The probability of pregnancy after embryo transfer is affected by the age of the patient, cause of infertility, number of embryos transferred and the average morphology score, as revealed by multiple logistic regression analysis

Abstract

Because the process of conception is affected by many variables, a multiple logistic regression analysis was performed to assess (i) the impact and relative weight of both patient and embryo variables and (ii) their possible effects on the probability of a vital pregnancy after embryo transfer. A statistical model was constructed predicting the probability of pregnancy after embryo transfer. The variables that contributed significantly to the predictive value of the model were the age of the patient, the cause of infertility, the number of embryos transferred and the average morphology score of the transferred embryos. Embryo variables appeared to have a significant but modest value in predicting the probability of pregnancy after embryo transfer. Other variables, such as the thickness of the endometrium, were found to have no prognostic value. Moreover, we found that their effect could be explained by the variables already included in the model.

The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transfer

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The impact of the woman's age on the success of standard and donor in vitro fertilization

“…Therefore, these cutoff points should not be consid ered too strictly. The authors of a recent study on standard IVF reported that they could not demon strate a change in age effect (25). However, as they included age only as a (log)linear variable in the model, it was not possible (by definition) to find a change in trend.…”

Examination of bacterial contamination at the time of embryo transfer, and its impact on the IVF/pregnancy outcome

“…This has largely been attributed to variables such as the patient's age, endometrial receptivity, embryo quality [1,2] and embryo transfer technique per se [3][4][5]. As in vitro fertilization treatment (IVF) involves the placement of embryos into the uterine cavity using a catheter that passes through the cervix, the possibility of bacterial contamination during the embryo transfer procedure clearly exists, but has been poorly explored.…”