The Probable Chemical Nature of Crown‐gall Tumor‐inducing Principle

Klein, Richard M.

doi:10.1002/j.1537-2197.1953.tb06526.x

Cited by 11 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the first phase the bacteria, in co-operation with host cells at a certain stage of wound-healing, produce a substance, the socalled tumour-inducing principle (TIP). This substance is believed to belong to the nucleic acids (KLEIN 1953(KLEIN , 1954. The wounding is interpreted as playing a further role in tumour induction.…”

Section: ) Agents Determining the Development Of Crown Gallmentioning

confidence: 98%

See 1 more Smart Citation

Dedifferentiation and Differentiation of Cells in Crown Gall ofVicia Faba

Therman

1956

Caryologia

View full text Add to dashboard Cite

Section: ) Agents Determining the Development Of Crown Gallmentioning

confidence: 98%

“…of the inoculation, according to KLEIN (1953). This level is maintained until 48 hrs., and thereafter it falls to the control level by 72 hrs.…”

Section: ) Agents Determining the Development Of Crown Gallmentioning

confidence: 99%

Dedifferentiation and Differentiation of Cells in Crown Gall ofVicia Faba

Therman

1956

Caryologia

View full text Add to dashboard Cite

“…The alterative phase depends on infection with A. tumefaciens. It is further subdivisible into two subperiods (Klein, 1953). The first or 'conditioning' sub-period, lasting less than 24 hr., leads to the production of a specific tumour-inducing principle or substance (T.I.P.)…”

Section: (I) Vertebratesmentioning

confidence: 99%

“…The bacterial T.I.P. is also temperature-sensitive from the second to the fifth day after inoculation, being destroyed as fast as formed at 32' C. and above (Klein, 1953). In certain plant species, tumour formation will only occur at or below 25' C. A minimum time of 10 hr.…”

Section: (I) Vertebratesmentioning

confidence: 99%

“…Klein (1953) claims that the agent is 'not a true virus', and others state that only temporary growths are thus inducible. Klein & Klein (1953) have shown that metabolic products, Cancer biology 487 and in some cases purified desoxyribonucleic acid, from virulent A . tumefaciens can transform related bacteria; they irreversibly confer virulence (i.e.…”

Section: (I) Vertebratesmentioning

confidence: 99%

See 1 more Smart Citation

CANCER BIOLOGY: COMPARATIVE and GENETIC*

Huxley¹

1956

Biological Reviews

View full text Add to dashboard Cite

SUMMARY I employ cancer in a broad sense to cover all products of malignant neoplasia– carcinomas, sarcomas, leukaemias and ascites tumours–and tumour to cover all autonomous neoplasms. Cancer is not a biological entity, but an assemblage of many distinct diseases (malignant tumours) which share the following symptoms: (a) replication of abnormal tissue type, but often with change towards greater malignancy; (b) non‐limited proliferation; (c) some degree of histological and physiological dedifferentiation;(d) partial or often complete lack of organization; (c) invasiveness, often accompanied by metastasis. Neoplasia also includes the development of benign tumours, which exhibit symptoms (a)‐(d) above, and have therefore acquired autonomy. Neoplasia does not involve an abnormal form of tissue differentiation, but a characteristic deviation of metabolism which may affect any type of tissue. Tumours retain the specific determination of the tissues from which they arise, though in hypoplastic manifestation. Tumorigenic metabolic deviation proceeds by a series of individual chance (mutational) events, instead of by a continuous (statistical) process affecting all cells simultaneously as in normal differentiation. All autonomous neoplasms can be regarded as the equivalents of new biological species. Though the tumours of lower vertebrates, invertebrates and plants often differ in various ways from those of mammals and birds, there is no reason for regarding them as irrelevant to the human cancer problem. They are autonomous and often malignant neoplasms, and have sometimes been experimentally induced. Neoplastic tumours, whether spontaneous (in nature) (S), experimentally induced (E), or genetically induced (G), have been recorded in the following groups of organisms: The ‘cancer spectrum’ may differ markedly in different groups, species and breeds. High cancer‐proneness exists in some animal species (e.g. dogs, mice, budgerigars, domestic fowls, poecilid and cyprinodont fish) and breeds (retrievers, grey horses, some domesticated goldfish), and low cancer‐proneness in others (guinea‐pigs, rabbits, pigs, primates; Pekinese, chows). Thyroid tumours develop frequently in salmonids and some other fish in water of low oxygen content. Their invasiveness is usually not an effect of malignancy, but of the absence of a capsule in the fish thyroid. Attention is drawn to the favourable material for cancer research provided by regions of high localized growth rate (horns, horn cores, antlers, etc.), growth gradients (crustacean appendages and abdomina, molluscan mantle edges, etc.), endocrine‐dependent growth and regression (fowl‐combs, larval and metamorphosing Amphibia, stick insects, etc.), nerve‐dependent differentiation (Orthoptera), regenerating limbs (Amphibia, Crustacea, stick* insects, etc.), late‐fertilized Amphibian eggs, graft‐tolerant sites (cheek pouches of hamster), crown‐gall tumours and other plant galls, and toadstools. The rate of development of spontaneous and induced tumours is related to size of species. ...

show abstract

Entwicklungsphysiologie

Lang¹

1954

Bericht Über Das Jahr 1953

View full text Add to dashboard Cite

The Probable Chemical Nature of Crown‐gall Tumor‐inducing Principle

Cited by 11 publications

References 10 publications

Dedifferentiation and Differentiation of Cells in Crown Gall ofVicia Faba

Dedifferentiation and Differentiation of Cells in Crown Gall ofVicia Faba

CANCER BIOLOGY: COMPARATIVE and GENETIC*

Entwicklungsphysiologie

Contact Info

Product

Resources

About