The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids

Rietjens, Ivonne M. C. M.; Boersma, Marelle G.; Haan, Laura de; Spenkelink, Bert; Awad, Hanem M.; Cnubben, N.H.P.; Zanden, Jelmer J. van; Woude, Hester van der; Alink, G.M.; Koeman, J.H.

doi:10.1016/s1382-6689(02)00003-0

Cited by 332 publications

(248 citation statements)

References 80 publications

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“…In accordance with our results, Korkmaz et al [25] reported that vitamin C co-administration along with BPA aggravated oxidative damage in the liver of male rats. Such an effect of vitamin C in this study might be due to its prooxidant impact, where vitamin C converts Fe 3+ into Fe 2+ , which reacts with oxygen and hydrogen peroxide resulting in formation of hydroxyl radicals and superoxide anions [25,36]. Supporting our results, Sakagami and Satoh [37] also reported that the addition of ascorbic acid to the culture medium increased dose-dependently the oxidation potential and acted as a prooxidant for the induction of apoptotic cell death.…”

Section: Discussionsupporting

confidence: 85%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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Section: Discussionsupporting

confidence: 85%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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“…This dual behavior have been attributed to reaction variables like reagents concentration and pH (84,85) . Between these are highlighted flavonoids (86) , carotenoids, ascorbic acid, tocopherols (87) and DHB (88)(89)(90)(91) .…”

Section: Ligands Effects On Fenton Reactionmentioning

confidence: 99%

Fenton Reaction Driven by Iron Ligands

Salgado

Melín

Contreras

et al. 2013

J. Chil. Chem. Soc.

107

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One of the most important sources of reactive oxygen species (ROS) in biological systems is the Fenton reaction. In this, the Fe 2+ or Fe 3+ reacts with H 2 O 2 to produce ROS as the hydroxyl radical (•OH), superoxide radical (O 2 •-) and singlet oxygen ( 1 O 2 ). The main ROS, responsible for the high oxidizing power of the Fenton reaction, is not clear. Some authors claim that the principal reactive species is •OH, while others propose a ferryl specie (Fe 4+ or [FeO] 2+ ) (1,2) . Recently, have been proposed that the kind of reaction species produced depends mainly of pH and the iron composition of the coordination sphere. This is highlighted for Fe 3+ , because in mono and (some) bis-complexes Fe 3+ is reduced to Fe 2+ and there are some positions occupied by water or hydroxide ligands, readily to be exchanged by H 2 O 2 . On the other hand, in tris-complexes there are not any positions occupied by water or hydroxide, avoiding the formation of peroxo-complexes, necessary for Fenton or Fenton like reaction.The 1,2-dihydroxybenzenes (DHBs) have been described as modulators of Fenton reaction. The DHBs driven Fenton reaction have been used for environmental applications as an advanced oxidation process. Furthermore, these systems participate in different biological process, as the wood biodegradation by fungi and oxidative stress in neurodegenerative diseases.In this review, the effect of 1,2-dihydroxybenzenes on the activated species production by the Fenton and Fenton like reaction will be discussed and its participation in different systems.

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“…This has to be carefully done especially to maintain the chemical and pharmacological aspects of pepper (Rietjens et al, 2002). A number of factors, including pH, oxygen concentration, moisture content, temperature and metallic acid catalysts (Uddin et al, 2002), influence vitamin C activity.…”

Section: Introductionmentioning

confidence: 99%

Drying kinetics, structural characteristics and vitamin C retention of dedo-de-moça pepper (Capsicum baccatum) during convective and freeze drying

Véras

Béttega

Freire

et al. 2012

Braz. J. Chem. Eng.

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-The main objective of this study was to evaluate the effect of the drying process on the vitamin C levels and physical properties of dedo-de-moça pepper. The drying kinetics and the structural properties were determined as a function of moisture content. Convective drying was compared with freeze-drying in terms of product quality, structural properties, retention of vitamin C and rehydration characteristics. Empirical and semi-empirical equations were used to describe the drying and rehydration kinetics. Nonlinear analysis applied to results of convective drying, based on curvature measures and bias measures, showed that the only equation that gives good inference results based on least squares estimators is the Overhults equation. The characterization of the rehydration process was done by determining the indexes that take into account the water absorption capacity and solutes losses. The material dried by lyophilization show greater potential to rehydrate.

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The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids

Cited by 332 publications

References 80 publications

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Fenton Reaction Driven by Iron Ligands

Drying kinetics, structural characteristics and vitamin C retention of dedo-de-moça pepper (Capsicum baccatum) during convective and freeze drying

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