Life skill development is very necessary to equip students to be able to live independently in the future, but there is no clear scheme regarding life skills education management, especially for students with disabilities. The purpose of this research was to develop a life skill education management model based on vocational for students with disabilities to be ready for work in the Business/ Industry. This type of research uses R & D cycle from Borg & Gall. Data collection was carried out through documentation studies, observations and in-depth interviews involving schools, PT Subang Autocomp Indonesia and parents of students and the validation of the research was conducted through Focus Group Discussion. The last, a limited trial was applied to two schools in Subang, namely SLB Waliwis Putih and SLBN Trituna. Research results shown that the management of life skills education for students with disabilities is arranged through (1) planning based on analysis and need assessment, (2) the implementation is carried out through school independence programs, basic training in training institutions and/or companies and internships in the Business/Industry world, (3) and evaluation is carried out through skills testing at school and the workplace by the Business/ Industry. The conclusion shown that the life skill education management model based on vocational that organized and synergistic can be equip students with disabilities for work. Therefore, this life skill education management model can be a solution in the development of life skills for students with disabilities.