9][10][11], such as anti-obesity effects [6][7][8][9][10][11]. Asperuloside (ASP) is indicated as the major ingredient of ELE; it contributes to its anti-obesity effect [8,11].…”

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

“…In recent years, the study of Eucommia leaf extract (ELE) has been focused on its efficacy in maintaining human health. Reports on the biogenic effectiveness of ELE ingestion have identified the following benefits: 1) antihyperlipidemic effects that reduce visceral fat and suppress elevated levels of triglyceride and cholesterol in the blood [1][2][3][4][5][6][7]; 2) effects on bone, such as preventing the onset of postmenopausal osteoporosis and promoting calcium accumulation in osteoblasts [8][9][10]; 3) antihypertensive effects that slowly decrease blood pressure by maintaining the flexibility of the blood vessels and promoting arterial smooth muscle relaxation [2,11]; 4) rapid eye movement sleep and non-rapid eye movement sleep inducing effect [12]; and 5) preventative effects on ulcerative colitis by asperuloside, one of the major components of ELE [13]. Thus, ELE promotes systemic health.…”