The production of dry powder by the sonocrystallisation for inhalation drug delivery

Muhammad, Syed Anuar Faua ad Syed; Oubani, Hussein; Abbas, Ali; Chan, Hak‐Kim; Kwok, Philip Chi Lip; Dehghani, Fariba

doi:10.1016/j.powtec.2013.05.019

Cited by 11 publications

(5 citation statements)

References 41 publications

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“…The use of ultrasound increased the product recovery to some extent (see experiment B) due to an increase in nucleation. The notion that ultrasound enhances nucleation has been reported extensively in the literature, including for cases with tubular crystallizers and cases with pulmonary APIs. ,,,, …”

Section: Resultsmentioning

confidence: 99%

“…The notion that ultrasound enhances nucleation has been reported extensively in the literature, including for cases with tubular crystallizers and cases with pulmonary APIs. 7,11,41,56,57 A substantial number of amorphous particles was produced in experiment B, which had a short residence time. Furthermore, preliminary experiments (not shown here) demonstrated that amorphous particles were also produced in cases with a very high supersaturation (up to S = 9.0).…”

Section: Resultsmentioning

confidence: 99%

“…Particles with an intermediate aerodynamic diameter (i.e., between 1 and 5 μm) can deposit in the lower airways by sedimentation and are in the optimal range for pulmonary drug delivery. , The manufacture of API particles with such a narrow size range is challenging. Consequently, various manufacturing methods, such as solution crystallization, − spray drying from solution, spray freeze-drying, − and supercritical fluid technology, − have been investigated intensively (please see a recent review for a comprehensive overview). The advantages of crystallization include mild operating conditions, high product purity, and the inherent stability of a crystalline product.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Hadiwinoto

Kwok

Tong

et al. 2019

Ind. Eng. Chem. Res.

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The manufacture of dry powders for pulmonary drug delivery is complicated by stringent requirements for the aerodynamic size distribution and solid-state properties of the powder. Micronization is often needed after conventional batch crystallization to reduce the particle size, which lowers the process yield and may lead to particles with poor aerosolization behavior. A novel process combining continuous plug-flow crystallization and spray drying is presented to produce crystals with optimal properties for pulmonary drug delivery in a single step. Continuous flow enables fast nucleation with antisolvent crystallization. Subsequently, the narrow and controllable residence time distribution of segmented-flow crystallization is exploited to grow the crystals uniformly into the optimal size range for pulmonary drug delivery. Finally, the solvent is evaporated rapidly using spray drying in a continuous flow. Two case studies involving relevant drugs for pulmonary delivery are presented to demonstrate practical relevance and process flexibility. The process can be optimized for both cases such that a dry powder with excellent aerosolization behavior is produced. The novel process is simple and flexible due to the clear separation of process functions and the availability of sufficient process variables for optimization.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Hadiwinoto

Kwok

Tong

et al. 2019

Ind. Eng. Chem. Res.

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show abstract

“…Byl použit ultrazvuk o frekvenci 24 Hz a isopropanol jako antisolvent. Za použití sprejové sušárny byly zformované částice vysušeny 26,27 . Příkladem léčivého přípravku používaného k léčbě astmatu a CHOPN je pomocí sonokrystalizace vyráběný Seretide ® (Glaxo-SmithKline, Irsko) s obsahem bronchodilatans salmeterolxinafoátu 28 .…”

Section: Metody Přípravy Suchých čáStic Pro Plicní Aplikaciunclassified

Dry Powder Particles for Pulmonary Application

Karas¹,

Vetchý²,

Gajdziok³

2022

Chem. Listy

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The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.

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“…In this case, additional mechanical milling is frequently required for further particle size reduction but the additional milling also brings problems such as surface property destruction and wide size distribution. For efficiently controlling the solid state property of API and overcoming the disadvantages in conventional route, novel crystallization processes such as supercritical fluid crystallization, sonocrystallization and nonphotochemical laser-induced nucleation technology have been designed and developed [4][5][6]. Sonocrystallization or ultrasonic crystallization, which is a process by incorporating power ultrasound in crystallization process, has been found to be a novel technique for controlling the different stages of crystallization and providing uniform mixing to reduce crystal agglomeration.…”

Section: Introductionmentioning

confidence: 99%

Recrystallization of phenacetin and sulfathiazole using the sonocrystallization process

Jheng

2016

Journal of the Taiwan Institute of Chemical Engineers

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The production of dry powder by the sonocrystallisation for inhalation drug delivery

Cited by 11 publications

References 41 publications

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation

Dry Powder Particles for Pulmonary Application

Recrystallization of phenacetin and sulfathiazole using the sonocrystallization process

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