Purpose. Development of a methodology for optimizing the technological parameters of the airlift operation, based on the analysis of the pressure balance in the annulus and in the drill string that occurs during drilling. Methodology. The tasks were solved by a complex research method, which includes a review and generalization of literary and patent sources, analytical studies on existing methods for optimizing the technological parameters of drilling with reverse circulation using an airlift. Findings. It has been established that in the study on the airlift circulation method during rotary drilling with reverse circulation, an important role is played by the analysis of the pressure balance arising in the course of drilling in the annulus and in the drill string. It takes into account both hydrostatic pressures and pressure losses for pumping water and water-air mixture. A technique has been developed for assessing the effect of rate of penetration on circulation parameters. Originality. For the first time, it has been shown that the analysis of the pressure balance makes it possible to establish, with a given accuracy, the average effective values of the output parameters: the density of the water-air mixture, its upward flow rate, and the air flow rate at a given velocity of the upward flow of water as it approaches the mixer. Practical value. The proposed technique makes it possible to establish the dependence of the values of the output parameters on the depth of the well, as well as the required compressor performance to provide a given drilling fluid flow rate.