The PROCAINA (PROstate CAncer INdication Attitudes) Project (Part I): a survey among Italian radiation oncologists on postoperative radiotherapy in prostate cancer

Bari, Berardino De; Alongi, Filippo; Franco, Pierfrancesco; Ciammella, Patrizia; Chekrine, T.; Livi, Lorenzo; Jereczek-Fossa, Barbara A.; Filippi, Andrea Riccardo; Young, Airo

doi:10.1007/s11547-012-0913-8

Cited by 20 publications

(6 citation statements)

References 42 publications

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“…40 Gy in five fractions) may further enhance therapeutic ratio of this approach and exploit all its potential benefit. These results could prompt significant shifts in routine postoperative management of prostate cancer [ 27 ] and use of stereotactic radiotherapy for oligorecurrent disease [ 28 ]. Even if these results seem to be very promising, longer follow-up is needed to better understand the improvement showed by SSRT in terms of acute/late side effects and clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic or conventional radiotherapy for macroscopic prostate bed recurrence: a propensity score analysis

et al. 2022

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Purpose To assess outcomes between salvage radiation therapy (SRT) with curative intent and stereotactic radiotherapy for macroscopic prostate recurrence (SSRT) after radical prostatectomy (RP). In order to compare these two different options, we compared their outcomes with a propensity score-based matched analysis. Methods Data from 185 patients in seven Italian centres treated for macroscopic prostate bed recurrence after RP were retrospectively collected. To make a comparison between the two treatment groups, propensity matching was applied to create comparable cohorts. Results After matching, 90 patients in the SRT and SSRT groups were selected (45 in each arm). Kaplan–Meier analysis did not show any significant differences in terms of BRFS and PFS between matched populations ( p = 0.08 and p = 0.8, respectively). Multivariate models show that treatment was not associated with BRFS, neither in the whole or matched cohort, with HR of 2.15 (95%CI 0.63–7.25, p = 0.21) and 2.65 (95%CI 0.59–11.97, p = 0.21), respectively. In the matched cohort, lower rate of toxicity was confirmed for patients undergoing SSRT, with acute GI and GU adverse events reported in 4.4 versus 44.4% ( p < 0.001) and 28.9 versus 46.7% ( p = 0.08) of patients, and late GI and GU adverse events reported in 0 versus 13.3% ( p = 0.04) and 6.7 versus 22.2% ( p = 0.03) of patients, respectively. Conclusion Considering the favourable therapeutic ratio of this approach and the lower number of fractions needed, SSRT should be considered as an attractive alternative to conventional SRT in this setting. Supplementary Information The online version contains supplementary material available at 10.1007/s11547-022-01465-w.

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Section: Discussionmentioning

confidence: 99%

Stereotactic or conventional radiotherapy for macroscopic prostate bed recurrence: a propensity score analysis

et al. 2022

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“…One of the major aims of the Italian Association of Radiation Oncology (AIRO)-Young Members Working Group (AIRO Giovani) is the conduction of studies and activities investigating different issues related to young members of the society. [7][8][9][10][11][12][13] The Pocketable Electronic Devices in Radiation Oncology (PEDRO) project is an international, web-based survey investigating the impact of MEDs on the clinical practice of young radiation oncologists. As a first step, we previously reported on exclusive Italian data.…”

Section: Introductionmentioning

confidence: 99%

The Pocketable Electronic Devices in Radiation Oncology (PEDRO) Project

Bari

Franco

Niyazi³

et al. 2015

Technol Cancer Res Treat

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Purpose: To analyze the impact of mobile electronic devices (MEDs) and apps in the daily clinical activity of young radiation or clinical oncologists in 5 Western European countries (Italy, Germany, Spain, Portugal, and Denmark). Methods: A web-based questionnaire was sent to 462 young (40 years) members of the national radiation or clinical oncology associations of the countries involved in the study. The 15 items investigated diffusion of MEDs (smartphones and/or tablets), their impact on daily clinical activity, and the differences perceived by participants along time. Results: A total of 386 (83.5%) of the 462 correctly filled questionnaires were statistically evaluated. Up to 65% of respondents declared to use an electronic device during their clinical activity. Conversely, 72% considered low to moderate impact of smartphones/tables on their daily practice. The daily use significantly increased from 2009 to 2012: users reporting a use 6 times/d raised from 5% to 39.9%. Professional needs fulfillment was declared by less than 68% of respondents and compliance to apps indications by 66%. Significant differences were seen among the countries, in particular concerning the feeling of usefulness of MEDs in the daily clinical life. This survey showed a large diffusion of MEDs in young professionals working in radiation oncology. Looking at these data, it is important to verify the consistency of information found within apps, in order to avoid potential errors eventually detrimental for patients. ''Quality assurance'' criteria should be specifically developed for medical apps and a comprehensive Web site gathering all reliable applications and tools might be useful for daily clinical practice.

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“…Radiotherapy as a salvage procedure is the treatment of choice and in such cases is usually performed on standardized volumes [7] corresponding to the PF. Presently, high doses (i.e., ≥70 Gy) are recommended and should be delivered to this whole clinical target volume [8]. However, the sophisticated RT techniques presently available, typically intensity modulated radiation therapy (IMRT), could allow such high doses to be delivered as a boost to the relapsing tumour mass, if detectable, and a lower dose (e.g., 60–64 Gy) to the “elective” volume, that is, the PF.…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Magnetic Resonance Diagnosis of Local Recurrences of Prostate Cancer after Radical Prostatectomy: Preliminary Evaluation on Twenty-Seven Cases

Carbone

Pirtoli

Ricci

et al. 2014

BioMed Research International

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Objectives. To assess the diagnostic performance of diffusion-weighted MR imaging (DWI) in patients affected by prostatic fossa (PF) relapse after radical prostatectomy (RP) for prostatic carcinoma (PC). Methods. Twenty-seven patients showing a nodular lesion in the PF at T2-weighted MR imaging after RP, with diagnosis of PC relapse established by biopsy or PSA determinations, were investigated by DWI. Two readers evaluated the DWI results in consensus and the apparent diffusion coefficient (ADC) of the nodules, separately; a mean value was obtained (ADCm). Results. Relapses did not significantly differ in size in respect of postsurgical benign nodules. The DWI qualitative evaluation showed sensitivity, specificity, accuracy, ppv, and npv values, respectively, of 83.3%, 88.9%, 85.2%, 93.7%, and 72.7% (100%, 87.5%, 95.6%, 93.7%, and 100%, for nodules >6 mm). The intraclass correlation coefficient (ICC) for ADC evaluation between the two readers was 0.852 (95% CI 0.661–0.935; P = 0.0001). The ADCm values for relapses and benign nodules were, respectively, 0.98 ± 0.21 × 10−3 mm2/sec and 1.24 ± 0.32 × 10−3 mm2/sec (P = 0.006). Sensitivity, specificity, accuracy, ppv and npv of ADCm were, respectively, 77.8%, 88.9%, 81.8%, 93.3%, and 66.7% (93.3%, 87.5%, 85.4%, 93.3%, and 87.5% for nodules >6 mm). Conclusions. Diffusion-weighted MR imaging is a promising tool in the management of a hyperintense nodule detected by T2-weighted sequences. This might have a relevant importance in contouring radiotherapy treatment volumes.

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The PROCAINA (PROstate CAncer INdication Attitudes) Project (Part I): a survey among Italian radiation oncologists on postoperative radiotherapy in prostate cancer

Cited by 20 publications

References 42 publications

Stereotactic or conventional radiotherapy for macroscopic prostate bed recurrence: a propensity score analysis

Stereotactic or conventional radiotherapy for macroscopic prostate bed recurrence: a propensity score analysis

The Pocketable Electronic Devices in Radiation Oncology (PEDRO) Project

Diffusion-Weighted Magnetic Resonance Diagnosis of Local Recurrences of Prostate Cancer after Radical Prostatectomy: Preliminary Evaluation on Twenty-Seven Cases

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