The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Abstract

In pharmaceutical nanotechnology, the intentional manipulation of working processes to fabricate nanoproducts with suitable properties for achieving the desired functional performances is highly sought after. The following paper aims to detail how a modified coaxial electrospraying has been developed to create ibuprofen-loaded hydroxypropyl methylcellulose nanoparticles for improving the drug dissolution rate. During the working processes, a key parameter, i.e., the spreading angle of atomization region (θ, °), could provide a linkage among the working process, the property of generated nanoparticles and their functional performance. Compared with the applied voltage (V, kV; D = 2713 − 82V with RθV2 = 0.9623), θ could provide a better correlation with the diameter of resultant nanoparticles (D, nm; D = 1096 − 5θ with RDθ2 = 0.9905), suggesting a usefulness of accurately predicting the nanoparticle diameter. The drug released from the electrosprayed nanoparticles involved both erosion and diffusion mechanisms. A univariate quadratic equation between the time of releasing 95% of the loaded drug (t, min) and D (t = 38.7 + 0.097D − 4.838 × 105D2 with a R2 value of 0.9976) suggests that the nanoparticle diameter has a profound influence on the drug release performance. The clear process-property-performance relationship should be useful for optimizing the electrospraying process, and in turn for achieving the desired medicated nanoparticles.

Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies

“…The electrospinning parameters (ratio blends of the polymer, applied voltage, injection rate and, the needle-to-collector (Table 1). We present the best activation function equations in the structure of the MLP model using eqn (14) and (15).…”

“…These parameters have a positive impact on downsizing of the nanobers. [14][15][16][17][18] Despite important experimental investigations to determine ber diameter, using scanning electron microscopy, transmission electron microscopy, and atomic force microscopy for example, it is still time-consuming and expensive. 18,19 Furthermore, complexities in the electrospinning method and many factors simultaneously affecting the preparation techniques cause the ndings from statistical tools, such as response surface methodology and regression analysis, to be very noisy.…”

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

“…Different arrays have been used by electrospraying for the formation of nanoparticles as coaxial electrospraying for core‐shell nanoparticles (Wang, Wen, Yu, Yang, & Zhang, ; Yang, Zhang, Wang, & Yu, ; Yu et al., ), coaxial electrospraying to creating high‐quality monolithic particles (Li et al., ; Liu et al., ; Yang, Zhang, Liu, Wang, & Yu, ), and to study the influences of experimental parameters and process characteristics on working processes (Huang et al., ). However, few publications can be found to investigate the relationships between the working fluids’ properties and their adaptability for electrospraying, which is a significant merit of the present work.…”

The Applications of Advanced Technologies in Dispelling Students Doubts’ about Their Majors

“…The knowledge of electrospraying can be extended to other types of material treatment knowledge. Particularly, the usage of electrosprayed nanoparticles can be found in all the applied fields [25][26][27]. The grasp of knowledge about electrospraying and the related practice experiences can help the college students to find suitable jobs for exerting both their knowledge and their capability.…”