The Production of Mutations in Drosophila by Tertiary -Butyl Hydroperoxide

Abstract

The mutagenic action of certain organic peroxides was first shown in work of Wyss, Stone, et al.1 in 1947-1948 on Micrococcus pyogenes (Staphylococcus aureus) and, soon afterward, in work of Dickey, Cleland, and Lotz2 in 1948 on Neurospora crassa. Because of the importance of peroxides in the production of mutations in microorganisms and as intermediates in the production of mutations by ultraviolet

Toxic and genetic effects of fuel oil photoproducts and three hydroperoxides inSaccharomyces cerevisiae

“…The only other hydroperoxide that has been reported to be mutagenic is tert-buty\. This compound is mutagenic in Drosophila (Altenburg, 1954) and in Neurospora (Dickey et al, 1949) and induces chromosome aberrations in Vicia faba (Loveless, 1951). Cumene hydroperoxide has been reported by Latarjet et al (1958) to be negative in a transformation test.…”

Evaluation of the potential of ozone as a power plant biocide

“…The specific ozone reaction products which produced the mutagenic effects in the above studies have not been identified. In nonaquatic organisms, however, organic peroxides and hydroperoxides have been shown to be capable o f inducing lethal mutations in Drosophila (Altenburg 1954, Sobels .1956), Neurospora (Dickey et al 1949), and Escherichia coli (Davis 1959). The LDS0 of linoleic acid peroxide (0.26 vrnol/g) was comparable to the level of organic peroxide previously found in mice after receiving an LD50 dose of X-rays (0.22 vmol/g) (Horgan et a1 .…”