The principles of cancer treatment by chemotherapy

Caley, A.; Jones, R.

doi:10.1016/j.mpsur.2012.01.004

Cited by 32 publications

(34 citation statements)

References 6 publications

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“…Cancer is a leading cause of morbidity and mortality worldwide (World Health Organization, 2017). Today, the main problem of the administration of anticancer drugs is their toxicity, which causes severe side effects by damaging healthy cells along the chemotherapeutic process (Caley & Jones, 2012;Husseinia et al, 2013;Novak, Büchel, Keppler, & Jakupec, 2016). Classical anticancer drugs inhibit cell replication and transcription through the direct or indirect interaction with DNA, and induce mutagenic, cytotoxic, genotoxic and carcinogenic effects (Chen, Chang, & Cheng, 2017;Fonseca et al, 2017;Lin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Carnizello

Alves

Pereira

et al. 2018

J of Applied Toxicology

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Considering the promising previous results of ct‐[RuCl(CO)(dppb)(bipy)]PF6 (where dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine) as an antitumor agent, novel biological assays evaluating its toxicogenic potential were performed. The genotoxicity of the compound was evaluated by the in vitro micronucleus test (V79, Chinese hamster lung fibroblasts; HepG2, hepatocellular carcinoma cells), in vivo bone marrow micronucleus test and comet assay in hepatocytes (Swiss mice). The animals were treated with 0.63, 1.25, 2.5 and 5.0 mg/kg body weight (bw) of the compound. Negative (water) and positive (cisplatin, 1.5 mg/kg bw; methyl methanesulfonate, 40 mg/kg bw) controls were included. The parameters considered in the comet assay were the percentage of tail DNA, tail moment and tail length. The results of the in vitro micronucleus tests showed the absence of genotoxicity in V79 cells, while the compound was genotoxic in HepG2 cells at a concentration of 1.25 μm. In the in vivo micronucleus test, the compound was not genotoxic at the different doses evaluated. In the comet assay, only the dose of 5.0 mg/kg bw resulted in a significant increase in the frequency of DNA damage in hepatocytes when compared to the negative control. The genotoxic effect observed in HepG2 cells and in the liver comet assay indicates that the compound was metabolized by hepatic cells.

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Section: Introductionmentioning

confidence: 99%

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Carnizello

Alves

Pereira

et al. 2018

J of Applied Toxicology

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“…Chemotherapy is correctly described as cytotoxic therapy, and refers to the use of drugs to kill or inhibit the growth of cancer cells. Most chemotherapy drugs act as cytotoxic agents by causing damage to deoxyribonucleic acid (DNA) or prevent chromosomal replication by disrupting critical cell processes, which leads to cell death (apoptosis) [12]. There are other treatments that do not kill cancer cells and work by stopping cancer cell replication/division.…”

Section: Introductionmentioning

confidence: 99%

Prioritising anticancer drugs for environmental monitoring and risk assessment purposes

Booker

Halsall

Llewellyn

et al. 2014

Science of The Total Environment

140

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Anticancer drugs routinely used in chemotherapy enter wastewater through the excretion of the non-metabolised drug following administration to patients. This study considers the consumption and subsequent behaviour and occurrence of these chemicals in aquatic systems, with the aim of prioritising a selection of these drugs which are likely to persist in the environment and hence be considered for environmental screening programmes. Accurate consumption data were compiled from a hospital survey in NW England and combined with urinary excretion rates derived from clinical studies. Physical-chemical property data were compiled along with likely chemical fate and persistence during and after wastewater treatment. A shortlist of 15 chemicals (from 65) was prioritised based on their consumption, persistency and likelihood of occurrence in surface waters and supported by observational studies where possible. The ecological impact of these 'prioritised' chemicals is uncertain as the measured concentrations in surface waters generally fall below standard toxicity thresholds. Nonetheless, this prioritised sub-list should prove useful for developing environmental screening programmes.

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“…5,6 Platinum complexes are often also considered as alkylating agents as they form coordination bonds to DNA nucleobases. 2,7 The potency of platinum complexes in chemotherapy is unprecedented and they are used to treat many types of tumors. [8][9][10][11] However, their disadvantages, in particular, resistance development and side effects, have driven the development of metal complexes comprising metal centers other than platinum.…”

Section: Introductionmentioning

confidence: 99%

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

et al. 2015

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Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RAPTA scaffold, a well-established pharmacophore. While chlorambucil is known to alkylate DNA, the RAPTA complexes are known to coordinate to amino acid side chains of proteins. Therefore, such a molecule combines DNA and protein targeting properties in a single molecule. Several chlorambucil-tethered RAPTA derivatives were prepared and tested for their cytotoxicity, stability in water and reactivity to protein and DNA substrates. The anticancer activity of the complexes is widely driven by the cytotoxicity of the chlorambucil moiety. However, especially in the cisplatin-resistant A2780R cells, the chlorambucil-functionalized RAPTA derivatives are in general more cytotoxic than chlorambucil and also a mixture of chlorambucil and the parent organoruthenium RAPTA compound. In a proof-of-principle experiment, the cross-linking of DNA and protein fragments by a chlorambucil-RAPTA derivative was observed.

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The principles of cancer treatment by chemotherapy

Cited by 32 publications

References 6 publications

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Prioritising anticancer drugs for environmental monitoring and risk assessment purposes

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

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The principles of cancer treatment by chemotherapy

Cited by 32 publications

References 6 publications

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Prioritising anticancer drugs for environmental monitoring and risk assessment purposes

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Contact Info

Product

Resources

About

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays