The production in the rabbit of hypersensitive reactions to lens, rabbit muscle and low ragweed extracts by the action of staphylococcus toxin

Burky, Earl L.

doi:10.1016/s0021-8707(34)90245-8

Cited by 71 publications

(12 citation statements)

References 5 publications

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“…Results of this study (Table VII) of this micoorganism with other altered states of mammalian tissue reactivity (18,19). It is also relevant to recent reports of in vitro (20) and in vivo (21) cross-reactions between streptococcal and staphylococcal antigens.…”

Section: Discussionsupporting

confidence: 60%

The Bacterial Induction of Homograft Sensitivity

Rapaport

Chase

1965

The Journal of Experimental Medicine

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Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. Other bacteria tested included Lancefield streptococcal groups B, C, D, E, G, H, L, and O, pneumococcus Types II, III, XIV and a rough strain, Corynebacterium xerosis, Bacillus subtilis, Escherichia coli, Aerobacter aerogenes, Salmonella typhimurium, Proteus vulgaris, Neisseria catarrhalis, Haemophilus influenzae, and two human virulent strains of Mycobacterium tuberculosis. None of these microorganisms was active in the induction of homograft sensitivity in the guinea pig. Pretreatment of recipients with Gram-negative bacterial suspensions was associated with a slight increase in the mean survival time of first-set skin homografts. Results of this study suggest the presence in staphylococci, as well as in Group A streptococci, of antigens related in their biologic effects to tissue transplantation antigens.

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Section: Discussionsupporting

confidence: 60%

The Bacterial Induction of Homograft Sensitivity

Rapaport

Chase

1965

The Journal of Experimental Medicine

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“…The effect of bacterial components on antibody response to antigenic stimulus has received less attention. Staphylotoxin has been reported to raise the level of antibody developed in response to weakly antigenic substances such as ragweed pollen and crystalline beef lens, when administered combined with, or several hours prior to these antigens (8,9). This synergistic action of staphylotoxin has been used to advantage by Hecht et al in producing specific antiskin antibodies in rabbits (10).…”

mentioning

confidence: 99%

Studies on the O Antigen of Salmonella Typhosa

Johnson

Gaines

Landy

1956

The Journal of Experimental Medicine

293

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Investigations of factors affecting the immunological state of the host constitute a voluminous literature, most of which has been reviewed in a comprehensive treatise by Perla and Marmorston (1). However, of the great array of substances investigated, only a few have proved to be of consequence in that they provided new and productive approaches to improvement in the antibody response of the host.The contributions of major importance in this respect are: (a) the observations of Ramon (2) and of Glenn}" et al. (3) on the augmentation of antibody response to antigens adsorbed on particulate carriers; (b) the studies of Freund (4--6) which established the enhancement and prolongation of antibody response to antigens administered in water-in-oil emulsions; and (c) the finding that certain bacterial vaccines, notably pertussis and typhoid, incorporated in combined prophylactics, exert a synergistic effect on the antigenieity of toxoids (7).Study of the factors responsible for the elevated antibody levels following combined immunization has been limited, and the mechanisms by which these vaccines augment antitoxin formation are unknown. The effect of bacterial components on antibody response to antigenic stimulus has received less attention. Staphylotoxin has been reported to raise the level of antibody developed in response to weakly antigenic substances such as ragweed pollen and crystalline beef lens, when administered combined with, or several hours prior to these antigens (8,9). This synergistic action of staphylotoxin has been used to advantage by Hecht et al. in producing specific antiskin antibodies in rabbits (10). In addition, the type A toxoid of Clostridium

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“…This observation may be pertinent to the association of staphylococci with other states of altered mamma lian tissue reactivity [7,4]. It may represent an additional instance of the in vitro [8] and in vivo [6] cross-reactions described between streptococcal and staphylococcal antigenic components.…”

Section: Discussionmentioning

confidence: 97%