The principle of detailed balancing, the iron-catalyzed disproportionation of hydrogen peroxide, and the Fenton reaction

Stanbury, David M.

doi:10.1039/d1dt03645a

Cited by 23 publications

(12 citation statements)

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“…Additionally, the simulations should not violate the principle of detailed balancing. 11 The role of phosphate in redirecting the product of the Fenton reaction to HO • needs to be experimentally investigated. 33,48…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the simulations themselves are questionable. 11 Indeed, as stated by Wieland and Franke 95 years ago, more information has been collected, but it has not yet led to more insight. However, a better understanding of the Fenton reaction can be obtained by exploring its energetics and the increase of its rate constant with pH.…”

Section: Introductionmentioning

confidence: 99%

“…However, this simulation has been questioned. 11 Thus, at low pH, there is no reason to invoke FeO 2+ as a product of the Fenton reaction. FeO 2+ is not an imaginary species: it is the product of the reaction of Fe 2+ with O 3 .…”

Section: Introductionmentioning

confidence: 99%

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Ferryl for real. The Fenton reaction near neutral pH

Koppenol¹

2022

Dalton Trans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ferryl for real. The Fenton reaction near neutral pH

Koppenol¹

2022

Dalton Trans.

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“…In 1937, Weiss explained the reaction mechanism of catalase: an anion H 2 O 2 reduces iron (III) to iron (II), and then iron (II) reduces H 2 O 2 to OH • and water, followed by chain reaction (5, 6), which is collectively referred to as the Haber–Weiss reaction. The mechanism of the Fenton reaction has studied and discussed, among which detailed equilibrium principles have been well summarized by Stanbury [ 24 ]. The Fenton reaction is affected by the environmental pH and concentration of iron.…”

Section: Fenton Reactionmentioning

confidence: 99%

Current Use of Fenton Reaction in Drugs and Food

Abe

Miyazawa

2022

Molecules

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Iron is the most abundant mineral in the human body and plays essential roles in sustaining life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction between iron and hydrogen peroxide, generating hydroxyl radical, which is highly reactive and highly toxic to living cells. “Ferroptosis”, a programmed cell death in which the Fenton reaction is closely involved, has recently received much attention. Furthermore, various applications of the Fenton reaction have been reported in the medical and nutritional fields, such as cancer treatment or sterilization. Here, this review summarizes the recent growing interest in the usefulness of iron and its biological relevance through basic and practical information of the Fenton reaction and recent reports.

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“…A solution of ferrous irons and hydrogen peroxide has been used as the Fenton reagent to oxidize organic molecules. However, the actual mechanism underlying the Fenton reaction remains controversial [ 24 ]; it is unknown whether free hydroxy radicals are generated or if a coordination complex of iron and hydrogen peroxide [for example, Fe(IV)=O] attack organic molecules [ 25 ]. It is also possible that iron binds weakly to an organic molecule, after which hydrogen peroxide reacts at the site.…”

Section: Basic Properties Of Ironmentioning

confidence: 99%

Iron-Induced Oxidative Stress in Human Diseases

Kawabata

2022

Cells

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Iron is responsible for the regulation of several cell functions. However, iron ions are catalytic and dangerous for cells, so the cells sequester such redox-active irons in the transport and storage proteins. In systemic iron overload and local pathological conditions, redox-active iron increases in the human body and induces oxidative stress through the formation of reactive oxygen species. Non-transferrin bound iron is a candidate for the redox-active iron in extracellular space. Cells take iron by the uptake machinery such as transferrin receptor and divalent metal transporter 1. These irons are delivered to places where they are needed by poly(rC)-binding proteins 1/2 and excess irons are stored in ferritin or released out of the cell by ferroportin 1. We can imagine transit iron pool in the cell from iron import to the export. Since the iron in the transit pool is another candidate for the redox-active iron, the size of the pool may be kept minimally. When a large amount of iron enters cells and overflows the capacity of iron binding proteins, the iron behaves as a redox-active iron in the cell. This review focuses on redox-active iron in extracellular and intracellular spaces through a biophysical and chemical point of view.

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The principle of detailed balancing, the iron-catalyzed disproportionation of hydrogen peroxide, and the Fenton reaction

Abstract: The iron-catalyzed disproportionation of H2O2 has been investigated for over a century, as has been its ability to induce the oxidation of other species present in the system (Fenton reaction)....

Cited by 23 publications

References 258 publications

Ferryl for real. The Fenton reaction near neutral pH

Ferryl for real. The Fenton reaction near neutral pH

Current Use of Fenton Reaction in Drugs and Food

Iron-Induced Oxidative Stress in Human Diseases

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