2023
DOI: 10.1007/s13760-023-02403-x
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The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

Naif H. Ali,
Hayder M. Al-kuraishy,
Ali I. Al-Gareeb
et al.

Abstract: Alzheimer’s disease (AD) is the most common type of dementia associated with amyloid beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the accumulation of Aβ. The plasminogen-activating system (PAS) is controlled by various enzymes like tissue plasminogen activators (tPA). Neuronal tPA enhances the conversion of plasminogen to plasmin, which cleaves Aβ; this function is controlled by many inhibitors of PAS, including a plasminogen-activating inhibitor (PAI-1) and neuroserpin. Therefo… Show more

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Cited by 6 publications
(3 citation statements)
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“…Here, we detected the dysregulation of thyroid hormone synthesis, mostly in the visual cortex of KO animals, though mediated through other proteins ( Figure 5 ). Interestingly, our interactome analysis suggests the perturbation of proteins involved in amyloid-beta and tau protein regulation which play key roles in neurodegenerative disorders such as AD [ 70 ].…”
Section: Discussionmentioning
confidence: 99%
“…Here, we detected the dysregulation of thyroid hormone synthesis, mostly in the visual cortex of KO animals, though mediated through other proteins ( Figure 5 ). Interestingly, our interactome analysis suggests the perturbation of proteins involved in amyloid-beta and tau protein regulation which play key roles in neurodegenerative disorders such as AD [ 70 ].…”
Section: Discussionmentioning
confidence: 99%
“…Both Aβ and NFTs alter the synapses and neuronal circuit resulting in cognitive dysfunction and impairment of the synthesis and the release of BDNF from brain neurons. 52 , 53 , 54 In addition, depletion of neuronal BDNF promotes the accumulation of Aβ and NFTs and induces the development of synaptic dysfunction, apoptosis and neuroinflammation. 55 Deficiency of BDNF synthesis is extremely reduced in AD disease due to the progressive intracellular accumulation of NFTs and associated neurodegeneration.…”
Section: Bdnf and Neurodegenerative Diseasesmentioning
confidence: 99%
“…Furthermore, AD neuropathology is linked to NFTs, which are caused by hyperphosphorylated tau protein aggregation rather than Aβ (Sengoku 2020 ; Alrouji et al 2023 ; Ali et al 2023 , 2024 ). Tau protein is a small peptide, controls the stability of neuronal microtubules, synaptic plasticity, and axonal transport.…”
Section: Introductionmentioning
confidence: 99%