The production of reactive oxygen species by dietary flavonols

Canada, Andrew T.; Giannella, E.; Nguyen, Toan D.; Mason, Ronald P.

doi:10.1016/0891-5849(90)90022-b

Cited by 128 publications

(81 citation statements)

References 17 publications

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“…It is interesting that CAT activity tended to be lower in the individuals fed locust leaves ( Figure 4), similar to chronic exposure of fourth larval instar to trophic stress by locust tree feeding (Perić-Mataruga et al, 1997). Considering that the phenol-induced stress results in increased formation of O 2 •− and consequently reactive oxygen species (Canada et al, 1990;Barbehenn and Martin, 1994;Barbehenn et al, 2001), regulation by SOD and CAT is necessary. SOD works continuously to eliminate O 2 •− with production of H 2 O 2 .…”

Section: Discussionmentioning

confidence: 97%

“…Here we showed a trend of higher mortality of L. dispar larvae given locust leaves for just 3 days. Ingested phenolic compounds become extensively oxidized, which produces ROS (Canada et al, 1990;Barbehenn et al, 2001;Barbehenn et al, 2009). Moreover, quinones, the oxidation products of phenols (Zheng et al, 1997;Barbehenn et al, 2006) may also be toxic and can cause the formation of gut lesions (Thiboldeaux et al, 1998;Perić-Mataruga et al, 2006a) and oxidative stress in the midgut tissues of L. dispar (Pecci, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Prothoracicotropic hormone-producing neurosecretory neurons and antioxidative defense in midgut of Lymantria dispar in trophic stress

Perić-Mataruga

Vlahović²,

Mrdaković³

2014

Turk J Biol

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IntroductionAs a gradogenic polyphagous and invasive species, the gypsy moth (Lymantria dispar L.) encounters different environmental challenges. Considering that its host range is estimated at more than 500 plant species within 73 families (Liebhold et al., 1995), the gypsy moth is characterized by a variety of adaptations that ensure survival and reproduction in heterogeneous and stressful environments. Problems with gypsy moth overcrowding are not solved yet (Demir et al., 2009(Demir et al., , 2012. Plants from the genus Quercus are accepted as the most suitable food and the most susceptible to L. dispar population eruptions (Maksimović, 1987;Liebhold et al., 1995). In the Republic of Serbia, large areas of forest and orchards were attacked (171,914 ha) by gypsy moths in 2012 according to the State Enterprise for Forest Management of Serbia (http:// www.srbijasume.rs/). Other parts of Europe are also at risk of gypsy moth invasion and degradation of forest ecosystems. This pest insect is one of the most serious insect defoliators of North American forests and urban landscapes according to the US Forest Service (http:// www.fs.fed.us/). Gypsy moth defoliation results in loss of growth, mortality of oak species, and shifts in species composition in mixed-oak forests (McGraw et al., 1990). Young oak leaves contain low amounts of flavonoids in spring when L. dispar attacks them (Salminen et al., 2004). A high population density of gypsy moths induces changes in leaf chemistry during defoliation, i.e. flavonoid content increases, leading to suppression of the insect immune response, and their resistance to viruses is lowered (Martemyanov et al., 2012). One of the very rare species of plant that is an unsuitable host for gypsy moths is the locust tree, Robinia pseudoacacia (Barbosa and Krischik, 1987). A nonfamiliar host plant for L. dispar, R. pseudoacacia is a widespread species in its native habitat in southeastern North America. It was introduced to Europe in 1601 (Chapman, 1935). Today, it has spread throughout western, central, eastern, and southern Europe and has become a major invasive species with a significant impact on native plant communities. Despite the large number of polyphagous species of Lepidoptera and the long period after the introduction of R. pseudoacacia to Europe, so far only a few native lepidopteran species have adapted to it (Kulfan, 2012). The unfavorable effects of locust leaves on gypsy moth larvae can be attributed to the presence of phenolic defensive compounds (Barbosa Abstract: As a very invasive insect species, Lymantria dispar is adaptable and sensitive to a changing environment. In insects the neuroendocrine system first reacts to stress by production of prothoracicotropic neurohormones (PTTH) that control ecdysteroid synthesis (morphogenetic and stress hormones). In this article, we report changes in the L2' brain neurosecretory neurons that synthesize PTTH in L. dispar larvae after feeding on locust tree leaves (Robinia pseudoacacia), an unsuitable host plant. Groups of larvae...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Prothoracicotropic hormone-producing neurosecretory neurons and antioxidative defense in midgut of Lymantria dispar in trophic stress

Perić-Mataruga

Vlahović²,

Mrdaković³

2014

Turk J Biol

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“…Luteolin and quercetin belong to the flavone and flavonol group, respectively, and both prevent H 2 O 2 -induced oxidative stress in oligodendroglia (van Meeteren et al, 2004). Some flavonoids, for example, quercetin, can redoxcycle (Hodnick et al, 1986) and have been shown to be pro-oxidants by the reduction of Fe 3 þ (Canada et al, 1990). This renders these compounds less suitable for therapeutical application (van Acker et al, 1996).…”

Section: Thiol-based Antioxidantsmentioning

confidence: 99%

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Meeteren¹,

Teunissen

Dijkstra

et al. 2005

Eur J Clin Nutr

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“…. In fact, quercetin can undergo auto-oxidation when dissolved in aqueous buffer generating free radicals as indicated by the generation of 5,5-dimethyl-1-pyrroline-Noxide-OH radicals detected by spin resonance spectroscopy (Canada et al, 1990). Likewise, quercetin generated O 2 .…”

Section: No Scavenging Effects Of Quercetin Under Nominally Anoxic Cmentioning

confidence: 99%

Nitric Oxide (NO) Scavenging and NO Protecting Effects of Quercetin and Their Biological Significance in Vascular Smooth Muscle

López-López

Moreno²,

Cogolludo³

et al. 2004

Mol Pharmacol

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The flavonoid quercetin reduces blood pressure and endothelial dysfunction in animal models of hypertension. However, the results concerning the relationship between quercetin and NO present a complex picture. We have analyzed the mechanisms involved in the NO scavenging effects of quercetin and its repercussion on NO bioactivity in vascular smooth muscle. Quercetin scavenged NO with apparent zero-order kinetics with respect to NO. This effect was strongly dependent on the O 2 concentrations, so that NO decay at pH 7.4 could be fitted to the equation

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The production of reactive oxygen species by dietary flavonols

Cited by 128 publications

References 17 publications

Prothoracicotropic hormone-producing neurosecretory neurons and antioxidative defense in midgut of Lymantria dispar in trophic stress

Prothoracicotropic hormone-producing neurosecretory neurons and antioxidative defense in midgut of Lymantria dispar in trophic stress

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Nitric Oxide (NO) Scavenging and NO Protecting Effects of Quercetin and Their Biological Significance in Vascular Smooth Muscle

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