The pro-oxidant activity of aluminum

Exley, Christopher

doi:10.1016/j.freeradbiomed.2003.11.017

Cited by 366 publications

(206 citation statements)

References 38 publications

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“…Functionally, oxidative stress induced protein oxidation, lipid peroxidations are almost synergistic in operation and former is operative earlier in plants (Gill and Tuteja 2011). The trend of the present observation for lipid peroxidation and protein carbamylation are also documented in other plant species prone to Al toxicity (Pan et al 2004;Exley 2004). Put, with its poly-cationic nature might have shielded the cellular membrane, particularly, the negatively charged domains of the unsaturated phospholipids backbones; those are more prone to oxidation by ROS.…”

Section: Discussionsupporting

confidence: 61%

“…It makes prudent that Al could be marked as an effective hazardous metal for inducing oxidative stress in plants. Essentially, plant tissues are also tuned to diminish this over oxidation by enzymatic and non-enzymatic pathways (Exley 2004). It is a sequential operation of some antioxidizing enzyme systems, those in chain of reactions resulted in cellular detoxification by the lysis of ROS.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidative responses of Salvinia (Salvinia natans Linn.) to aluminium stress and it’s modulation by polyamine

Mandal

Ghosh

Maiti

et al. 2012

Physiol Mol Biol Plants

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Antioxidative stress response of free-floating aquatic fern (Salvinia natans Linn.) was studied under increasing toxic amount of aluminium (Al) and its modulation by exogenous application of polymaine. Increased levels of superoxide (O 2 − ) and hydrogen peroxide (H 2 O 2 ) species from affected tissues suggested that plants were undergoing oxidative stress and it was concominant with increased accumulation of Al in a dose dependent manner. Application of polyamine like putrescine (Put) led to a decrease in oxidative stress as revealed by reduced level of O 2 − and H 2 O 2 . Al toxicity resulted into decreased biomass that was ameliorated by the application of Put. The changes observed in lipid peroxidation (MDA) and protein oxidation also indicated that plats are undergoing Al induced oxidative stress. In order to circumvent the oxidative stress resulting from Al toxicity, plants enzymatic and nonenzymatic antioxidant pathways were active. The ratio of both oxidized and reduced cellular glutathione exhibited significant variation in response to Al stress and was improved upon Put treatment. Peroxidase and glutathione were upregulated whereas catalse was downregulated under varying doses of Al. Isozyme profile of above enzymes also showed a trend with increasing amount of Al. The nuclear disintegration study using comet assay was indicative of Al induced oxidative stress. In the present study, we have explored the antioxidative response of aquatic fern Salvinia natans Linn in response to Al toxicity. The application of polyamine Put improved the overall antioxidative response and thus would make it a better candidate to be used as hyper accumulator of Al and other toxic metals.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Antioxidative responses of Salvinia (Salvinia natans Linn.) to aluminium stress and it’s modulation by polyamine

Mandal

Ghosh

Maiti

et al. 2012

Physiol Mol Biol Plants

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“…Aluminium-induced damage to body organs has been reported in several studies and accumulation in the kidney has been related to worsening renal func- tion [20,21]. Indeed the kidney may be exposed to high concentrations of aluminium during the normal process of renal excretion making kidney vulnerable to aluminium-mediated toxicity [22].…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

Abdel-Hamid

2014

Folia Histochem Cytobiol.

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Kidney is one of the most affected organs by aluminium toxicity. This study aimed to investigate the effect of aluminium chloride on the kidney of pregnant rats and to assess the efficiency of vitamin E and selenium in ameliorating this effect. Forty virgin albino rats were randomly divided into two main groups. Control rats were further divided into negative control group (C1, n = 10) which received distilled water and positive control group (C2, n = 10) that received vitamin E (VE, 150 mg/kg/day) and selenium (NaSe 150 µg/kg/day) for 3 months through intra-gastric tube. The experimental group was divided into an E1 subgroup in which rats received aluminium chloride (AlCl 3 , 150 mg/kg/day, n = 10) and E2 subgroup (n = 10) in which animals received the same dose of AlCl 3 plus VE and selenium at the same doses as C2 group for 3 months through intra-gastric tube. Conception of rats was allowed. AlCl 3 , VE and NaSe were given through intragastric tube during the whole length of the pregnancy, at the same doses as before pregnancy. At the 20th day of gestation dams were sacrificed, kidneys were dissected and processed for routine histological and immunohistochemical staining for identification of T-lymphocytes and macrophages. Integrated optical density of both cell types was assessed. AlCl3 administration induced histopathological changes in the kidney of pregnant rats and increased the density of CD3 and CD68 immunoreactive cells, suggestive of the associated aluminium-induced inflammatory process. Vitamin E and selenium minimized these harmful effects. The results suggest that diets rich in vitamin E and selenium and their supplements are advised particularly during pregnancy to alleviate the effects of possible excessive aluminium exposure.

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“…Humans are exposed to aluminum compounds from various sources as aluminum found in many food additives, toothpaste, medicines (such as aspirin), cheese, tea, cosmetics, drinking water, various household cookware and storage utensils; in addition aluminum is used to construct roofing and for many other industrial activities (Proudfoot, 2009). Exposure of humans to large quantity of aluminum leads to its accumulation in many organs, disturbing the pro-oxidant/antioxidant stability of tissues and causes lipid peroxidation (Exley, 2004). Aluminum inhibits enzymes such as hexokinase and, acid and alkaline phosphatases and, may bind to DNA and RNA (Kumar et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Açai in Combination with Vitamin C against Aluminum-Induced Toxicity in Rat Liver

Ahmed

Hamaad²

2017

JBLS

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Aluminum is associated with the pathogenesis of several diseases. Aç ai has recently emerged as a natural source of antioxidants. The present study was conducted to evaluate the protective effect of Aç ai in combination with vitamin C against the aluminum chloride induced toxicity. Seventy rats were divided into 7 groups:-Group (GP) 1: control group, GP 2: treated with AlCl3, GP 3: treated with Aç ai, GP 4: treated with vitamin C, GP 5: treated with AlCl3 and Aç ai , GP 6: treated with AlCl3 and vitamin C, GP 7: treated with AlCl3, Aç ai and vitamin C. After 4 weeks, blood and liver specimens were collected to evaluate biochemical alterations and hepatic antioxidant and inflammatory parameters. AlCl3 treatment decreased liver enzymes (alanine aminotransferase, aspartate amino transferase, alkaline phosphatase), tumor necrosis factor-α and IL-6 while hepatic malondialdehyde was elevated. In contrast, hepatic glutathione, super oxide dismutase, catalase were decreased. Aç ai and vitamin C treatment improved the adverse effects induced by AlCl3, while co-administration with vitamin C promoted the action of aç ai on hepatic damage and antioxidant parameters. Aç ai showed a protective effect against AlCl3 induced toxicity, particularly in combination with vitamin C.

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The pro-oxidant activity of aluminum

Cited by 366 publications

References 38 publications

Antioxidative responses of Salvinia (Salvinia natans Linn.) to aluminium stress and it’s modulation by polyamine

Antioxidative responses of Salvinia (Salvinia natans Linn.) to aluminium stress and it’s modulation by polyamine

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

Protective Effects of Açai in Combination with Vitamin C against Aluminum-Induced Toxicity in Rat Liver

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