The problem of maternal toxicity in developmental toxicity studies

Giavini, Erminio; Menegola, Elena

doi:10.1016/j.yrtph.2011.11.021

Cited by 14 publications

(7 citation statements)

References 13 publications

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“…The possible mechanisms of vanadium embryo-fetal toxicity may involve different aspects, one of which may be maternal toxicity, such as in the 18.7 mg/kg/day V 2 O 4 treatment group, where some females only showed scarring in the uterine horn and resorption, indicating fetal death. This is consistent with some authors' suggestions that there is a correlation between the severity of maternal toxicity and the effects on the conceptuses, 42,59 since factors that can disrupt homeostasis in the dam may also affect the development of her progeny. 42 Both of these effects were observed in this study.…”

Section: Embryo and Fetal Toxicitysupporting

confidence: 92%

Vanadium(IV) oxide affects embryonic development in mice

Álvarez‐Barrera¹,

Rodríguez‐Mercado²,

Mateos-Nava³

et al. 2022

Environmental Toxicology

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Vanadium(V) and vanadium(IV) are the predominant redox forms present in the environment, and epidemiological studies have reported that prenatal vanadium exposure is associated with restricted fetal growth and adverse birth outcomes. However, data about the toxic effects of vanadium(IV) oxide (V2O4) on the development of mammals are still limited. Therefore, in this work, 4.7, 9.4, or 18.7 mg/kg body weight/injection/day V2O4 was administered through an intraperitoneal (ip) injection to pregnant mice from gestational days 6 to 16. The results showed that V2O4 produced maternal and embryo‐fetal toxicity and external abnormalities in the offspring, such as malrotated and malpositioned hind limbs, hematomas and head injuries. Moreover, the skeletons of the fetuses presented reduced ossification of the cranial bones, including the frontal and parietal bones, corresponding to head injuries observed in the external assessment of the fetuses. These results demonstrate that administration of V2O4 to pregnant females in the organogenesis period adversely affects embryonic development.

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Section: Embryo and Fetal Toxicitysupporting

confidence: 92%

Vanadium(IV) oxide affects embryonic development in mice

Álvarez‐Barrera¹,

Rodríguez‐Mercado²,

Mateos-Nava³

et al. 2022

Environmental Toxicology

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“…A possible etiological factor for embryo deaths and fetal malformations is maternal toxicity [70,71,72]. Collins et al suggested that FB 1 was not teratogenic but that developmental variations induced by the mycotoxin were secondary to maternal toxicity.…”

Section: Mechanisms Through Which the Fb1 Exerts Its Developmentalmentioning

confidence: 99%

Developmental Toxicity of Mycotoxin Fumonisin B1 in Animal Embryogenesis: An Overview

Lumsangkul

Chiang

et al. 2019

Toxins

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A teratogenic agent or teratogen can disturb the development of an embryo or a fetus. Fumonisin B1 (FB1), produced by Fusarium verticillioides and F. proliferatum, is among the most commonly seen mycotoxins and contaminants from stale maize and other farm products. It may cause physical or functional defects in embryos or fetuses, if the pregnant animal is exposed to mycotoxin FB1. Due to its high similarity in chemical structure with lipid sphinganine (Sa) and sphingosine (So), the primary component of sphingolipids, FB1 plays a role in competitively inhibiting Sa and So, which are key enzymes in de novo ceramide synthase in the sphingolipid biosynthetic pathway. Therefore, it causes growth retardation and developmental abnormalities to the embryos of hamsters, rats, mice, and chickens. Moreover, maternal FB1 toxicity can be passed onto the embryo or fetus, leading to mortality. FB1 also disrupts folate metabolism via the high-affinity folate transporter that can then result in folate insufficiency. The deficiencies are closely linked to incidences of neural tube defects (NTDs) in mice or humans. The purpose of this review is to understand the toxicity and mechanisms of mycotoxin FB1 on the development of embryos or fetuses.

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“…Adverse developmental outcomes that occur at doses that do not elicit maternal toxicity are of greater concern, as this signifies a selective toxicity on the developing conceptus [44][45][46]. On the contrary, developmental effects on the offspring that occur at dose levels where the mother is also affected can signify fetal toxicity that is induced secondary to maternal effects.…”

Section: Developmental Toxicity Definitive Study (Oecd 414)mentioning

confidence: 99%

A Developmental and Reproductive Toxicology Program for Chemical Registration

Johnson

Hannas

Marty

et al. 2016

Methods in Pharmacology and Toxicology

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The goal of the chapter is to outline the process of testing molecules for potential developmental and reproductive toxicity (DART). Here, the entire process of DART testing is discussed, from the regulatory use of DART data to the conduct and interpretation of the various DART study designs. Although nonanimal DART testing strategies are envisioned by the new science of "21st Century Toxicity Testing", these high-content, high-throughput testing paradigms are not sufficiently mature from a scientific perspective to be acceptable on their own by regulatory agencies for chemical registration. Thus, these testing paradigms are not included in this chapter. While the scope of the chapter is broad, it is beyond the range of this chapter to describe all possible scenarios encountered in DART testing. For additional information, the reader is referred to other recent publications on this topic. The chapter is organized in a stepwise manner into three main topics: (1) Use of DART studies for chemical registration; (2) General considerations for all DART study designs; and (3) Descriptions of all DART study designs from a practical perspective, beginning with an initial range-finding study and ending with the complex Extended One-Generation Reproductive Toxicity Study (EOGRTS).

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The problem of maternal toxicity in developmental toxicity studies

Cited by 14 publications

References 13 publications

Vanadium(IV) oxide affects embryonic development in mice

Vanadium(IV) oxide affects embryonic development in mice

Developmental Toxicity of Mycotoxin Fumonisin B1 in Animal Embryogenesis: An Overview

A Developmental and Reproductive Toxicology Program for Chemical Registration

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