2018
DOI: 10.1016/j.placenta.2018.06.311
|View full text |Cite
|
Sign up to set email alerts
|

The problem with using the birthweight:placental weight ratio as a measure of placental efficiency

Abstract: The BW:PW ratio produced an artefact whereby histologically less mature placentas at term appeared to be more "efficient" than mature placentas, illustrating a known problem with the use of ratios. For other traits, residuals generally showed differences between placentas with and without pathology that were as great as those seen with BW:PW ratios, and often showed stronger associations with adverse outcomes.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

2
26
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 27 publications
(28 citation statements)
references
References 24 publications
2
26
0
Order By: Relevance
“…A low fetal/placental weight score was an additional independent predictor of early FGR, suggesting that placental efficiency (placental nutrient transport per unit of placental weight) was significantly reduced in this category compared with late fetal growth failure. 18 In the univariate analysis, the score given to represent the number and severity of lesions suggestive of fetal vascular malperfusion was higher among FGR pregnancies (both normotensive and hypertensive) than controls; however, the fetal obstructive pattern was similar between early and late FGR. These findings are consistent with previous data on small-for-gestational-age pregnancies, suggesting that maternal but not fetal vascular malperfusion lesions are more common among early-onset FGR than late-onset FGR.…”
Section: Discussionmentioning
confidence: 93%
See 2 more Smart Citations
“…A low fetal/placental weight score was an additional independent predictor of early FGR, suggesting that placental efficiency (placental nutrient transport per unit of placental weight) was significantly reduced in this category compared with late fetal growth failure. 18 In the univariate analysis, the score given to represent the number and severity of lesions suggestive of fetal vascular malperfusion was higher among FGR pregnancies (both normotensive and hypertensive) than controls; however, the fetal obstructive pattern was similar between early and late FGR. These findings are consistent with previous data on small-for-gestational-age pregnancies, suggesting that maternal but not fetal vascular malperfusion lesions are more common among early-onset FGR than late-onset FGR.…”
Section: Discussionmentioning
confidence: 93%
“…In our study, increased rates of early infarcts suggesting placental ischemia, distal villous hypoplasia suggesting a reactive proliferating pattern to hypoxia, acute atherosis and persistent endovascular trophoblasts indicating defective remodeling of spiral arteries and decidual arteriopathy were independently correlated with early rather than late FGR. A low fetal/placental weight score was an additional independent predictor of early FGR, suggesting that placental efficiency (placental nutrient transport per unit of placental weight) was significantly reduced in this category compared with late fetal growth failure …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent literature argues that the FPW is not truly a measure of placental efficiency with histological parameters proving more important. 20 It is likely that due to the low incidence of severe placental disease within our low-risk study population that there are not enough cases of severe preeclampsia to demonstrate a difference in aspirin use on placental histopathology and that future studies should separate early-and late-onset placental disease cases in analysis. Study strengths include that data originate from an RCT with a robust methodology.…”
Section: Discussionmentioning
confidence: 94%
“…We excluded pregnancies where the gestational age was over 43 weeks; gestational age was calculated based on the last menstrual period to the nearest week. Within each gestational age category (described below), birthweights and placental weights were corrected for maternal race, offspring sex and gestational age using a general linear model, after first removing the top and bottom 0.5% of raw birthweights and placenta weights within each gestational age category to objectively exclude biologically implausible values [40]. Pregnancies ending before 24 weeks were excluded from all analyses except those of spontaneous abortions.…”
Section: Methodsmentioning
confidence: 99%