1984
DOI: 10.1515/bchm2.1984.365.1.105
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The Primary Structure of μ-Chain-Disease Protein BOT. Peculiar Amino-Acid Sequence of the N-Terminal 42 Positions

Abstract: The complete primary structure of the mu heavy-chain disease (mu-HCD) protein BOT has been determined. The monomeric HCD-mu-chain consists of 391 amino-acid residues, lacking the VH and mu CH1 domains but including the entire CH2, CH3 and CH4 domains (349 residues). The sequence of the preceding 42 N-terminal residues which we designate as the "pre-C-part" presents no homology to any known variable or constant immunoglobulin sequence, but contains an internal homology of positions 10-19 to positions 20-29. The… Show more

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Cited by 11 publications
(2 citation statements)
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“…He died 3 1/2 months after the diagnosis was made. The p-heavy chain fragments from five patients (cases 1, 7, 8, 11, and 26) have been subjected to detailed chemical analysis by Franklin et al [30], Bakhshi et al [24], Barnikol-Watanabe et al [31], Mihaesco et al [32], Mihaesco et al [33], Lebreton et al [34,35], and Roussel et al [36]. Figure 1 depicts the structure of these five p H C D proteins compared with the normal p-heavy chain.…”
Section: Discussionmentioning
confidence: 99%
“…He died 3 1/2 months after the diagnosis was made. The p-heavy chain fragments from five patients (cases 1, 7, 8, 11, and 26) have been subjected to detailed chemical analysis by Franklin et al [30], Bakhshi et al [24], Barnikol-Watanabe et al [31], Mihaesco et al [32], Mihaesco et al [33], Lebreton et al [34,35], and Roussel et al [36]. Figure 1 depicts the structure of these five p H C D proteins compared with the normal p-heavy chain.…”
Section: Discussionmentioning
confidence: 99%
“…The nucleotide sequence and deduced amino acid sequence of the 0.7-kb insert cDNA of Wa-1 were completely identical with the C-terminal part of NEFA (named after DNA-binding domain, two EF-hands, Acidic amino acid rich region)/nucleobindin-2. 2 In immunoblots using the Wa-1 fusion protein, autoantibodies to Wa (NEFA/nucleobindin-2) were detected in 3 of 21 SSc (21%), one of 10 RA (10%) and one of 16 SLE sera (6%). However, neither RA nor SLE sera immunoprecipitated transfer RNA from HeLa cells, while all 3 SSc sera immunopricipitated transfer RNA, suggesting the diversity of autoepitopes among patient sera.…”
mentioning
confidence: 98%