The production of short chain fatty acid and colonic development in weaning piglets

Shi, Yang; Zhang, Jie; Zhang, Xianlian; Mo, Shilan; Tan, Xian-Zheng; Wang, Lixia; Li, Jianzhong; Li, Yali; Ding, Xueqin; Liu, Xianyong; Ma, Xiang; Yang, Huansheng; Yin, Yulong

doi:10.1111/jpn.13164

Cited by 21 publications

(11 citation statements)

References 30 publications

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“…Data were analyzed using the one-way ANOVA process in SPSS 25 statistical software (SPSS 20.0; SPSS Inc., Chicago, IL, USA) followed by Duncan’s multiple range tests, and the test results were expressed as the mean and standard error of the mean (SEM), where P < 0.05 was considered statistically significant, and 0.05 < P < 0.10 was considered to have a significant trend ( Zhou et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Zhang

Hou

et al. 2022

Front. Microbiol.

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Clostridium butyricum, as a probiotic with a variety of active products, has been widely used to improve the intestinal health of humans and animals. Previous studies had demonstrated that Clostridium butyricum exhibited potential protective and positive effects in human disease research and animal production by producing a variety of beneficial substances, such as intestinal inflammation, the intestinal epithelial barrier, metabolic diseases, and regulation of the gut microbiota. Therefore, we hypothesized that dietary Clostridium butyricum supplementation could improve gut health in fattening goats by modulating gut microbiota. However, it is unclear whether Clostridium butyricum can reach the intestine through the rumen, so 15 healthy Albas goats were selected and randomly divided into 3 treatments with 5 replicates in each group. The groups were divided as follows: control group (CON: basal diet), rumen-protected Clostridium butyricum group (RPCB: basal diet plus 1.0 × 109 CFU/kg Clostridium butyricum coated with hydrogenated fat), and Clostridium butyricum group (CB: basal diet plus 1.0 × 109 CFU/kg Clostridium butyricum). The experiment was slaughtered after a 70-day growth test, and the jejunal mucosa and intestinal contents of the goats were collected to determine tight junction proteins related genes expression and 16S rDNA microbial sequencing analysis to evaluate the intestine health. The results showed that dietary supplementation with Clostridium butyricum significantly increased the expression of the Claudin-4 gene of the jejunal mucosa (P < 0.05) and had a trend toward a significant increase in the Occludin gene (0.05 < P < 0.10). However, Clostridium butyricum had no significant effect on the expression of intestinal inflammatory factors (P > 0.10). In addition, the relative fractionation of Clostridium and Clostridiaceae_unclassified in the gut microbiota at the genus level decreased significantly compared with controls (P < 0.05). The results of the analysis of the level of Clostridium species showed that Clostridium butyricum only existed in the treatment group. And the correlation results showed that Occludin and Claudin-4 genes were positively correlated with Sharppea and Clostridium butyricum, and negatively correlated with Clostridium (P < 0.05). Supplementing Clostridium butyricum in the diet did not significantly affect the intestinal immune function of goats, while regulation of the intestinal microbiota was associated with improving the intestinal epithelial barrier.

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Section: Methodsmentioning

confidence: 99%

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Zhang

Hou

et al. 2022

Front. Microbiol.

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“…The SCFAs in the colon were analyzed according to a previous study ( Zhou et al, 2019 ). One gram of colon digesta was diluted with distilled water, then vortexed and centrifuged at 12,000 g for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

et al. 2021

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Recently, herbal extracts have been applied in multiple aspects, such as medicine and animal feed. Different compositions of herbal extract mixture (HEM) have various components and diverse functions. This study aimed to evaluate the effects of HEM (Lonicera japonica, Astragalus membranaceus, Eucommia folium, and Codonopsis pilosula) on intestinal antioxidant capacity and colonic microbiota in weaned pigs. A total of 18 piglets [Duroc × (Landrace × Yorkshire)] with the initial body weight of 5.99 ± 0.13 kg (weaned at 21 days) were randomly divided into two groups (n = 9): the control group (CON, basal diet) and the HEM treatment group (HEM, 1,000 mg/kg HEM + basal diet). The experiment period lasted for 14 days. Our results showed that dietary supplementation with HEM modulated the antioxidant capacity through decreasing the activity of superoxide dismutase (SOD) in the ileum and glutathione peroxidase (GSH-PX) in the serum, and decreasing the mRNA expression of Kelch like-ECH-associated protein 1 (Keap1) in the jejunum and the protein level of Keap1 in the ileum. Moreover, the HEM group modified the composition of colonic microbiota with affecting relative abundances of the Firmicutes and Bacteroidetes at the phylum level. Taken together, supplementation of HEM can regulate the antioxidant capacity and modify the composition of colonic bacteria in weaning piglets. This study provides new insights into the combination effects of herbal extracts on weaning piglets.

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“…Hence, reducing the backfat thickness of the Meishan pig breed by a convenient method, such as feeding probiotics, is an effective way to change this phenotype. Weaning at around 28 to 35 days old is a stressful event which impairs the function of the intestinal and immune systems and further results in the reduced production performance of piglets [ 46 , 47 ]. Furthermore, the nursing phase of piglets after weaning has a profound influence on the growth and development of pigs.…”

Section: Discussionmentioning

confidence: 99%

Exploring a Possible Link between the Fecal Microbiota and the Production Performance of Pigs

Cao

Wang

et al. 2022

Veterinary Sciences

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The backfat thickness of pigs not only affects the physical properties and taste of meat, but it also closely relates to the reproduction performance of sows. Accumulating evidence indicates that, apart from genetic factors, gut microbiota can also modulate the fat deposition and muscle growth. However, the differential microbiota in pigs with different backfat thickness, and whether microbiota affects backfat thickness, remains elusive. Firstly, 16S ribosomal RNA (16S rRNA) gene sequencing was performed on 62 fecal samples from pigs with different backfat thicknesses, and the compositions of microbiota among different groups with different backfat thicknesses were different. The abundance of Lactobacillus. reuteri (L. reuteri) and Prevotella sp RS2 was significantly higher in pigs with low-backfat thickness than that in pigs with middle and high-backfat thickness; meanwhile, the abundance of Desulfovibrio piger was significantly lower (p < 0.05) in pigs with low-backfat thickness. Furthermore, the functional profiling of microbial communities suggested that the abundance of isoquinoline alkaloid biosynthesis and styrene degradation were significantly lower (p < 0.05) in the low-backfat thickness group than that in middle and high-backfat thickness groups. Finally, L. reuteri fed to Meishan piglets was capable of improving the production performance and had the potential to reduce backfat thickness. This study provides new evidence that microbiota can regulate the phenotype of the host, and dietary supplementation with L. reuteri can improve the production performance of piglets.

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The production of short chain fatty acid and colonic development in weaning piglets

Cited by 21 publications

References 30 publications

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community

Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets

Exploring a Possible Link between the Fecal Microbiota and the Production Performance of Pigs

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