The (pro)renin receptor in health and disease

Ichihara, Atsuhiro; Yatabe, Midori

doi:10.1038/s41581-019-0160-5

Cited by 106 publications

(118 citation statements)

References 267 publications

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“…PRR inhibition or knockdown in vivo leads to reduction in both the mass of WAT and the size of adipocytes . Although PRR activates the intracellular ERK1/2 signalling cascade , its role in the regulation of adiposity is instead attributed to enhanced processing of Agt into AngI and not by specific signalling triggered by this receptor . Recent data suggest that soluble PRR induces beiging of WAT in mice, but the mechanism is not yet known .…”

Section: Ras In the Regulation Of White Adipose Tissue Functioningmentioning

confidence: 99%

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

et al. 2020

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Obesity is often associated with high systemic and local renin–angiotensin system (RAS) activity in adipose tissue. Adipose‐derived mesenchymal stem/stromal cells (ADSCs), responsible for adipose tissue growth upon high‐fat diet, express multiple angiotensin II receptor isoforms, including angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), Mas and Mas‐related G protein‐coupled receptor D. Although AT1R is expressed on most ADSCs, other angiotensin receptors are co‐expressed on a small subpopulation of the cells, a phenomenon that results in a complex response pattern. Following AT1R activation, the effects are transient due to rapid receptor internalisation. This short‐lived effect can be prevented by heteromerisation with AT2R, a particularly important strategy for the regulation of ADSC differentiation and secretory activity. Heteromeric AT2R might be especially important for the generation of thermogenic beige adipocytes. This review summarises current data regarding the regulation of adipose tissue renewal and particularly ADSC adipogenic differentiation and secretory activity by RAS, with an emphasis on AT2R and its effects. We reveal a new scheme that implicates AT2R into the regulation of ADSC hormonal sensitivity.

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Section: Ras In the Regulation Of White Adipose Tissue Functioningmentioning

confidence: 99%

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

et al. 2020

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“…These biomarkers are: renin receptor, caspase 3, KIM-1, and NF-κB. Renin receptor has been reported to contribute to the pathogenesis of disease conditions such as fibrosis, AKI, cardiovascular disease, diabetic microangiopathy, preeclampsia, cancer hypertension, and obesity [61]. In this study, ramipril along with pioglitazone caused a significant inhibition of renin receptor.…”

Section: Discussionmentioning

confidence: 63%

Ramipril blunts glycerol-induced acute renal failure in rats through its antiapoptosis, anti-inflammatory, antioxidant, and renin-inhibiting properties

Adedapo

Osaretin

Falayi

et al. 2020

Journal of Basic and Clinical Physiology and Pharmacology

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ObjectivesAcute kidney injury (AKI) is a malady with a sudden onset resulting in buildup of waste matters in the body, but a specific cure hasn’t been found as a lasting solution to AKI. In this study, ramipril was evaluated for its potential therapy in glycerol-induced AKI in rats.MethodsTwenty animals were divided into four groups of five animals each. Group I was the control while group II was given glycerol on day 8 only, groups III and IV were administered with pioglitazone (reference drug) and ramipril for seven days respectively and on day 8 received glycerol. On the ninth day, blood and tissue samples were taken to assay for serum indicators of oxidative damage, enzymatic and nonenzymatic antioxidants, and creatinine and blood urea nitrogen. Animals were sacrificed thereafter; kidney was harvested for histological and immunohistochemical analysis. Expressions of caspase 3, renin receptor, NK-KB, and KIM-1 were carried out.ResultsRamipril significantly inhibited indicators of oxidative damage while also significantly increasing levels of enzymatic and nonenzymatic antioxidant markers. These drugs also significantly lowered the levels of creatinine and blood urea nitrogen. Histology also indicated that while there were massive infiltration of leucocytes and congestion of the kidney in toxicant group, the ramipril-treated group showed a milder condition. In immunohistochemistry, the two drugs significantly inhibited the expressions of the four proteins, which were highly expressed in the toxicant group.ConclusionsThe study showed that ramipril and pioglitazone have nephroprotective effect and thus have the ability to blunt AKI through their anti-inflammatory, antiapoptosis, antirenin, and antioxidant properties.

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“…Those two brain‐enriched trans‐membrane proteins are accessory components of the vATPase with some additional cellular functions—for example, ATP6AP1 is involved in the vATPase transport and exocytosis, and ATP6AP2 is reported to be essential for biogenesis of active vATPases . ATP6AP2 is also ideally posed to link vATPase to cell signaling, for example, the renin‐angiotensin system for regulating blood pressure and electrolyte balance, as well as Wnt signaling during embryo development . The functions of ATP6AP1 and ATP6AP2 at the mammalian synapse are not yet well understood and require further study.…”

Section: Mechanisms Of Sv (Re)acidificationmentioning

confidence: 99%

Regulation of synaptic vesicle acidification at the neuronal synapse

Gowrisankaran

Milošević

2020

IUBMB Life

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The vacuolar H+‐adenosine triphosphatases (vATPases) acidify multiple intracellular organelles, including synaptic vesicles (SVs) and secretory granules. Acidification of SVs represents a critical point during the SV cycle: without acidification, neurotransmitters cannot be loaded into SVs. Despite the obvious importance of the vesicle acidification process for neurotrasmission and the life of complex organisms, little is known about the regulation of vATPase at the neuronal synapse. In addition, the composition of the vATPase complex on the SVs is unclear. Here, we summarize the key features of vATPase found on SVs, and propose a model of how vATPase activity is regulated during the SV cycle. It is anticipated that the information from the SV lumen is communicated to SV surface in order to signal successful acidification and neurotransmitter loading: we postulate here that the regulators of the vATPase activity exist (e.g., Rabconnectin‐3) that promote the recruitment of SV peripheral proteins and, consequently, SV fusion.

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The (pro)renin receptor in health and disease

Cited by 106 publications

References 267 publications

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

Ramipril blunts glycerol-induced acute renal failure in rats through its antiapoptosis, anti-inflammatory, antioxidant, and renin-inhibiting properties

Regulation of synaptic vesicle acidification at the neuronal synapse

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